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Studies of radiation effects on allopathic formulations for cancer management

Abstract

In the present study, two anticancer drugs, Cyclophosphamide and Doxorubucin Hydrochloride have been investigated. The results of various physico-chemical tests on unirradiated and irradiated drugs indicate possibility of use of lower radiation doses and cryo-irradiation in case of sterilization of Cyclophosphamide. Doxorubcin Hydrochloride could be sterilized at 25 kGy without any significant changes in its physico-chemical properties. HPLC studies reveal formation of several trace level degradation products in irradiated cyclophosphamide. HPLC/MS studies revealed that higher and lower molecular weight products of the original molecules are formed on irradiation. Although, no significant changes are observed in absolute purity values, a little discolouration and formation of degradation products in Cyclophosphamide are the main impediments in acceptability of radiation sterilization. On the other hand, orange-red coloured Doxorubicin Hydrochloride did not show any such changes and could be radiation sterilized at normal sterilization dose of 25 kGy. (author)
Authors:
Varshney, L; Choughule, S V; Dodke, P B; Jothish, P K [1] 
  1. International Standard Orthopedic Measurements Education and Development (ISOMED), Bhabha Atomic Research Centre, Mumbai (India)
Publication Date:
Jul 01, 2005
Product Type:
Technical Report
Report Number:
INIS-XA-823
Resource Relation:
Other Information: 10 refs, 20 figs, 7 tabs; Related Information: In: Coordinated research project on radiation sterilization and decontamination of pharmaceuticals and pharmaceutical raw materials. CRP report, 126 pages.
Subject:
60 APPLIED LIFE SCIENCES; CHEMICAL PROPERTIES; DOXORUBICIN; ENDOXAN; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; MOLECULAR WEIGHT; NEOPLASMS; RADIATION DOSES; RADIATION EFFECTS; RADIOSTERILIZATION
OSTI ID:
20693054
Research Organizations:
International Atomic Energy Agency, Division of Physical and Chemical Sciences, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0502759009878
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 52-69
Announcement Date:
Mar 27, 2006

Citation Formats

Varshney, L, Choughule, S V, Dodke, P B, and Jothish, P K. Studies of radiation effects on allopathic formulations for cancer management. IAEA: N. p., 2005. Web.
Varshney, L, Choughule, S V, Dodke, P B, & Jothish, P K. Studies of radiation effects on allopathic formulations for cancer management. IAEA.
Varshney, L, Choughule, S V, Dodke, P B, and Jothish, P K. 2005. "Studies of radiation effects on allopathic formulations for cancer management." IAEA.
@misc{etde_20693054,
title = {Studies of radiation effects on allopathic formulations for cancer management}
author = {Varshney, L, Choughule, S V, Dodke, P B, and Jothish, P K}
abstractNote = {In the present study, two anticancer drugs, Cyclophosphamide and Doxorubucin Hydrochloride have been investigated. The results of various physico-chemical tests on unirradiated and irradiated drugs indicate possibility of use of lower radiation doses and cryo-irradiation in case of sterilization of Cyclophosphamide. Doxorubcin Hydrochloride could be sterilized at 25 kGy without any significant changes in its physico-chemical properties. HPLC studies reveal formation of several trace level degradation products in irradiated cyclophosphamide. HPLC/MS studies revealed that higher and lower molecular weight products of the original molecules are formed on irradiation. Although, no significant changes are observed in absolute purity values, a little discolouration and formation of degradation products in Cyclophosphamide are the main impediments in acceptability of radiation sterilization. On the other hand, orange-red coloured Doxorubicin Hydrochloride did not show any such changes and could be radiation sterilized at normal sterilization dose of 25 kGy. (author)}
place = {IAEA}
year = {2005}
month = {Jul}
}