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The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962)

Abstract

The object of this study is to show that the application of radioactivation analysis to the determination of iodine in biological media makes it possible to measure iodine concentrations of the order of 0.0001 {mu}g. After a review of the chemical methods with a mention of the difficulties they present, the optimum conditions for the determination of iodine in biological liquids are given. Three methods are described: - the first consists of a chemical treatment which liberates the protein bound iodine in an inorganic form. After distillation this iodine is irradiated in a flux of thermal neutrons. The induced radioactivity is compared to that of a standard sample irradiated in the same conditions by {gamma} spectrometry. - the second method which is of more general application consists in irradiating the sample and then extracting the iodine; its induced radio-activity is then measured by {beta}-counting. - the third method measures the iodine directly in the thyroid tissue by anti-compton spectrometry. The sensitivity, the reproducibility and the accuracy are discussed. Some applications are described: determination of iodine in its various organic forms in serum, determination of iodine in urines, in food-stuffs, etc., in the thyroid tissue, etc. (author) [French] Le but de  More>>
Authors:
Comar, D [1] 
  1. Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires
Publication Date:
Jun 15, 1962
Product Type:
Thesis/Dissertation
Report Number:
CEA-R-2095
Resource Relation:
Other Information: TH: These pharmacie; 36 refs
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; ACCURACY; BETA SPECTROSCOPY; BIOLOGICAL MATERIALS; COMPARATIVE EVALUATIONS; GAMMA SPECTROSCOPY; IODINE; NEUTRON ACTIVATION ANALYSIS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVATION; SEPARATION PROCESSES; STANDARDS; TRACE AMOUNTS
OSTI ID:
20740218
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France); Faculte de Pharmacie de l'Universite de Paris, 75 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR06R2095050034
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
42 pages
Announcement Date:
Jun 16, 2006

Citation Formats

Comar, D. The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962). France: N. p., 1962. Web.
Comar, D. The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962). France.
Comar, D. 1962. "The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962)." France.
@misc{etde_20740218,
title = {The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962)}
author = {Comar, D}
abstractNote = {The object of this study is to show that the application of radioactivation analysis to the determination of iodine in biological media makes it possible to measure iodine concentrations of the order of 0.0001 {mu}g. After a review of the chemical methods with a mention of the difficulties they present, the optimum conditions for the determination of iodine in biological liquids are given. Three methods are described: - the first consists of a chemical treatment which liberates the protein bound iodine in an inorganic form. After distillation this iodine is irradiated in a flux of thermal neutrons. The induced radioactivity is compared to that of a standard sample irradiated in the same conditions by {gamma} spectrometry. - the second method which is of more general application consists in irradiating the sample and then extracting the iodine; its induced radio-activity is then measured by {beta}-counting. - the third method measures the iodine directly in the thyroid tissue by anti-compton spectrometry. The sensitivity, the reproducibility and the accuracy are discussed. Some applications are described: determination of iodine in its various organic forms in serum, determination of iodine in urines, in food-stuffs, etc., in the thyroid tissue, etc. (author) [French] Le but de cette etude est de montrer que l'analyse par radioactivation appliquee au dosage de l'iode dans les milieux biologiques permet de mesurer des taux d'iode de l'ordie de 0,0001 {mu}g. Apres avoir rappele le principe des methodes chimiques et montre les difficultes de leur mise en oeuvre, il est etabli les conditions optima pour realiser le dosage de l'iode dans les liquides biologiques. Trois methodes sont decrites; - la premiere consiste a pratiquer un traitement chimique liberant l'iode proteique sous forme minerale. Apres distillation cet iode est irradie dans un flux de neutrons thermiques. La radioactivite induite est mesuree comparativement a celle d'un etalon traite dans les memes conditions par spectrometrie {gamma}. - la deuxieme methode d'application plus generale consiste a irradier l'echantillon puis a extraire l'iode, enfin a mesurer sa radioactivite induite par comptage {beta}. - la troisieme methode constitue un essai de dosage direct dans le tissu thyroidien par spectrometrie anticompton. La sensibilite, la reproductibilite et la precision sont discutees, quelques applications sont decrites: dosage de l'iode sous ses differentes formes organiques dans le serum, dosage de l'iode dans les urines, dans les aliments, etc., dans le tissu thyroidien, etc. (auteur)}
place = {France}
year = {1962}
month = {Jun}
}