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Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1x8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors ({>=}12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.
Authors:
Rades, Dirk; [1]  Stalpers, Lukas J.A.; [2]  Hulshof, Maarten C.C.M.; [2]  Zschenker, Oliver; [3]  Alberti, Winfried; [4]  Koning, Caro C.E. [2] 
  1. Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg (Germany) and Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands)
  2. Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands)
  3. Department of Radiation Oncology, Section Radiobiology, University Hospital Hamburg-Eppendorf, Hamburg (Germany)
  4. Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg (Germany)
Publication Date:
Apr 01, 2005
Product Type:
Journal Article
Resource Relation:
Journal Name: Radiotherapy and Oncology; Journal Volume: 75; Journal Issue: 1; Other Information: DOI: 10.1016/j.radonc.2004.12.013; PII: S0167-8140(04)00577-8; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IRRADIATION; METASTASES; PATIENTS; RADIOTHERAPY; SPINAL CORD; TOXICITY
OSTI ID:
20703587
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0167-8140; RAONDT; TRN: IE05R0359018779
Submitting Site:
INIS
Size:
page(s) 70-73
Announcement Date:
May 01, 2006

Citation Formats

Rades, Dirk, Stalpers, Lukas J.A., Hulshof, Maarten C.C.M., Zschenker, Oliver, Alberti, Winfried, and Koning, Caro C.E. Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression. Ireland: N. p., 2005. Web. doi:10.1016/j.radonc.2004.12.013.
Rades, Dirk, Stalpers, Lukas J.A., Hulshof, Maarten C.C.M., Zschenker, Oliver, Alberti, Winfried, & Koning, Caro C.E. Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression. Ireland. https://doi.org/10.1016/j.radonc.2004.12.013
Rades, Dirk, Stalpers, Lukas J.A., Hulshof, Maarten C.C.M., Zschenker, Oliver, Alberti, Winfried, and Koning, Caro C.E. 2005. "Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression." Ireland. https://doi.org/10.1016/j.radonc.2004.12.013.
@misc{etde_20703587,
title = {Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression}
author = {Rades, Dirk, Stalpers, Lukas J.A., Hulshof, Maarten C.C.M., Zschenker, Oliver, Alberti, Winfried, and Koning, Caro C.E.}
abstractNote = {Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1x8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors ({>=}12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.}
doi = {10.1016/j.radonc.2004.12.013}
journal = []
issue = {1}
volume = {75}
place = {Ireland}
year = {2005}
month = {Apr}
}