Abstract
Hepato protective properties of N-acetyl-L-cysteine (NAC) were investigated in rats under stress of radiation exposure in case of liver cirrhosis injury induced by carbon tetrachloride (CCl4) (tetrachloromethane). N-acetyl-L-cysteine treatment showed regression of cirrhosis in the liver tissue with significant inhibition of the increased liver malondialdehyde, triacylglycerols and cholesterol. Simultaneously, N-acetyl-L-cysteine suppressed the increase in plasma activities of aminotransferases (ALT, AST), alkaline phosphatase and billirubin, which are considered as markers of liver functional state. Status of oxidative/anti oxidative profile was the mechanistic approach to the nature of protection by N-acetyl-L-cysteine. Results revealed amelioration to a great extent in blood glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PDH) and catalase. Whole body exposure of rats to gamma-rays (four doses each of 4 Gy/dose/week) caused increases in lipid peroxides accompanied by depression of reduced glutathione (GSH). This decrease is probably due to the damages produced by the lipid peroxides. The activities of antioxidant enzymes; superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) were inhibited, which might be due to the increase of the superoxide radical and H2O2 and were accompanied also by a fall in glucose-6-phosphate dehydrogenase (G6PHD) activity. The excessive production of free radicals and lipid peroxides might cause
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Noaman, E;
Hedayat, I S;
Zakaria, S
[1]
- Radiation Biology Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)
Citation Formats
Noaman, E, Hedayat, I S, and Zakaria, S.
Hepatoprotective effect of N-acetyl -L-cysteine on C{sup l4} - induced liver damage in rats under oxidative stress of radiation exposure.
Egypt: N. p.,
2005.
Web.
Noaman, E, Hedayat, I S, & Zakaria, S.
Hepatoprotective effect of N-acetyl -L-cysteine on C{sup l4} - induced liver damage in rats under oxidative stress of radiation exposure.
Egypt.
Noaman, E, Hedayat, I S, and Zakaria, S.
2005.
"Hepatoprotective effect of N-acetyl -L-cysteine on C{sup l4} - induced liver damage in rats under oxidative stress of radiation exposure."
Egypt.
@misc{etde_20816846,
title = {Hepatoprotective effect of N-acetyl -L-cysteine on C{sup l4} - induced liver damage in rats under oxidative stress of radiation exposure}
author = {Noaman, E, Hedayat, I S, and Zakaria, S}
abstractNote = {Hepato protective properties of N-acetyl-L-cysteine (NAC) were investigated in rats under stress of radiation exposure in case of liver cirrhosis injury induced by carbon tetrachloride (CCl4) (tetrachloromethane). N-acetyl-L-cysteine treatment showed regression of cirrhosis in the liver tissue with significant inhibition of the increased liver malondialdehyde, triacylglycerols and cholesterol. Simultaneously, N-acetyl-L-cysteine suppressed the increase in plasma activities of aminotransferases (ALT, AST), alkaline phosphatase and billirubin, which are considered as markers of liver functional state. Status of oxidative/anti oxidative profile was the mechanistic approach to the nature of protection by N-acetyl-L-cysteine. Results revealed amelioration to a great extent in blood glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PDH) and catalase. Whole body exposure of rats to gamma-rays (four doses each of 4 Gy/dose/week) caused increases in lipid peroxides accompanied by depression of reduced glutathione (GSH). This decrease is probably due to the damages produced by the lipid peroxides. The activities of antioxidant enzymes; superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) were inhibited, which might be due to the increase of the superoxide radical and H2O2 and were accompanied also by a fall in glucose-6-phosphate dehydrogenase (G6PHD) activity. The excessive production of free radicals and lipid peroxides might cause leakage of cytosolic enzymes such as aminotransferases (AST and ALT) and alkaline phosphatase. Pretreatment with NAC (150 mg/kg) in saline for 7 days prevented the radiation-induced damage to an appreciable extent. From the results, it may be concluded that NAC is effective in protecting from the damages caused by gamma radiations in case of cirrhotic liver and its prospects as an adjuvant to radiotherapy should be considered. The anti fibrotic effect recorded in the experimental model of hepatic cirrhosis of rats suggests the use of N-acetyl-L-cysteine for hepato protection in the diet of patients with hepatopathies.}
journal = []
issue = {6}
volume = {37}
place = {Egypt}
year = {2005}
month = {Jul}
}
title = {Hepatoprotective effect of N-acetyl -L-cysteine on C{sup l4} - induced liver damage in rats under oxidative stress of radiation exposure}
author = {Noaman, E, Hedayat, I S, and Zakaria, S}
abstractNote = {Hepato protective properties of N-acetyl-L-cysteine (NAC) were investigated in rats under stress of radiation exposure in case of liver cirrhosis injury induced by carbon tetrachloride (CCl4) (tetrachloromethane). N-acetyl-L-cysteine treatment showed regression of cirrhosis in the liver tissue with significant inhibition of the increased liver malondialdehyde, triacylglycerols and cholesterol. Simultaneously, N-acetyl-L-cysteine suppressed the increase in plasma activities of aminotransferases (ALT, AST), alkaline phosphatase and billirubin, which are considered as markers of liver functional state. Status of oxidative/anti oxidative profile was the mechanistic approach to the nature of protection by N-acetyl-L-cysteine. Results revealed amelioration to a great extent in blood glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PDH) and catalase. Whole body exposure of rats to gamma-rays (four doses each of 4 Gy/dose/week) caused increases in lipid peroxides accompanied by depression of reduced glutathione (GSH). This decrease is probably due to the damages produced by the lipid peroxides. The activities of antioxidant enzymes; superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) were inhibited, which might be due to the increase of the superoxide radical and H2O2 and were accompanied also by a fall in glucose-6-phosphate dehydrogenase (G6PHD) activity. The excessive production of free radicals and lipid peroxides might cause leakage of cytosolic enzymes such as aminotransferases (AST and ALT) and alkaline phosphatase. Pretreatment with NAC (150 mg/kg) in saline for 7 days prevented the radiation-induced damage to an appreciable extent. From the results, it may be concluded that NAC is effective in protecting from the damages caused by gamma radiations in case of cirrhotic liver and its prospects as an adjuvant to radiotherapy should be considered. The anti fibrotic effect recorded in the experimental model of hepatic cirrhosis of rats suggests the use of N-acetyl-L-cysteine for hepato protection in the diet of patients with hepatopathies.}
journal = []
issue = {6}
volume = {37}
place = {Egypt}
year = {2005}
month = {Jul}
}