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Quantal health effects for a combination of several toxic agents

Abstract

Quantal health effects caused by the combined action of a number of toxic agents are modeled using the information available for each toxicant acting in isolation. Two basic models are used; one assumes no interaction, the other postulates a separable kind of interaction in which each agent contributes an enhancement factor independent of all other agents. These two models provide yardsticks by which to measure synergisms and antagonisms in the interaction between the effects of toxic agents. Equations are given in approximations for small and large values of the risk. (author)
Authors:
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 8 refs, 3 figs; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
60 APPLIED LIFE SCIENCES; EQUATIONS; HEALTH HAZARDS; PUBLIC HEALTH; RADIATION PROTECTION; RISK ASSESSMENT; TOXIC MATERIALS
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547845
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1411003675
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 502-509
Announcement Date:

Citation Formats

Seiler, F A. Quantal health effects for a combination of several toxic agents. IAEA: N. p., 1988. Web.
Seiler, F A. Quantal health effects for a combination of several toxic agents. IAEA.
Seiler, F A. 1988. "Quantal health effects for a combination of several toxic agents." IAEA.
@misc{etde_20547845,
title = {Quantal health effects for a combination of several toxic agents}
author = {Seiler, F A}
abstractNote = {Quantal health effects caused by the combined action of a number of toxic agents are modeled using the information available for each toxicant acting in isolation. Two basic models are used; one assumes no interaction, the other postulates a separable kind of interaction in which each agent contributes an enhancement factor independent of all other agents. These two models provide yardsticks by which to measure synergisms and antagonisms in the interaction between the effects of toxic agents. Equations are given in approximations for small and large values of the risk. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}