Abstract
Muscarinic acetylcholine receptors (mAChRs) play an important role in the generation of seizures. Single-photon emission computed tomography (SPECT) with {sup 123}I-iododexetimide (IDEX) depicts tracer uptake by mAChRs. Our aims were to: (a) determine the optimum time for interictal IDEX SPECT imaging; (b) determine the accuracy of IDEX scans in the localisation of seizure foci when compared with video EEG and MR imaging in patients with temporal lobe epilepsy (TLE); (c) characterise the distribution of IDEX binding in the temporal lobes and (d) compare IDEX SPECT and {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in identifying seizure foci. We performed sequential scans using IDEX SPECT imaging at 0, 3, 6 and 24 h in 12 consecutive patients with refractory TLE undergoing assessment for epilepsy surgery. Visual and region of interest analyses of the mesial, lateral and polar regions of the temporal lobes were used to compare IDEX SPECT, FDG PET and MR imaging in seizure onset localisation. The 6-h IDEX scan (92%; {kappa}=0.83, p=0.003) was superior to the 0-h (36%; {kappa}=0.01, p>0.05), 3-h (55%; {kappa}=0.13, p>0.05) and 24-h IDEX scans in identifying the temporal lobe of seizure origin. The 6-h IDEX scan correctly predicted the temporal lobe of seizure origin in
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Mohamed, Armin;
[1]
Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia);
University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)];
Eberl, Stefan;
Henderson, David;
Beveridge, Scott;
Constable, Chris;
[1]
Fulham, Michael J;
[1]
Kassiou, Michael;
[1]
University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)];
Zaman, Aysha;
[2]
Lo, Sing Kai
[3]
- Royal Prince Alfred Hospital, Department of PET and Nuclear Medicine, Camperdown, NSW (Australia)
- University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)
- University of Sydney, Institute of International Health, Sydney, NSW (Australia)
Citation Formats
Mohamed, Armin, Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia), University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)], Eberl, Stefan, Henderson, David, Beveridge, Scott, Constable, Chris, Fulham, Michael J, Kassiou, Michael, University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)], Zaman, Aysha, and Lo, Sing Kai.
Sequential {sup 123}I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and {sup 18}F-FDG PET imaging).
Germany: N. p.,
2005.
Web.
doi:10.1007/s00259-004-1654-2.
Mohamed, Armin, Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia), University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)], Eberl, Stefan, Henderson, David, Beveridge, Scott, Constable, Chris, Fulham, Michael J, Kassiou, Michael, University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)], Zaman, Aysha, & Lo, Sing Kai.
Sequential {sup 123}I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and {sup 18}F-FDG PET imaging).
Germany.
https://doi.org/10.1007/s00259-004-1654-2
Mohamed, Armin, Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia), University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)], Eberl, Stefan, Henderson, David, Beveridge, Scott, Constable, Chris, Fulham, Michael J, Kassiou, Michael, University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)], Zaman, Aysha, and Lo, Sing Kai.
2005.
"Sequential {sup 123}I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and {sup 18}F-FDG PET imaging)."
Germany.
https://doi.org/10.1007/s00259-004-1654-2.
