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The radiochemistry of [{sup 18} F]-FDG: the first experience in Mexico; La radioquimica del [{sup 18} F]-FDG: la primera experiencia en Mexico

Abstract

The present work describes the more used method for the synthesis of 2 - [{sup 18} F] - fluorine-2-deoxy-D-glucose that is the more used radiopharmaceutical in the nuclear medicine in the cancer diagnostic. The process consists on two chemical reactions: i) [{sup 18} F{sup -}] - nucleophilic radio fluorination and i i) a hydrolysis catalyzed by acid. The first reaction incorporates to the [{sup 18} F]- fluorine labelled inside the organic precursor 1,3,4,6-tetra- O -acetil-2- O-trifluoromethanesulfonyl- {beta}-D-mannopyranose (triflate of mannose). The mechanism of this reaction is a bimolecular nucleophilic substitution (SN{sub 2}) with the ion [{sup 18} F{sup -}] - fluoride; in the second reaction, the hydrolysis of those protective acetyl groups generate the hydroxyl groups free of the [{sup 18} F]-FDG. The process includes an azeotropic distillation and several purification steps. (Author)
Authors:
Lopez D, F A [1] 
  1. Unidad PET-Ciclotron, Facultad de Medicina, UNAM, Av. Universidad 3000, Ciudad Universitaria, Coyoacan, 04500 Mexico, D. F. (Mexico)
Publication Date:
Jul 01, 2004
Product Type:
Conference
Report Number:
INIS-MX-1684
Resource Relation:
Conference: 15. Annual Congress of the SNM; 22. Annual Meeting of the SMSR; International Joint Meeting Cancun 2004; International Conjunct Congress Cancun 2004; 2004 LAS/ANS Symposium, Cancun (Mexico), 11-14 Jul 2004; Other Information: PBD: 2004
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ANNIHILATION; ANTIMETABOLITES; CHEMICAL REACTIONS; DIAGNOSIS; FLUORINE 18; FLUORINE IONS; FLUORODEOXYGLUCOSE; HYDROLYSIS; INORGANIC ACIDS; MEV RANGE; MEXICO; NEOPLASMS; NUCLEAR MEDICINE; NUCLEAR REACTIONS; POSITRON COMPUTED TOMOGRAPHY; RADIOCHEMISTRY; RADIOISOTOPES; RADIOPHARMACEUTICALS
OSTI ID:
20587596
Research Organizations:
Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de Mexico (Mexico); Comision Nacional de Seguridad Nuclear y Salvaguardias, Mexico D.F. (Mexico); Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Comision Federal de Electricidad, Gerencia de Centrales Nucleoelectricas, Mexico D.F. (Mexico)
Country of Origin:
Mexico
Language:
Spanish
Other Identifying Numbers:
TRN: MX0500070036706
Availability:
Available from INIS in electronic form
Submitting Site:
MXN
Size:
14 pages
Announcement Date:

Citation Formats

Lopez D, F A. The radiochemistry of [{sup 18} F]-FDG: the first experience in Mexico; La radioquimica del [{sup 18} F]-FDG: la primera experiencia en Mexico. Mexico: N. p., 2004. Web.
Lopez D, F A. The radiochemistry of [{sup 18} F]-FDG: the first experience in Mexico; La radioquimica del [{sup 18} F]-FDG: la primera experiencia en Mexico. Mexico.
Lopez D, F A. 2004. "The radiochemistry of [{sup 18} F]-FDG: the first experience in Mexico; La radioquimica del [{sup 18} F]-FDG: la primera experiencia en Mexico." Mexico.
@misc{etde_20587596,
title = {The radiochemistry of [{sup 18} F]-FDG: the first experience in Mexico; La radioquimica del [{sup 18} F]-FDG: la primera experiencia en Mexico}
author = {Lopez D, F A}
abstractNote = {The present work describes the more used method for the synthesis of 2 - [{sup 18} F] - fluorine-2-deoxy-D-glucose that is the more used radiopharmaceutical in the nuclear medicine in the cancer diagnostic. The process consists on two chemical reactions: i) [{sup 18} F{sup -}] - nucleophilic radio fluorination and i i) a hydrolysis catalyzed by acid. The first reaction incorporates to the [{sup 18} F]- fluorine labelled inside the organic precursor 1,3,4,6-tetra- O -acetil-2- O-trifluoromethanesulfonyl- {beta}-D-mannopyranose (triflate of mannose). The mechanism of this reaction is a bimolecular nucleophilic substitution (SN{sub 2}) with the ion [{sup 18} F{sup -}] - fluoride; in the second reaction, the hydrolysis of those protective acetyl groups generate the hydroxyl groups free of the [{sup 18} F]-FDG. The process includes an azeotropic distillation and several purification steps. (Author)}
place = {Mexico}
year = {2004}
month = {Jul}
}