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The pulmonary response of the aged dog to pneumococcus: Preliminary findings

Abstract

Pneumonia in the elderly can be fatal, especially in those individuals with other under- lying diseases. Several factors are involved in the increased susceptibility to pneumonia with increasing age; the loss of the immune competency may contribute significantly. The goal of this study was to expose a selected lung lobe in young and senescent dogs to 10{sup 8} cfu/mL of viable pneumococcus and to compare inflammatory and immune responses. The inflammatory response appeared to be equal in both young and aged dogs; however, the young dogs showed a large influx of lymphocytes In the immunized lobe that was not found in the aged dogs. (author)
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 7 refs, 4 figs; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
60 APPLIED LIFE SCIENCES; DOGS; LUNGS; LYMPHOCYTES; PNEUMOCOCCUS; PNEUMONIA
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547839
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1405003669
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 464-468
Announcement Date:
Feb 01, 2005

Citation Formats

King-Herbert, A P, Bice, D E, Muggenburg, B A, Haley, P J, and Merlin, T L. The pulmonary response of the aged dog to pneumococcus: Preliminary findings. IAEA: N. p., 1988. Web.
King-Herbert, A P, Bice, D E, Muggenburg, B A, Haley, P J, & Merlin, T L. The pulmonary response of the aged dog to pneumococcus: Preliminary findings. IAEA.
King-Herbert, A P, Bice, D E, Muggenburg, B A, Haley, P J, and Merlin, T L. 1988. "The pulmonary response of the aged dog to pneumococcus: Preliminary findings." IAEA.
@misc{etde_20547839,
title = {The pulmonary response of the aged dog to pneumococcus: Preliminary findings}
author = {King-Herbert, A P, Bice, D E, Muggenburg, B A, Haley, P J, and Merlin, T L}
abstractNote = {Pneumonia in the elderly can be fatal, especially in those individuals with other under- lying diseases. Several factors are involved in the increased susceptibility to pneumonia with increasing age; the loss of the immune competency may contribute significantly. The goal of this study was to expose a selected lung lobe in young and senescent dogs to 10{sup 8} cfu/mL of viable pneumococcus and to compare inflammatory and immune responses. The inflammatory response appeared to be equal in both young and aged dogs; however, the young dogs showed a large influx of lymphocytes In the immunized lobe that was not found in the aged dogs. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}