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The experimental study on radioprotective effect of genistein

Abstract

Objective: To study on the radioprotective effect of genistein on {gamma}-ray induced injury and to provide an experimental basis for the development of genistein. Methods: Male mice were fed with feedstuff which added by different does of genistein or normal diet for 2 weeks, and then irradiated once with 7.5 Gy {gamma}-rays and the difference in survival rates was observed; irradiated once with 4.0 Gy {gamma}-rays and the changes in blood cells were counted by usual method and the rates of micronuclei were determined. Results: The 30-day survival rate, blood cell counts of genistein-protected mice were all much higher than those of the control group, the protection factor reached 1.44, the rates of micronuclei of genistein-treated mice were much lower than that of control group. Conclusion: Genistein has significant radioprotective effect in mice.
Authors:
Jianquan, Wu; Hong, Jin; Zhiqin, Xu; Xianyuan, Wang; Wenkao, Nan; Peibing, Li [1] 
  1. Academy of Military Medical Sciences, Tianjin (China). Inst. of Hygiene and Environmental Medicine
Publication Date:
Sep 01, 2004
Product Type:
Journal Article
Resource Relation:
Journal Name: Chinese Journal of Radiological Health; Journal Volume: 13; Journal Issue: 3; Other Information: PBD: Sep 2004
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD PLATELETS; BONE MARROW CELLS; DYES; GAMMA RADIATION; KETONES; LEUKOCYTES; LYMPHOCYTES; MICE; RADIATION DOSES; RADIATION INJURIES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; SURVIVAL CURVES
OSTI ID:
20597494
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1004-714X; TRN: CN0501490044006
Submitting Site:
INIS
Size:
page(s) 170-172
Announcement Date:
Jun 12, 2005

Citation Formats

Jianquan, Wu, Hong, Jin, Zhiqin, Xu, Xianyuan, Wang, Wenkao, Nan, and Peibing, Li. The experimental study on radioprotective effect of genistein. China: N. p., 2004. Web.
Jianquan, Wu, Hong, Jin, Zhiqin, Xu, Xianyuan, Wang, Wenkao, Nan, & Peibing, Li. The experimental study on radioprotective effect of genistein. China.
Jianquan, Wu, Hong, Jin, Zhiqin, Xu, Xianyuan, Wang, Wenkao, Nan, and Peibing, Li. 2004. "The experimental study on radioprotective effect of genistein." China.
@misc{etde_20597494,
title = {The experimental study on radioprotective effect of genistein}
author = {Jianquan, Wu, Hong, Jin, Zhiqin, Xu, Xianyuan, Wang, Wenkao, Nan, and Peibing, Li}
abstractNote = {Objective: To study on the radioprotective effect of genistein on {gamma}-ray induced injury and to provide an experimental basis for the development of genistein. Methods: Male mice were fed with feedstuff which added by different does of genistein or normal diet for 2 weeks, and then irradiated once with 7.5 Gy {gamma}-rays and the difference in survival rates was observed; irradiated once with 4.0 Gy {gamma}-rays and the changes in blood cells were counted by usual method and the rates of micronuclei were determined. Results: The 30-day survival rate, blood cell counts of genistein-protected mice were all much higher than those of the control group, the protection factor reached 1.44, the rates of micronuclei of genistein-treated mice were much lower than that of control group. Conclusion: Genistein has significant radioprotective effect in mice.}
journal = []
issue = {3}
volume = {13}
journal type = {AC}
place = {China}
year = {2004}
month = {Sep}
}