Abstract
O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET) is a promising tracer for PET that has demonstrated convincing results especially in the diagnostics of brain tumors. In contrast to other radiolabeled amino acids, it can be produced with high efficiency and distributed in a satellite concept like the widely used 2-[{sup 18}F]fluoro-2-deoxy-D-glucose. Although FET is not incorporated into proteins, it shows high uptake in cerebral gliomas and in extracranial squamous cell carcinomas owing to increased transport. The tracer exhibits high in vivo stability, low uptake in inflammatory tissue and suitable uptake kinetics for clinical imaging, which indicates that it may become a new standard tracer for PET. In this article, the present knowledge on the uptake mechanisms and the clinical applications of FET are reviewed and the clinical perspectives are discussed.
Langen, Karl-Josef;
[1]
Hamacher, Kurt;
[2]
Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)];
Weckesser, Matthias;
[3]
Floeth, Frank;
[4]
Stoffels, Gabriele;
[5]
Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)];
Bauer, Dagmar;
[5]
Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)];
Coenen, Heinz H;
[2]
Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)];
Pauleit, Dirk;
[5]
Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)]
- Institute of Medicine, Research Center Juelich, D-52425 Juelich (Germany) and Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)
- Institute of Nuclear Chemistry, Research Center Juelich, D-52425 Juelich (Germany)
- Department of Nuclear Medicine, University of Muenster, D-48149 Muenster (Germany)
- Department of Neurosurgery, Heinrich-Heine-University, D-40225 Duesseldorf (Germany)
- Institute of Medicine, Research Center Juelich, D-52425 Juelich (Germany)
Citation Formats
Langen, Karl-Josef, Hamacher, Kurt, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Weckesser, Matthias, Floeth, Frank, Stoffels, Gabriele, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Bauer, Dagmar, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Coenen, Heinz H, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Pauleit, Dirk, and Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)].
O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications.
United Kingdom: N. p.,
2006.
Web.
doi:10.1016/J.NUCMEDBIO.2006.0.
Langen, Karl-Josef, Hamacher, Kurt, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Weckesser, Matthias, Floeth, Frank, Stoffels, Gabriele, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Bauer, Dagmar, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Coenen, Heinz H, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Pauleit, Dirk, & Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)].
O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications.
United Kingdom.
https://doi.org/10.1016/J.NUCMEDBIO.2006.0
Langen, Karl-Josef, Hamacher, Kurt, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Weckesser, Matthias, Floeth, Frank, Stoffels, Gabriele, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Bauer, Dagmar, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Coenen, Heinz H, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Pauleit, Dirk, and Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)].
2006.
"O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications."
United Kingdom.
https://doi.org/10.1016/J.NUCMEDBIO.2006.0.
@misc{etde_20785718,
title = {O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications}
author = {Langen, Karl-Josef, Hamacher, Kurt, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Weckesser, Matthias, Floeth, Frank, Stoffels, Gabriele, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Bauer, Dagmar, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Coenen, Heinz H, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Pauleit, Dirk, and Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)]}
abstractNote = {O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET) is a promising tracer for PET that has demonstrated convincing results especially in the diagnostics of brain tumors. In contrast to other radiolabeled amino acids, it can be produced with high efficiency and distributed in a satellite concept like the widely used 2-[{sup 18}F]fluoro-2-deoxy-D-glucose. Although FET is not incorporated into proteins, it shows high uptake in cerebral gliomas and in extracranial squamous cell carcinomas owing to increased transport. The tracer exhibits high in vivo stability, low uptake in inflammatory tissue and suitable uptake kinetics for clinical imaging, which indicates that it may become a new standard tracer for PET. In this article, the present knowledge on the uptake mechanisms and the clinical applications of FET are reviewed and the clinical perspectives are discussed.}
doi = {10.1016/J.NUCMEDBIO.2006.0}
journal = []
issue = {3}
volume = {33}
place = {United Kingdom}
year = {2006}
month = {Apr}
}
title = {O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications}
author = {Langen, Karl-Josef, Hamacher, Kurt, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Weckesser, Matthias, Floeth, Frank, Stoffels, Gabriele, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Bauer, Dagmar, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Coenen, Heinz H, Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)], Pauleit, Dirk, and Brain Imaging Center West, Research Center Juelich, D-52425 Juelich (Germany)]}
abstractNote = {O-(2-[{sup 18}F]fluoroethyl)-L-tyrosine (FET) is a promising tracer for PET that has demonstrated convincing results especially in the diagnostics of brain tumors. In contrast to other radiolabeled amino acids, it can be produced with high efficiency and distributed in a satellite concept like the widely used 2-[{sup 18}F]fluoro-2-deoxy-D-glucose. Although FET is not incorporated into proteins, it shows high uptake in cerebral gliomas and in extracranial squamous cell carcinomas owing to increased transport. The tracer exhibits high in vivo stability, low uptake in inflammatory tissue and suitable uptake kinetics for clinical imaging, which indicates that it may become a new standard tracer for PET. In this article, the present knowledge on the uptake mechanisms and the clinical applications of FET are reviewed and the clinical perspectives are discussed.}
doi = {10.1016/J.NUCMEDBIO.2006.0}
journal = []
issue = {3}
volume = {33}
place = {United Kingdom}
year = {2006}
month = {Apr}
}