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Adaptive radiotherapy for invasive bladder cancer: A feasibility study

Abstract

Purpose: To evaluate the feasibility of adaptive radiotherapy (ART) in combination with a partial bladder irradiation. Methods and Materials: Twenty-one patients with solitary T1-T4 N0M0 bladder cancer were treated to the bladder tumor + 2 cm margin planning target volume (PTV{sub CONV}). During the first treatment week, five daily computed tomography (CT) scans were made immediately before or after treatment. In the second week, a volume was constructed encompassing the gross tumor volumes (GTVs) on the planning scan and the five CT scans (GTV{sub ART}). The GTV{sub ART} was expanded with a 1 cm margin for the construction of a PTV{sub ART}. Starting in the third week, patients were treated to PTV{sub ART}. Repeat CT scans were used to evaluate treatment accuracy. Results: On 5 of 91 repeat CT scans (5%), the GTV was not adequately covered by the PTV{sub ART}. On treatment planning, there was only one scan in which the GTV was not adequately covered by the 95% isodose. On average, the treatment volumes were reduced by 40% when comparing PTV{sub ART} with PTV{sub CONV} (p < 0.0001). Conclusion: The adaptive strategy for bladder cancer is an effective way to deal with treatment errors caused by variations in  More>>
Authors:
Pos, Floris J; [1]  Hulshof, Maarten; [2]  Lebesque, Joos; [1]  Lotz, Heidi; [1]  Tienhoven, Geertjan van; [2]  Moonen, Luc; [1]  Remeijer, Peter [1] 
  1. Department of Radiation Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)
  2. Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)
Publication Date:
Mar 01, 2006
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.07.976; PII: S0360-3016(05)02233-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; BLADDER; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; ERRORS; FEASIBILITY STUDIES; IRRADIATION; PATIENTS; RADIOTHERAPY
OSTI ID:
20793357
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US06R0717094996
Submitting Site:
INIS
Size:
page(s) 862-868
Announcement Date:
Dec 22, 2006

Citation Formats

Pos, Floris J, Hulshof, Maarten, Lebesque, Joos, Lotz, Heidi, Tienhoven, Geertjan van, Moonen, Luc, and Remeijer, Peter. Adaptive radiotherapy for invasive bladder cancer: A feasibility study. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Pos, Floris J, Hulshof, Maarten, Lebesque, Joos, Lotz, Heidi, Tienhoven, Geertjan van, Moonen, Luc, & Remeijer, Peter. Adaptive radiotherapy for invasive bladder cancer: A feasibility study. United States. doi:10.1016/J.IJROBP.2005.0.
Pos, Floris J, Hulshof, Maarten, Lebesque, Joos, Lotz, Heidi, Tienhoven, Geertjan van, Moonen, Luc, and Remeijer, Peter. 2006. "Adaptive radiotherapy for invasive bladder cancer: A feasibility study." United States. doi:10.1016/J.IJROBP.2005.0. https://www.osti.gov/servlets/purl/10.1016/J.IJROBP.2005.0.
@misc{etde_20793357,
title = {Adaptive radiotherapy for invasive bladder cancer: A feasibility study}
author = {Pos, Floris J, Hulshof, Maarten, Lebesque, Joos, Lotz, Heidi, Tienhoven, Geertjan van, Moonen, Luc, and Remeijer, Peter}
abstractNote = {Purpose: To evaluate the feasibility of adaptive radiotherapy (ART) in combination with a partial bladder irradiation. Methods and Materials: Twenty-one patients with solitary T1-T4 N0M0 bladder cancer were treated to the bladder tumor + 2 cm margin planning target volume (PTV{sub CONV}). During the first treatment week, five daily computed tomography (CT) scans were made immediately before or after treatment. In the second week, a volume was constructed encompassing the gross tumor volumes (GTVs) on the planning scan and the five CT scans (GTV{sub ART}). The GTV{sub ART} was expanded with a 1 cm margin for the construction of a PTV{sub ART}. Starting in the third week, patients were treated to PTV{sub ART}. Repeat CT scans were used to evaluate treatment accuracy. Results: On 5 of 91 repeat CT scans (5%), the GTV was not adequately covered by the PTV{sub ART}. On treatment planning, there was only one scan in which the GTV was not adequately covered by the 95% isodose. On average, the treatment volumes were reduced by 40% when comparing PTV{sub ART} with PTV{sub CONV} (p < 0.0001). Conclusion: The adaptive strategy for bladder cancer is an effective way to deal with treatment errors caused by variations in bladder tumor position and leads to a substantial reduction in treatment volumes.}
doi = {10.1016/J.IJROBP.2005.0}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {3}
volume = {64}
place = {United States}
year = {2006}
month = {Mar}
}