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Improvement of locoregional hyperthermia treatments of oesophageal cancer using treatment planning

Abstract

Full text: The thermal dose achieved in the clinic often remains too low due to the incidence of treatment limiting hot spots, which are difficult to avoid intuitively due to the large number of degrees of freedom (amplitudes and phases) of the heating device. To improve hyperthermia treatments of oesophagus carcinoma patients with the 70 MHz AMC-4 waveguide system we performed hyperthermia treatment planning (HTP) with high resolution temperature based optimization. With this optimization we obtain amplitude (A) and phase (p) settings for the antennas for optimal tumor heating (> 43 {sup o}C) while preventing hot spots in normal tissue (< 42 {sup o}C) and maintaining the spinal cord temperature below 40 {sup o}C to prevent neurotoxicity. With the mixed A/P settings the highest absolute {delta}T's were achieved, while the ratio was not much different from the other two configurations. This implies that with these settings the same tumor heating can be obtained with less applied power, resulting in more efficient heating. The fact that the combined numerical A/clinical P settings resulted in the highest absolute temperature rises in the oesophagus might be due to the difference in patient positioning between the planning and the actual treatment, since the location  More>>
Authors:
Kok, H P; Haaren Van, P M.A.; Kamer Van de, J B; Zum Voerde Sive Voerding, P.J.; Wiersma, J; Hulshof, M C.C.M; Geijsen, E D; Crezee, J [1] 
  1. Department of Radiation Oncology, Academic Medical Center, University of Amsterdam (Netherlands)
Publication Date:
Jul 01, 2005
Product Type:
Conference
Report Number:
INIS-AT-0066
Resource Relation:
Conference: 22. Annual meeting of the European Society for Hyperthermic Oncology (Esho 2005), Graz (Austria), 8-11 Jun 2005; Related Information: In: Esho 2005. 22{sup nd} annual meeting of the European society for hyperthermic oncology. Book of abstracts, by Rehak, P.H.; Tscheliessnigg, K.H. [Medical University of Graz, Department of Surgery, Graz (Austria)] (eds.), 128 pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMPUTERIZED TOMOGRAPHY; ESOPHAGUS; HYPERTHERMIA; NEOPLASMS; PLANNING; SPINAL CORD; TEMPERATURE DEPENDENCE; THERAPY
Sponsoring Organizations:
Dutch Cancer Society (Netherlands)
OSTI ID:
20738386
Research Organizations:
Medical University of Graz, Department of Surgery, Graz (Austria)
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
TRN: AT0600060048158
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 38-39
Announcement Date:
Jun 19, 2006

Citation Formats

Kok, H P, Haaren Van, P M.A., Kamer Van de, J B, Zum Voerde Sive Voerding, P.J., Wiersma, J, Hulshof, M C.C.M, Geijsen, E D, and Crezee, J. Improvement of locoregional hyperthermia treatments of oesophageal cancer using treatment planning. Austria: N. p., 2005. Web.
Kok, H P, Haaren Van, P M.A., Kamer Van de, J B, Zum Voerde Sive Voerding, P.J., Wiersma, J, Hulshof, M C.C.M, Geijsen, E D, & Crezee, J. Improvement of locoregional hyperthermia treatments of oesophageal cancer using treatment planning. Austria.
Kok, H P, Haaren Van, P M.A., Kamer Van de, J B, Zum Voerde Sive Voerding, P.J., Wiersma, J, Hulshof, M C.C.M, Geijsen, E D, and Crezee, J. 2005. "Improvement of locoregional hyperthermia treatments of oesophageal cancer using treatment planning." Austria.
@misc{etde_20738386,
title = {Improvement of locoregional hyperthermia treatments of oesophageal cancer using treatment planning}
author = {Kok, H P, Haaren Van, P M.A., Kamer Van de, J B, Zum Voerde Sive Voerding, P.J., Wiersma, J, Hulshof, M C.C.M, Geijsen, E D, and Crezee, J}
abstractNote = {Full text: The thermal dose achieved in the clinic often remains too low due to the incidence of treatment limiting hot spots, which are difficult to avoid intuitively due to the large number of degrees of freedom (amplitudes and phases) of the heating device. To improve hyperthermia treatments of oesophagus carcinoma patients with the 70 MHz AMC-4 waveguide system we performed hyperthermia treatment planning (HTP) with high resolution temperature based optimization. With this optimization we obtain amplitude (A) and phase (p) settings for the antennas for optimal tumor heating (> 43 {sup o}C) while preventing hot spots in normal tissue (< 42 {sup o}C) and maintaining the spinal cord temperature below 40 {sup o}C to prevent neurotoxicity. With the mixed A/P settings the highest absolute {delta}T's were achieved, while the ratio was not much different from the other two configurations. This implies that with these settings the same tumor heating can be obtained with less applied power, resulting in more efficient heating. The fact that the combined numerical A/clinical P settings resulted in the highest absolute temperature rises in the oesophagus might be due to the difference in patient positioning between the planning and the actual treatment, since the location of the SAR focus in the tumor is constructed mainly by phase steering. The temperature rise near the spinal cord depends mainly on the power of the top antenna. The correlation coefficient was R=0.37, which was considerably higher than the correlation with the powers or phases of the other antennas. The temperature rise in the oesophagus depends mainly on the power of the top and bottom antenna together. The correlation coefficient was only R=0.12 but this was still more than 2 times higher than the correlation with the power of the left and right antenna. The relation between the temperature rise due to a power pulse of 30 seconds and the achieved steady state temperature was more or less linear, implying a higher T{sub 90} and T{sub 50} when a higher {delta}T was measured at the beginning of the treatment. (author)}
place = {Austria}
year = {2005}
month = {Jul}
}