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On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes

Abstract

Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study certain derivatives of imidazole and other compounds of similar structure. The results obtained showed: 1 - that the derivatives resulting from the presence in the imidazole ring of the mercapto, methyl, carbonyl, or benzyl groups are inactive: these substitutions appear to destroy the significant radioprotective activity of the imidazole, 2 - that benzimidazole, on the contrary, seems to possess highly interesting properties. The percentage of survivals obtained with mice treated with benzimidazole and exposed to lethal irradiation has encouraged the authors to undertake careful study of this substance, with a view to define optimum activity conditions, and to determine the mechanism responsible for its radioprotective action. Further on and so as to of clarify certain points that might give useful data concerning the mechanisms of action of radioprotective chemicals, in respect of each of the products the authors have studied: a - the action of these bodies on the internal temperature of mice, b - their radioprotective activity in vitro, in a solution of irradiated hemin. (authors) [French] Les proprietes radioprotectrices de l'imidazole ayant ete mises en evidence dans un precedent travail, les auteurs poursuivent  More>>
Authors:
Rinaldi, R; Bernard, Y [1] 
  1. Commissariat a l'Energie Atomique, Grenoble (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1964
Product Type:
Technical Report
Report Number:
CEA-R-2582
Resource Relation:
Other Information: 10 refs
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; BENZIMIDAZOLES; CHEMICAL PREPARATION; CHEMICAL PROPERTIES; HYPOTHERMIA; MICE; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES
OSTI ID:
20795940
Research Organizations:
CEA Grenoble, 38 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR06R2582097977
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
16 pages
Announcement Date:
Dec 19, 2006

Citation Formats

Rinaldi, R, and Bernard, Y. On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes. France: N. p., 1964. Web.
Rinaldi, R, & Bernard, Y. On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes. France.
Rinaldi, R, and Bernard, Y. 1964. "On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes." France.
@misc{etde_20795940,
title = {On the radioprotective properties of heterocyclic nitrogenous compounds; Etude des proprietes radioprotectrices de composes heterocycliques azotes}
author = {Rinaldi, R, and Bernard, Y}
abstractNote = {Continuing their study of the possible radioprotective properties of heterocyclic nitrogenous compounds, the authors study certain derivatives of imidazole and other compounds of similar structure. The results obtained showed: 1 - that the derivatives resulting from the presence in the imidazole ring of the mercapto, methyl, carbonyl, or benzyl groups are inactive: these substitutions appear to destroy the significant radioprotective activity of the imidazole, 2 - that benzimidazole, on the contrary, seems to possess highly interesting properties. The percentage of survivals obtained with mice treated with benzimidazole and exposed to lethal irradiation has encouraged the authors to undertake careful study of this substance, with a view to define optimum activity conditions, and to determine the mechanism responsible for its radioprotective action. Further on and so as to of clarify certain points that might give useful data concerning the mechanisms of action of radioprotective chemicals, in respect of each of the products the authors have studied: a - the action of these bodies on the internal temperature of mice, b - their radioprotective activity in vitro, in a solution of irradiated hemin. (authors) [French] Les proprietes radioprotectrices de l'imidazole ayant ete mises en evidence dans un precedent travail, les auteurs poursuivent leur experimentation sur certains derives de ce noyau ainsi que des composes de structure voisine. Leurs resultats montrent: 1 - que les composes obtenus par substitution d'un groupement mercapto, methyle, carbonyle ou benzyle, a un hydrogene du noyau imidazole sont inactifs, 2 - que le benzimidazole presente par contre des proprietes interessantes. Pour ce dernier compose le pourcentage de survie pouvant atteindre 90 pour cent les auteurs ont determine les conditions optimales de son activite radioprotectrice; de plus, dans le but d'obtenir des renseignements susceptibles de preciser le mecanisme d'action de la radioprotection, ils ont etudie pour chacun des produits experimentes d'une part leur action sur la temperature interne de la souris et d'autre part leur activite radioprotectrice in vitro vis-a-vis d'une solution d'hemine. (auteurs)}
place = {France}
year = {1964}
month = {Jul}
}