Abstract
Yttrium-90, produced by irradiating Y{sub 2}O{sub 3} (15 mg) in the Pakistan Research Reactor (PARR-I) at a flux of {approx}1.5x10{sup 14} neutrons/cm{sup 2}/s, was used to prepare yttrium-90 hydroxyapatite particles for radiosynovectomy applications. The irradiated material was dissolved in concentrated hydrochloric acid, evaporated and taken up in distilled water. The 120 h irradiation resulted in the production of {approx}12 GBq (324 mCi) of {sup 90}Y at the end of irradiation (EOI) and the corresponding specific activity was {approx}1017 GBq/g of yttrium. Hydroxyapatite (HA) particles were synthesized by an already reported method. Labeling of HA particles with {sup 90}Y was studied without a transchelating agent. Labeling yields of {approx}100% could be achieved with 40 mg of HA and 0.4 mg of {sup 90}Y. In vitro studies showed <2% loss of {sup 90}Y activity in normal saline and 1% human serum albumin solution over a period of 8 days. The high labeling yield, good stability and ease of preparation of the {sup 90}Y-HA particles indicate that these particles may find wide application in radiation synovectomy.
Khalid, M;
[1]
Mushtaq, A
[1]
- Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad (Pakistan)
Citation Formats
Khalid, M, and Mushtaq, A.
Preparation and in vitro stability of (n,{gamma}) yttrium-90 hydroxyapatite.
United Kingdom: N. p.,
2005.
Web.
doi:10.1016/j.apradiso.2004.08.046.
Khalid, M, & Mushtaq, A.
Preparation and in vitro stability of (n,{gamma}) yttrium-90 hydroxyapatite.
United Kingdom.
https://doi.org/10.1016/j.apradiso.2004.08.046
Khalid, M, and Mushtaq, A.
2005.
"Preparation and in vitro stability of (n,{gamma}) yttrium-90 hydroxyapatite."
United Kingdom.
https://doi.org/10.1016/j.apradiso.2004.08.046.
@misc{etde_20620212,
title = {Preparation and in vitro stability of (n,{gamma}) yttrium-90 hydroxyapatite}
author = {Khalid, M, and Mushtaq, A}
abstractNote = {Yttrium-90, produced by irradiating Y{sub 2}O{sub 3} (15 mg) in the Pakistan Research Reactor (PARR-I) at a flux of {approx}1.5x10{sup 14} neutrons/cm{sup 2}/s, was used to prepare yttrium-90 hydroxyapatite particles for radiosynovectomy applications. The irradiated material was dissolved in concentrated hydrochloric acid, evaporated and taken up in distilled water. The 120 h irradiation resulted in the production of {approx}12 GBq (324 mCi) of {sup 90}Y at the end of irradiation (EOI) and the corresponding specific activity was {approx}1017 GBq/g of yttrium. Hydroxyapatite (HA) particles were synthesized by an already reported method. Labeling of HA particles with {sup 90}Y was studied without a transchelating agent. Labeling yields of {approx}100% could be achieved with 40 mg of HA and 0.4 mg of {sup 90}Y. In vitro studies showed <2% loss of {sup 90}Y activity in normal saline and 1% human serum albumin solution over a period of 8 days. The high labeling yield, good stability and ease of preparation of the {sup 90}Y-HA particles indicate that these particles may find wide application in radiation synovectomy.}
doi = {10.1016/j.apradiso.2004.08.046}
journal = []
issue = {4}
volume = {62}
journal type = {AC}
place = {United Kingdom}
year = {2005}
month = {Apr}
}
title = {Preparation and in vitro stability of (n,{gamma}) yttrium-90 hydroxyapatite}
author = {Khalid, M, and Mushtaq, A}
abstractNote = {Yttrium-90, produced by irradiating Y{sub 2}O{sub 3} (15 mg) in the Pakistan Research Reactor (PARR-I) at a flux of {approx}1.5x10{sup 14} neutrons/cm{sup 2}/s, was used to prepare yttrium-90 hydroxyapatite particles for radiosynovectomy applications. The irradiated material was dissolved in concentrated hydrochloric acid, evaporated and taken up in distilled water. The 120 h irradiation resulted in the production of {approx}12 GBq (324 mCi) of {sup 90}Y at the end of irradiation (EOI) and the corresponding specific activity was {approx}1017 GBq/g of yttrium. Hydroxyapatite (HA) particles were synthesized by an already reported method. Labeling of HA particles with {sup 90}Y was studied without a transchelating agent. Labeling yields of {approx}100% could be achieved with 40 mg of HA and 0.4 mg of {sup 90}Y. In vitro studies showed <2% loss of {sup 90}Y activity in normal saline and 1% human serum albumin solution over a period of 8 days. The high labeling yield, good stability and ease of preparation of the {sup 90}Y-HA particles indicate that these particles may find wide application in radiation synovectomy.}
doi = {10.1016/j.apradiso.2004.08.046}
journal = []
issue = {4}
volume = {62}
journal type = {AC}
place = {United Kingdom}
year = {2005}
month = {Apr}
}