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Functional MRI studies in children with attention deficit hyperactivity disorder

Journal Article:

Abstract

Objective: To investigate the brain activation map during Go-NoGo tasks in children with attention deficit hyperactivity disorder (ADHD) and matched controls using functional MRI. Methods: Block designed BOLD functional MRI scan covering the whole brain was performed on 10 boys having ADHD and 11 healthy boys. The 2 groups were matched by age, sex, and handedness. Executing advanced inhibitory Go-NoGo tasks served as stimuli for all subjects. The fMRI data was analyzed by SPM99 (Statistical Parametric Mapping) software with statistic t-test to generate the activation map. Results: (1) The normal children showed significant activations in left thalamus and right cingulate gyrus and fewer activations in right middle frontal gyrus during stimulate controlled Go task, but the children with ADHD showed less activations in left thalamus. (2) In response controlled Go task, the normal children showed activations in right insula, cingulate gyrus and left frontal gyrus, while the ADHD children showed lower power of response in the right middle frontal gyrus.(3) In NoGo task, right middle frontal gyrus was the dominant activated regions, and left anterior cingulate, left middle frontal gyrus and right thalamus also had some activations in normal children, while the activations of right prefrontal decreased and the thalamus  More>>
Authors:
Lei, Zhang; Zhen, Jin; Yawei, Zeng; Yan, Wang; [1]  Yufeng, Zang
  1. fMRI Center, Lab of Cognition Science and Learning, National Education Ministry and Department of Radiology, 306 Hospital of PLA, Beijing (China)
Publication Date:
Jun 01, 2004
Product Type:
Journal Article
Resource Relation:
Journal Name: Chinese Journal of Radiology; Journal Volume: 38; Journal Issue: 6; Other Information: PBD: Jun 2004
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEHAVIOR; BIOLOGICAL FUNCTIONS; BRAIN; CHILDREN; DIAGNOSIS; IMAGES; MAGNETIC RESONANCE; MENTAL DISORDERS
OSTI ID:
20593965
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Journal ID: ISSN 1005-1201; CHFSAG; TRN: CN0501273041131
Submitting Site:
INIS
Size:
page(s) 626-630
Announcement Date:
Jun 12, 2005

Journal Article:

Citation Formats

Lei, Zhang, Zhen, Jin, Yawei, Zeng, Yan, Wang, and Yufeng, Zang. Functional MRI studies in children with attention deficit hyperactivity disorder. China: N. p., 2004. Web.
Lei, Zhang, Zhen, Jin, Yawei, Zeng, Yan, Wang, & Yufeng, Zang. Functional MRI studies in children with attention deficit hyperactivity disorder. China.
Lei, Zhang, Zhen, Jin, Yawei, Zeng, Yan, Wang, and Yufeng, Zang. 2004. "Functional MRI studies in children with attention deficit hyperactivity disorder." China.
@misc{etde_20593965,
title = {Functional MRI studies in children with attention deficit hyperactivity disorder}
author = {Lei, Zhang, Zhen, Jin, Yawei, Zeng, Yan, Wang, and Yufeng, Zang}
abstractNote = {Objective: To investigate the brain activation map during Go-NoGo tasks in children with attention deficit hyperactivity disorder (ADHD) and matched controls using functional MRI. Methods: Block designed BOLD functional MRI scan covering the whole brain was performed on 10 boys having ADHD and 11 healthy boys. The 2 groups were matched by age, sex, and handedness. Executing advanced inhibitory Go-NoGo tasks served as stimuli for all subjects. The fMRI data was analyzed by SPM99 (Statistical Parametric Mapping) software with statistic t-test to generate the activation map. Results: (1) The normal children showed significant activations in left thalamus and right cingulate gyrus and fewer activations in right middle frontal gyrus during stimulate controlled Go task, but the children with ADHD showed less activations in left thalamus. (2) In response controlled Go task, the normal children showed activations in right insula, cingulate gyrus and left frontal gyrus, while the ADHD children showed lower power of response in the right middle frontal gyrus.(3) In NoGo task, right middle frontal gyrus was the dominant activated regions, and left anterior cingulate, left middle frontal gyrus and right thalamus also had some activations in normal children, while the activations of right prefrontal decreased and the thalamus increased in ADHD boys. Conclusion: In children with ADHD, some dysfunctional brain areas, mainly the prefrontal lobe and anterior cingulate gyrus were found. Thalamus was also involved according to the brain activation map.}
journal = {Chinese Journal of Radiology}
issue = {6}
volume = {38}
journal type = {AC}
place = {China}
year = {2004}
month = {Jun}
}