You need JavaScript to view this
ETDEWEB   /       /    Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage

Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage

Conference:

SAVE / SHARE

XML RIS EndNote CSV/Excel JSON

Abstract

Irradiation (IR) delivered to the head and neck is a common treatment for malignancies. Salivary glands in the irradiation field are severely damaged, and consequently this resulted in marked salivary hypofunction. While the exact mechanism of salivary gland damage remains enigmatic, fluid secreting acinar cells are lost, and saliva output is dramatically reduced. Previously we have reported that inducible heat shock protein 70 (HSP70i) induced radioresistance in vitro. Moreover, HSP70i localized to salivary glands by gene transfer has great potential for the treatment of salivary gland. Herein, we investigated whether HSP70 can use as radio protective molecules for radiation-induced salivary gland damage in vivo.
Authors:
Lee, Hae-June; Lee, Yoon-Jin; Kwon, Hee-Choong; Lee, Su-Jae; Bae, Sang-Woo; Lee, Yun-Sil; [1]  Kim, Sung-Ho [2] 
  1. Korea Institute of Radiological Medical Sciences, Seoul (Korea, Republic of)
  2. Chonnam National University, Gwangju (Korea, Republic of)
Publication Date:
Jul 01, 2006
Product Type:
Conference
Resource Relation:
Conference: 2006 spring meeting of the KNS, Gapyoung (Korea, Republic of), 25-26 May 2006; Other Information: 5 refs, 1 fig, 1 tab; Related Information: In: Proceedings of the KNS spring meeting, 1 CD-ROM pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GENES; HEAT-SHOCK PROTEINS; IN VITRO; IN VIVO; RADIOSENSITIVITY; SALIVARY GLANDS
OSTI ID:
20794671
Research Organizations:
Korean Nuclear Society, Taejon (Korea, Republic of)
Country of Origin:
Korea, Republic of
Language:
English
Other Identifying Numbers:
TRN: KR0602554096697
Availability:
Available from KNS, Taejon (KR)
Submitting Site:
KRN
Size:
2 pages
Announcement Date:
Dec 22, 2006

Conference:

SAVE / SHARE

XML RIS EndNote CSV/Excel JSON

Citation Formats

Lee, Hae-June, Lee, Yoon-Jin, Kwon, Hee-Choong, Lee, Su-Jae, Bae, Sang-Woo, Lee, Yun-Sil, and Kim, Sung-Ho. Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage. Korea, Republic of: N. p., 2006. Web.
Lee, Hae-June, Lee, Yoon-Jin, Kwon, Hee-Choong, Lee, Su-Jae, Bae, Sang-Woo, Lee, Yun-Sil, & Kim, Sung-Ho. Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage. Korea, Republic of.
Lee, Hae-June, Lee, Yoon-Jin, Kwon, Hee-Choong, Lee, Su-Jae, Bae, Sang-Woo, Lee, Yun-Sil, and Kim, Sung-Ho. 2006. "Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage." Korea, Republic of.
@misc{etde_20794671,
title = {Inducible HSP70 Protects Radiation-Induced Salivary Gland Damage}
 author = {Lee, Hae-June, Lee, Yoon-Jin, Kwon, Hee-Choong, Lee, Su-Jae, Bae, Sang-Woo, Lee, Yun-Sil, and Kim, Sung-Ho}
 abstractNote = {Irradiation (IR) delivered to the head and neck is a common treatment for malignancies. Salivary glands in the irradiation field are severely damaged, and consequently this resulted in marked salivary hypofunction. While the exact mechanism of salivary gland damage remains enigmatic, fluid secreting acinar cells are lost, and saliva output is dramatically reduced. Previously we have reported that inducible heat shock protein 70 (HSP70i) induced radioresistance in vitro. Moreover, HSP70i localized to salivary glands by gene transfer has great potential for the treatment of salivary gland. Herein, we investigated whether HSP70 can use as radio protective molecules for radiation-induced salivary gland damage in vivo.}
 place = {Korea, Republic of}
 year = {2006}
 month = {Jul}
 }