Abstract
The radiolysis products of chloramphenicol under {gamma}-radiation sterilization were investigated systematically in the present study. Eight main radiolysis products were identified and quantified by HPLC-MS and HPLC-DAD, including two compounds that have never been reported. The minor radiolysis products were quantified, which shows that they are at the concentration levels below the threshold for identification. Carbon-carbon rupture reaction and oxidation reaction were proposed as the main radiolysis reactions of chloramphenicol powder. The applicability of {gamma}-sterilization for chloramphenicol products was quantitatively evaluated with qualitative and quantitative data and the data were compared to the threshold requirements of international regulations for identification. It was concluded that toxicities of the radiolysis products of chloramphenicol produced by {gamma}-radiation sterilization can be neglected, the radiolysis products are safe for human health from chemical view. (author)
Hong, L;
Altorfer, H R;
[1]
Horni, A;
Hesse, M
[2]
- Institute of Pharmaceutical Science, Swiss Federal Institute of Technology (ETH), Zurich (Switzerland)
- Institute of Organic Chemistry, University of Zurich, Zurich (Switzerland)
Citation Formats
Hong, L, Altorfer, H R, Horni, A, and Hesse, M.
Identification and evaluation of radiolysis products of irradiated chloramphenicol by HPLC-MS and HPLC-DAD.
IAEA: N. p.,
2005.
Web.
Hong, L, Altorfer, H R, Horni, A, & Hesse, M.
Identification and evaluation of radiolysis products of irradiated chloramphenicol by HPLC-MS and HPLC-DAD.
IAEA.
Hong, L, Altorfer, H R, Horni, A, and Hesse, M.
2005.
"Identification and evaluation of radiolysis products of irradiated chloramphenicol by HPLC-MS and HPLC-DAD."
IAEA.
@misc{etde_20693057,
title = {Identification and evaluation of radiolysis products of irradiated chloramphenicol by HPLC-MS and HPLC-DAD}
author = {Hong, L, Altorfer, H R, Horni, A, and Hesse, M}
abstractNote = {The radiolysis products of chloramphenicol under {gamma}-radiation sterilization were investigated systematically in the present study. Eight main radiolysis products were identified and quantified by HPLC-MS and HPLC-DAD, including two compounds that have never been reported. The minor radiolysis products were quantified, which shows that they are at the concentration levels below the threshold for identification. Carbon-carbon rupture reaction and oxidation reaction were proposed as the main radiolysis reactions of chloramphenicol powder. The applicability of {gamma}-sterilization for chloramphenicol products was quantitatively evaluated with qualitative and quantitative data and the data were compared to the threshold requirements of international regulations for identification. It was concluded that toxicities of the radiolysis products of chloramphenicol produced by {gamma}-radiation sterilization can be neglected, the radiolysis products are safe for human health from chemical view. (author)}
place = {IAEA}
year = {2005}
month = {Jul}
}
title = {Identification and evaluation of radiolysis products of irradiated chloramphenicol by HPLC-MS and HPLC-DAD}
author = {Hong, L, Altorfer, H R, Horni, A, and Hesse, M}
abstractNote = {The radiolysis products of chloramphenicol under {gamma}-radiation sterilization were investigated systematically in the present study. Eight main radiolysis products were identified and quantified by HPLC-MS and HPLC-DAD, including two compounds that have never been reported. The minor radiolysis products were quantified, which shows that they are at the concentration levels below the threshold for identification. Carbon-carbon rupture reaction and oxidation reaction were proposed as the main radiolysis reactions of chloramphenicol powder. The applicability of {gamma}-sterilization for chloramphenicol products was quantitatively evaluated with qualitative and quantitative data and the data were compared to the threshold requirements of international regulations for identification. It was concluded that toxicities of the radiolysis products of chloramphenicol produced by {gamma}-radiation sterilization can be neglected, the radiolysis products are safe for human health from chemical view. (author)}
place = {IAEA}
year = {2005}
month = {Jul}
}