Abstract
Seven new nitrophenol derivatives were synthesized; their {sup 99m}Tc complexes (N{sub 2}OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [{sup 99m}Tc]NaTcO{sub 4} in the presence of SnCl{sub 2} at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of {sup 99m}Tc with 3-[3'-N-(2''-hydroxy-5''-nitrobenzylamino)- 2'-hydroxypropyl]-1-methylthiourea.
Dzhalilian, A R;
Bineshmarvasti, M;
[1]
Kumar, P;
Vibe, L I
[2]
- Departament Tsiklotronnoj I Yadernoj Meditsiny Tsentra Yadernykh Issledovanij dlya Sel'skogo Khozyajstva I Meditsiny, Karadzh (Iran, Islamic Republic of)
- Fakul'tet Farmatsevtiki i Farmatsevticheskikh Nauk Universiteta Al'berty, Ehdmonton (Canada)
Citation Formats
Dzhalilian, A R, Bineshmarvasti, M, Kumar, P, and Vibe, L I.
Synthesis and stability of new nitrophenol complexes of {sup 99m}Tc as possible hypoxia imaging radiopharmaceuticals; Poluchenie i ustojchivost' novykh nitrofenol'nykh kompleksov {sup 99m}Ts - potentsial'nykh radiofarmpreparatov dlya vizualizatsii gipoksii.
Russian Federation: N. p.,
2005.
Web.
Dzhalilian, A R, Bineshmarvasti, M, Kumar, P, & Vibe, L I.
Synthesis and stability of new nitrophenol complexes of {sup 99m}Tc as possible hypoxia imaging radiopharmaceuticals; Poluchenie i ustojchivost' novykh nitrofenol'nykh kompleksov {sup 99m}Ts - potentsial'nykh radiofarmpreparatov dlya vizualizatsii gipoksii.
Russian Federation.
Dzhalilian, A R, Bineshmarvasti, M, Kumar, P, and Vibe, L I.
2005.
"Synthesis and stability of new nitrophenol complexes of {sup 99m}Tc as possible hypoxia imaging radiopharmaceuticals; Poluchenie i ustojchivost' novykh nitrofenol'nykh kompleksov {sup 99m}Ts - potentsial'nykh radiofarmpreparatov dlya vizualizatsii gipoksii."
Russian Federation.
@misc{etde_20617427,
title = {Synthesis and stability of new nitrophenol complexes of {sup 99m}Tc as possible hypoxia imaging radiopharmaceuticals; Poluchenie i ustojchivost' novykh nitrofenol'nykh kompleksov {sup 99m}Ts - potentsial'nykh radiofarmpreparatov dlya vizualizatsii gipoksii}
author = {Dzhalilian, A R, Bineshmarvasti, M, Kumar, P, and Vibe, L I}
abstractNote = {Seven new nitrophenol derivatives were synthesized; their {sup 99m}Tc complexes (N{sub 2}OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [{sup 99m}Tc]NaTcO{sub 4} in the presence of SnCl{sub 2} at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of {sup 99m}Tc with 3-[3'-N-(2''-hydroxy-5''-nitrobenzylamino)- 2'-hydroxypropyl]-1-methylthiourea.}
journal = []
issue = {2}
volume = {47}
journal type = {AC}
place = {Russian Federation}
year = {2005}
month = {Mar}
}
title = {Synthesis and stability of new nitrophenol complexes of {sup 99m}Tc as possible hypoxia imaging radiopharmaceuticals; Poluchenie i ustojchivost' novykh nitrofenol'nykh kompleksov {sup 99m}Ts - potentsial'nykh radiofarmpreparatov dlya vizualizatsii gipoksii}
author = {Dzhalilian, A R, Bineshmarvasti, M, Kumar, P, and Vibe, L I}
abstractNote = {Seven new nitrophenol derivatives were synthesized; their {sup 99m}Tc complexes (N{sub 2}OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [{sup 99m}Tc]NaTcO{sub 4} in the presence of SnCl{sub 2} at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of {sup 99m}Tc with 3-[3'-N-(2''-hydroxy-5''-nitrobenzylamino)- 2'-hydroxypropyl]-1-methylthiourea.}
journal = []
issue = {2}
volume = {47}
journal type = {AC}
place = {Russian Federation}
year = {2005}
month = {Mar}
}