Abstract
The aim of the study was the evaluation of the perfusion, morphology and biliary three patency of liver transplants employing two radionuclide methods. The study was performed on 10 controls and 10 patients after an orthotopic transplantation (up to two years). 'First pass' dynamic acquisition was performed with a scintillation camera, after a bolus injection of 360 MBq {sup 99m}Tc-diethyl-IDA, (60 frames/60 s), continued by a 59 minute (1 frame/min) slower dynamic study. From the liver and kidney activity during the 'first pass' study, the hepatic perfusion index (HPI) was calculated using slope-analysis. Hepatobiliary scintigrams obtained during second phase of the study were analyzed for morphology, and parenchymal and hepatobiliary TA curves were generated and analyzed according to the time to maximal activity (T{sub max}) and the time to half of maximum activity (T/2). In comparison to the controls (HPI, X = 0.64.5 {+-} 0.05%) portal perfusion had slightly (X = 0.68 {+-} 0.04%), but not significantly (p > 0.05) increased. In 3 patients, the biliary phase of hepatobiliary scintigraphy showed an increased accumulation of the radiopharmaceutical in the left (n = 1) or right (n = 2) hepatic duct. The uptake of the radiopharmaceutical (T{sub max}, X = 18.5
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Obradovic, V;
Artiko, V;
Petrovic, N;
[1]
Radevic, B;
[2]
Dapcevic, B
[3]
- Institute for Nuclear Medicine, Clinical Centre of Serbia, Belgrade (Serbia and Montenegro)
- Institute for Cardiovascular Diseases, 'Dedinje', Belgrade (Serbia and Montenegro)
- Department for Digestive Diseases, Clinical Centre 'Zvezdra', Belgrade (Serbia and Montenegro)
Citation Formats
Obradovic, V, Artiko, V, Petrovic, N, Radevic, B, and Dapcevic, B.
Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function.
Poland: N. p.,
2004.
Web.
Obradovic, V, Artiko, V, Petrovic, N, Radevic, B, & Dapcevic, B.
Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function.
Poland.
Obradovic, V, Artiko, V, Petrovic, N, Radevic, B, and Dapcevic, B.
2004.
"Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function."
Poland.
@misc{etde_20617215,
title = {Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function}
author = {Obradovic, V, Artiko, V, Petrovic, N, Radevic, B, and Dapcevic, B}
abstractNote = {The aim of the study was the evaluation of the perfusion, morphology and biliary three patency of liver transplants employing two radionuclide methods. The study was performed on 10 controls and 10 patients after an orthotopic transplantation (up to two years). 'First pass' dynamic acquisition was performed with a scintillation camera, after a bolus injection of 360 MBq {sup 99m}Tc-diethyl-IDA, (60 frames/60 s), continued by a 59 minute (1 frame/min) slower dynamic study. From the liver and kidney activity during the 'first pass' study, the hepatic perfusion index (HPI) was calculated using slope-analysis. Hepatobiliary scintigrams obtained during second phase of the study were analyzed for morphology, and parenchymal and hepatobiliary TA curves were generated and analyzed according to the time to maximal activity (T{sub max}) and the time to half of maximum activity (T/2). In comparison to the controls (HPI, X = 0.64.5 {+-} 0.05%) portal perfusion had slightly (X = 0.68 {+-} 0.04%), but not significantly (p > 0.05) increased. In 3 patients, the biliary phase of hepatobiliary scintigraphy showed an increased accumulation of the radiopharmaceutical in the left (n = 1) or right (n = 2) hepatic duct. The uptake of the radiopharmaceutical (T{sub max}, X = 18.5 {+-} 2.9 min) was slightly, but not significantly (p > 0.05) delayed in comparison to the controls (X = 14.2 {+-} 3.4 min), while excretion was significantly (p < 0.05) prolonged (X = 59.5 {+-} 12.1 min) (X = 34.2 {+-} 4.1 min). Intrahepatic bile flow was insignificantly (p < 0.05) prolonged (X = 31.3 {+-} 3.7 min) in comparison to the controls (X = 25.7 {+-} 3.5 min) while extrahepatic bile flow was high, significantly (p < 0.01) prolonged (X 89.0{+-} 14.3 min) than physiological one (X = 45.0 {+-} 7.2 min). Radionuclide methods are noninvasive, sensitive and valuable in monitoring liver transplants. (author)}
journal = []
issue = {1}
volume = {7}
journal type = {AC}
place = {Poland}
year = {2004}
month = {Jul}
}
title = {Single injection hepatic radionuclide angiography and hepatobiliary scintigraphy in the evaluation of liver transplant function}
author = {Obradovic, V, Artiko, V, Petrovic, N, Radevic, B, and Dapcevic, B}
abstractNote = {The aim of the study was the evaluation of the perfusion, morphology and biliary three patency of liver transplants employing two radionuclide methods. The study was performed on 10 controls and 10 patients after an orthotopic transplantation (up to two years). 'First pass' dynamic acquisition was performed with a scintillation camera, after a bolus injection of 360 MBq {sup 99m}Tc-diethyl-IDA, (60 frames/60 s), continued by a 59 minute (1 frame/min) slower dynamic study. From the liver and kidney activity during the 'first pass' study, the hepatic perfusion index (HPI) was calculated using slope-analysis. Hepatobiliary scintigrams obtained during second phase of the study were analyzed for morphology, and parenchymal and hepatobiliary TA curves were generated and analyzed according to the time to maximal activity (T{sub max}) and the time to half of maximum activity (T/2). In comparison to the controls (HPI, X = 0.64.5 {+-} 0.05%) portal perfusion had slightly (X = 0.68 {+-} 0.04%), but not significantly (p > 0.05) increased. In 3 patients, the biliary phase of hepatobiliary scintigraphy showed an increased accumulation of the radiopharmaceutical in the left (n = 1) or right (n = 2) hepatic duct. The uptake of the radiopharmaceutical (T{sub max}, X = 18.5 {+-} 2.9 min) was slightly, but not significantly (p > 0.05) delayed in comparison to the controls (X = 14.2 {+-} 3.4 min), while excretion was significantly (p < 0.05) prolonged (X = 59.5 {+-} 12.1 min) (X = 34.2 {+-} 4.1 min). Intrahepatic bile flow was insignificantly (p < 0.05) prolonged (X = 31.3 {+-} 3.7 min) in comparison to the controls (X = 25.7 {+-} 3.5 min) while extrahepatic bile flow was high, significantly (p < 0.01) prolonged (X 89.0{+-} 14.3 min) than physiological one (X = 45.0 {+-} 7.2 min). Radionuclide methods are noninvasive, sensitive and valuable in monitoring liver transplants. (author)}
journal = []
issue = {1}
volume = {7}
journal type = {AC}
place = {Poland}
year = {2004}
month = {Jul}
}