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Studies on cellular distribution of elements in human hepatocellular carcinoma samples by molecular activation analysis

Journal Article:

Abstract

The distribution patterns of 17 elements in the subcellular fractions of nuclei, mitochondria, lysosome, microsome and cytosol of human hepatocellular carcinoma (HCC) and normal liver samples were investigated by using molecular activation analysis (MAA) and differential centrifugation. Their significant difference was checked by the Studient's t-test. These elements exhibit inhomogeneous distributions in each subcellular fraction. Some elements have no significant difference between hepatocellular carcinoma and normal liver samples. However, the concentrations of Br, Ca, Cd and Cs are significantly higher in each component of hepatocarcinoma than in normal liver. The content of Fe in microsome of HCC is significantly lower, almost half of normal liver samples, but higher in other subcellular fractions than in those of normal tissues. The rare earth elements of La and Ce have the patterns similar to Fe. The concentrations of Sb and Zn in nuclei of HCC are obviously lower (P<0.05, P<0.05). The contents of K and Na are higher in cytosol of HCC (P<0.05). The distributions of Ba and Rb show no significant difference between two groups. The relationships of Fe, Cd and K with HCC were also discussed. The levels of some elements in subcellular fractions of tumor were quite different from those  More>>
Authors:
Guilong, Deng; [1]  Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)]; Chunying, Chen; Peiqun, Zhang; Jiujiang, Zhao; Zhifang, Chai; [1]  Yingbin, Liu; Jianwei, Wang; Bin, Xu; Shuyou, Peng [2] 
  1. Chinese Academy of Sciences, Beijing (China). Inst. of High Energy Physics, Key Laboratory of Nuclear Analytical Techniques
  2. Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)
Publication Date:
Jul 15, 2005
Product Type:
Journal Article
Resource Relation:
Journal Name: Nuclear Techniques; Journal Volume: 28; Journal Issue: 7; Other Information: 2 figs., 2 tabs., 23 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ACTIVATION ANALYSIS; CELL NUCLEI; DISTRIBUTION; ELEMENTS; HEPATOMAS; HUMAN POPULATIONS; LIVER; LYSOSOMES; MICROSOMES; MITOCHONDRIA; MOLECULES; RARE EARTHS; TRACE AMOUNTS
OSTI ID:
20809529
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 0253-3219; NUTEDL; TRN: CN0602876110904
Submitting Site:
INIS
Size:
page(s) 513-519
Announcement Date:
Dec 29, 2006

Journal Article:

Citation Formats

Guilong, Deng, Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)], Chunying, Chen, Peiqun, Zhang, Jiujiang, Zhao, Zhifang, Chai, Yingbin, Liu, Jianwei, Wang, Bin, Xu, and Shuyou, Peng. Studies on cellular distribution of elements in human hepatocellular carcinoma samples by molecular activation analysis. China: N. p., 2005. Web.
Guilong, Deng, Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)], Chunying, Chen, Peiqun, Zhang, Jiujiang, Zhao, Zhifang, Chai, Yingbin, Liu, Jianwei, Wang, Bin, Xu, & Shuyou, Peng. Studies on cellular distribution of elements in human hepatocellular carcinoma samples by molecular activation analysis. China.
Guilong, Deng, Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)], Chunying, Chen, Peiqun, Zhang, Jiujiang, Zhao, Zhifang, Chai, Yingbin, Liu, Jianwei, Wang, Bin, Xu, and Shuyou, Peng. 2005. "Studies on cellular distribution of elements in human hepatocellular carcinoma samples by molecular activation analysis." China.
@misc{etde_20809529,
title = {Studies on cellular distribution of elements in human hepatocellular carcinoma samples by molecular activation analysis}
author = {Guilong, Deng, Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang Univ., Hangzhou (China)], Chunying, Chen, Peiqun, Zhang, Jiujiang, Zhao, Zhifang, Chai, Yingbin, Liu, Jianwei, Wang, Bin, Xu, and Shuyou, Peng}
abstractNote = {The distribution patterns of 17 elements in the subcellular fractions of nuclei, mitochondria, lysosome, microsome and cytosol of human hepatocellular carcinoma (HCC) and normal liver samples were investigated by using molecular activation analysis (MAA) and differential centrifugation. Their significant difference was checked by the Studient's t-test. These elements exhibit inhomogeneous distributions in each subcellular fraction. Some elements have no significant difference between hepatocellular carcinoma and normal liver samples. However, the concentrations of Br, Ca, Cd and Cs are significantly higher in each component of hepatocarcinoma than in normal liver. The content of Fe in microsome of HCC is significantly lower, almost half of normal liver samples, but higher in other subcellular fractions than in those of normal tissues. The rare earth elements of La and Ce have the patterns similar to Fe. The concentrations of Sb and Zn in nuclei of HCC are obviously lower (P<0.05, P<0.05). The contents of K and Na are higher in cytosol of HCC (P<0.05). The distributions of Ba and Rb show no significant difference between two groups. The relationships of Fe, Cd and K with HCC were also discussed. The levels of some elements in subcellular fractions of tumor were quite different from those of normal liver, which suggested that trace elements might play important roles in the occurrence and development of hepatocellular carcinoma. (authors)}
journal = {Nuclear Techniques}
issue = {7}
volume = {28}
place = {China}
year = {2005}
month = {Jul}
}