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Anandamide inhibits adhesion and migration of breast cancer cells

Abstract

The endocannabinoid system regulates cell proliferation in human breast cancer cells. We reasoned that stimulation of cannabinoid CB{sub 1} receptors could induce a non-invasive phenotype in breast mtastatic cells. In a model of metastatic spreading in vivo, the metabolically stable anandamide analogue, 2-methyl-2'-F-anandamide (Met-F-AEA), significantly reduced the number and dimension of metastatic nodes, this effect being antagonized by the selective CB{sub 1} antagonist SR141716A. In MDA-MB-231 cells, a highly invasive human breast cancer cell line, and in TSA-E1 cells, a murine breast cancer cell line, Met-F-AEA inhibited adhesion and migration on type IV collagen in vitro without modifying integrin expression: both these effects were antagonized by SR141716A. In order to understand the molecular mechanism involved in these processes, we analyzed the phosphorylation of FAK and Src, two tyrosine kinases involved in migration and adhesion. In Met-F-AEA-treated cells, we observed a decreased tyrosine phosphorylation of both FAK and Src, this effect being attenuated by SR141716A. We propose that CB{sub 1} receptor agonists inhibit tumor cell invasion and metastasis by modulating FAK phosphorylation, and that CB{sub 1} receptor activation might represent a novel therapeutic strategy to slow down the growth of breast carcinoma and to inhibit its metastatic diffusion in vivo.
Authors:
Grimaldi, Claudia; [1]  Pisanti, Simona; [1]  Laezza, Chiara; [2]  Malfitano, Anna Maria; [1]  Santoro, Antonietta; [1]  Vitale, Mario; [3]  Caruso, Maria Gabriella; [4]  Notarnicola, Maria; [4]  Iacuzzo, Irma; [1]  Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)]; Portella, Giuseppe; [2]  Di Marzo, Vincenzo; [5]  Bifulco, Maurizio [6] 
  1. Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, Universita degli Studi di Salerno, Fisciano (Italy)
  2. Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)
  3. Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita di Napoli Federico II (Italy)
  4. Laboratorio di Biochimica, IRCCS 'S. de Bellis', Castellana Grotte (Bari) (Italy)
  5. Istituto di Chimica Biomolecolare, C.N.R., Pozzuoli (Namibia) (Italy)
  6. Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, Universita degli Studi di Salerno, Fisciano (Sa) (Italy)
Publication Date:
Feb 15, 2006
Product Type:
Journal Article
Resource Relation:
Journal Name: Experimental Cell Research; Journal Volume: 312; Journal Issue: 4; Other Information: DOI: 10.1016/j.yexcr.2005.10.024; PII: S0014-4827(05)00509-4; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
60 APPLIED LIFE SCIENCES; CARCINOMAS; CELL PROLIFERATION; COLLAGEN; IN VITRO; IN VIVO; MAMMARY GLANDS; METASTASES; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTRANSFERASES; RECEPTORS; TUMOR CELLS; TYROSINE
OSTI ID:
20775337
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0014-4827; ECREAL; TRN: US06R0526078908
Submitting Site:
INIS
Size:
page(s) 363-373
Announcement Date:
Oct 16, 2006

Citation Formats

Grimaldi, Claudia, Pisanti, Simona, Laezza, Chiara, Malfitano, Anna Maria, Santoro, Antonietta, Vitale, Mario, Caruso, Maria Gabriella, Notarnicola, Maria, Iacuzzo, Irma, Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)], Portella, Giuseppe, Di Marzo, Vincenzo, and Bifulco, Maurizio. Anandamide inhibits adhesion and migration of breast cancer cells. United States: N. p., 2006. Web. doi:10.1016/j.yexcr.2005.10.024.
Grimaldi, Claudia, Pisanti, Simona, Laezza, Chiara, Malfitano, Anna Maria, Santoro, Antonietta, Vitale, Mario, Caruso, Maria Gabriella, Notarnicola, Maria, Iacuzzo, Irma, Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)], Portella, Giuseppe, Di Marzo, Vincenzo, & Bifulco, Maurizio. Anandamide inhibits adhesion and migration of breast cancer cells. United States. https://doi.org/10.1016/j.yexcr.2005.10.024
Grimaldi, Claudia, Pisanti, Simona, Laezza, Chiara, Malfitano, Anna Maria, Santoro, Antonietta, Vitale, Mario, Caruso, Maria Gabriella, Notarnicola, Maria, Iacuzzo, Irma, Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)], Portella, Giuseppe, Di Marzo, Vincenzo, and Bifulco, Maurizio. 2006. "Anandamide inhibits adhesion and migration of breast cancer cells." United States. https://doi.org/10.1016/j.yexcr.2005.10.024.
@misc{etde_20775337,
title = {Anandamide inhibits adhesion and migration of breast cancer cells}
author = {Grimaldi, Claudia, Pisanti, Simona, Laezza, Chiara, Malfitano, Anna Maria, Santoro, Antonietta, Vitale, Mario, Caruso, Maria Gabriella, Notarnicola, Maria, Iacuzzo, Irma, Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II (Italy)], Portella, Giuseppe, Di Marzo, Vincenzo, and Bifulco, Maurizio}
abstractNote = {The endocannabinoid system regulates cell proliferation in human breast cancer cells. We reasoned that stimulation of cannabinoid CB{sub 1} receptors could induce a non-invasive phenotype in breast mtastatic cells. In a model of metastatic spreading in vivo, the metabolically stable anandamide analogue, 2-methyl-2'-F-anandamide (Met-F-AEA), significantly reduced the number and dimension of metastatic nodes, this effect being antagonized by the selective CB{sub 1} antagonist SR141716A. In MDA-MB-231 cells, a highly invasive human breast cancer cell line, and in TSA-E1 cells, a murine breast cancer cell line, Met-F-AEA inhibited adhesion and migration on type IV collagen in vitro without modifying integrin expression: both these effects were antagonized by SR141716A. In order to understand the molecular mechanism involved in these processes, we analyzed the phosphorylation of FAK and Src, two tyrosine kinases involved in migration and adhesion. In Met-F-AEA-treated cells, we observed a decreased tyrosine phosphorylation of both FAK and Src, this effect being attenuated by SR141716A. We propose that CB{sub 1} receptor agonists inhibit tumor cell invasion and metastasis by modulating FAK phosphorylation, and that CB{sub 1} receptor activation might represent a novel therapeutic strategy to slow down the growth of breast carcinoma and to inhibit its metastatic diffusion in vivo.}
doi = {10.1016/j.yexcr.2005.10.024}
journal = []
issue = {4}
volume = {312}
place = {United States}
year = {2006}
month = {Feb}
}