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Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif

Abstract

In connection with a compartment theory, a kinetic study of thyroid metabolism in man requires the determination of the specific iodine activity at all accessible levels (plasma, urines, faeces), during periods of over a month; The basic methods required for such a study are therefore the use of iodine-125 as a tracer, the exact determination of iodine-127 using activation analysis and the setting-up of a daily diet of constant iodine content. The results are presented for each particular case and the main parameters of thyroid metabolism are calculated. The discussion includes some special considerations concerning the pathological condition of the subject or a break in the thyroid equilibrium. It shows in particular that constant disagreement exists between the experimental curves for the specific iodine activity and the corresponding theoretical curves for a conventional thyroid process based on 3 compartments; these discrepancies concern both the inorganic iodine and the organic iodine eliminated with the faeces. (author) [French] Dans le cadre d'une theorie a compartiments, l'etude cinetique du metabolisme thyroidien chez l'homme necessite la determination de l'activite specifique de l'iode a tous les niveaux accessibles (plasma, urines, feces), pendant des periodes depassant un mois. Les methodes de base indispensables pour une telle  More>>
Authors:
Riviere, R; [1]  Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires]
  1. Institut National de la Sante et de la Recherche Medicale, 75 - Paris (France)
Publication Date:
Jul 01, 1965
Product Type:
Technical Report
Report Number:
CEA-R-2787
Resource Relation:
Other Information: 40 refs
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ACTIVATION ANALYSIS; FECES; IODINE 125; IODINE 127; METABOLISM; PLASMA; RADIOMETRIC ANALYSIS; RADIONUCLIDE KINETICS; THYROID; TIME DEPENDENCE; URINE
OSTI ID:
20706585
Research Organizations:
CEA Saclay, 91 - Gif-sur-Yvette (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR05R2787021790
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
50 pages
Announcement Date:
May 01, 2006

Citation Formats

Riviere, R, and Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires]. Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif. France: N. p., 1965. Web.
Riviere, R, & Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires]. Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif. France.
Riviere, R, and Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires]. 1965. "Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif." France.
@misc{etde_20706585,
title = {Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif}
author = {Riviere, R, and Commissariat a l'Energie Atomique, Saclay (France). Centre d'Etudes Nucleaires]}
abstractNote = {In connection with a compartment theory, a kinetic study of thyroid metabolism in man requires the determination of the specific iodine activity at all accessible levels (plasma, urines, faeces), during periods of over a month; The basic methods required for such a study are therefore the use of iodine-125 as a tracer, the exact determination of iodine-127 using activation analysis and the setting-up of a daily diet of constant iodine content. The results are presented for each particular case and the main parameters of thyroid metabolism are calculated. The discussion includes some special considerations concerning the pathological condition of the subject or a break in the thyroid equilibrium. It shows in particular that constant disagreement exists between the experimental curves for the specific iodine activity and the corresponding theoretical curves for a conventional thyroid process based on 3 compartments; these discrepancies concern both the inorganic iodine and the organic iodine eliminated with the faeces. (author) [French] Dans le cadre d'une theorie a compartiments, l'etude cinetique du metabolisme thyroidien chez l'homme necessite la determination de l'activite specifique de l'iode a tous les niveaux accessibles (plasma, urines, feces), pendant des periodes depassant un mois. Les methodes de base indispensables pour une telle etude sont donc l'utilisation de l'iode 125 comme traceur, le dosage precis de l'iode 127 grace a l'analyse par activation et l'etablissement d'une diete journaliere constante en iode. Les resultats sont presentes pour chaque cas et les principaux parametres du metabolisme thyroidien calcules. La discussion fait part de considerations particulieres liees a l'etat pathologique du sujet ou a une rupture de l'equilibre thyroidien. Elle met surtout en lumiere des desaccords constants entre les courbes experimentales d'activite specifique de l'iode et les courbes theoriques correspondantes conformes au schema thyroidien classique a 3 compartiments; ces discordances concernent d'une part l'iode mineral, d'autre par l'iode organique elimine dans les feces. (auteur)}
place = {France}
year = {1965}
month = {Jul}
}