@misc{etde_20590031,
title = {Sequential {sup 123}I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and {sup 18}F-FDG PET imaging)}
author = {Mohamed, Armin, Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia), University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)], Eberl, Stefan, Henderson, David, Beveridge, Scott, Constable, Chris, Fulham, Michael J, Kassiou, Michael, University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)], Zaman, Aysha, and Lo, Sing Kai}
abstractNote = {Muscarinic acetylcholine receptors (mAChRs) play an important role in the generation of seizures. Single-photon emission computed tomography (SPECT) with {sup 123}I-iododexetimide (IDEX) depicts tracer uptake by mAChRs. Our aims were to: (a) determine the optimum time for interictal IDEX SPECT imaging; (b) determine the accuracy of IDEX scans in the localisation of seizure foci when compared with video EEG and MR imaging in patients with temporal lobe epilepsy (TLE); (c) characterise the distribution of IDEX binding in the temporal lobes and (d) compare IDEX SPECT and {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in identifying seizure foci. We performed sequential scans using IDEX SPECT imaging at 0, 3, 6 and 24 h in 12 consecutive patients with refractory TLE undergoing assessment for epilepsy surgery. Visual and region of interest analyses of the mesial, lateral and polar regions of the temporal lobes were used to compare IDEX SPECT, FDG PET and MR imaging in seizure onset localisation. The 6-h IDEX scan (92%; {kappa}=0.83, p=0.003) was superior to the 0-h (36%; {kappa}=0.01, p>0.05), 3-h (55%; {kappa}=0.13, p>0.05) and 24-h IDEX scans in identifying the temporal lobe of seizure origin. The 6-h IDEX scan correctly predicted the temporal lobe of seizure origin in two patients who required intracranial EEG recordings to define the seizure onset. Reduced ligand binding was most marked at the temporal pole and mesial temporal structures. IDEX SPECT was superior to interictal FDG PET (75%; {kappa}=0.66, p=0.023) in seizure onset localisation. MR imaging was non-localising in two patients in whom it was normal and in another patient in whom there was bilateral symmetrical hippocampal atrophy. The 6-h IDEX SPECT scan is a viable alternative to FDG PET imaging in seizure onset localisation in TLE. (orig.)}
doi = {10.1007/s00259-004-1654-2}
journal = []
issue = {2}
volume = {32}
journal type = {AC}
place = {Germany}
year = {2005}
month = {Feb}
}
title = {Sequential {sup 123}I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and {sup 18}F-FDG PET imaging)}
author = {Mohamed, Armin, Royal Prince Alfred Hospital, Comprehensive Epilepsy Service, Camperdown, NSW (Australia), University of Sydney, Faculty of Medicine, Sydney, NSW (Australia)], Eberl, Stefan, Henderson, David, Beveridge, Scott, Constable, Chris, Fulham, Michael J, Kassiou, Michael, University of Sydney, Department of Pharmacology, Sydney, NSW (Australia)], Zaman, Aysha, and Lo, Sing Kai}
abstractNote = {Muscarinic acetylcholine receptors (mAChRs) play an important role in the generation of seizures. Single-photon emission computed tomography (SPECT) with {sup 123}I-iododexetimide (IDEX) depicts tracer uptake by mAChRs. Our aims were to: (a) determine the optimum time for interictal IDEX SPECT imaging; (b) determine the accuracy of IDEX scans in the localisation of seizure foci when compared with video EEG and MR imaging in patients with temporal lobe epilepsy (TLE); (c) characterise the distribution of IDEX binding in the temporal lobes and (d) compare IDEX SPECT and {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in identifying seizure foci. We performed sequential scans using IDEX SPECT imaging at 0, 3, 6 and 24 h in 12 consecutive patients with refractory TLE undergoing assessment for epilepsy surgery. Visual and region of interest analyses of the mesial, lateral and polar regions of the temporal lobes were used to compare IDEX SPECT, FDG PET and MR imaging in seizure onset localisation. The 6-h IDEX scan (92%; {kappa}=0.83, p=0.003) was superior to the 0-h (36%; {kappa}=0.01, p>0.05), 3-h (55%; {kappa}=0.13, p>0.05) and 24-h IDEX scans in identifying the temporal lobe of seizure origin. The 6-h IDEX scan correctly predicted the temporal lobe of seizure origin in two patients who required intracranial EEG recordings to define the seizure onset. Reduced ligand binding was most marked at the temporal pole and mesial temporal structures. IDEX SPECT was superior to interictal FDG PET (75%; {kappa}=0.66, p=0.023) in seizure onset localisation. MR imaging was non-localising in two patients in whom it was normal and in another patient in whom there was bilateral symmetrical hippocampal atrophy. The 6-h IDEX SPECT scan is a viable alternative to FDG PET imaging in seizure onset localisation in TLE. (orig.)}
doi = {10.1007/s00259-004-1654-2}
journal = []
issue = {2}
volume = {32}
journal type = {AC}
place = {Germany}
year = {2005}
month = {Feb}
}