Abstract
The mechanisms responsible for recruitment of lymphocytes into the lung are not known. Data suggest that interleukin-1 (IL-1) is chemotactic for neutrophils (PMN), macrophages, and lymphocytes. Therefore, the release of IL-1 in the lung in response to antigen exposure might be important in lymphocyte recruitment. The data from this study indicate that the instillation of a low dose of human IL-lb (50 ng) into lung lobes of dogs recruited only PMN with no increase in lymphocytes. A dose of 2000 ng recruited large numbers of PMN, with a slightly increased number of lymphocytes. The instillation of 2000 ny of IL-1 into the lungs of dogs that were immunized with sheep red blood cells did not result in the recruitment of antibody-forming cells (AFC) into the treated lung lobe. These data do not support the hypothesis that IL-1 by itself is chemotactic for lymphocytes in vivo, or that inflammation induced by IL-1 alone allows the entry of APC and antibody at the same level as in lung lobes instilled with antigen. (author)
Citation Formats
Bice, D E, King-Herbert, A P, Morris, M J, Hanna, N, and Haley, P J.
The effect of in-vivo interleukin-1 on recruitment of immune cells into the lung.
IAEA: N. p.,
1988.
Web.
Bice, D E, King-Herbert, A P, Morris, M J, Hanna, N, & Haley, P J.
The effect of in-vivo interleukin-1 on recruitment of immune cells into the lung.
IAEA.
Bice, D E, King-Herbert, A P, Morris, M J, Hanna, N, and Haley, P J.
1988.
"The effect of in-vivo interleukin-1 on recruitment of immune cells into the lung."
IAEA.
@misc{etde_20547836,
title = {The effect of in-vivo interleukin-1 on recruitment of immune cells into the lung}
author = {Bice, D E, King-Herbert, A P, Morris, M J, Hanna, N, and Haley, P J}
abstractNote = {The mechanisms responsible for recruitment of lymphocytes into the lung are not known. Data suggest that interleukin-1 (IL-1) is chemotactic for neutrophils (PMN), macrophages, and lymphocytes. Therefore, the release of IL-1 in the lung in response to antigen exposure might be important in lymphocyte recruitment. The data from this study indicate that the instillation of a low dose of human IL-lb (50 ng) into lung lobes of dogs recruited only PMN with no increase in lymphocytes. A dose of 2000 ng recruited large numbers of PMN, with a slightly increased number of lymphocytes. The instillation of 2000 ny of IL-1 into the lungs of dogs that were immunized with sheep red blood cells did not result in the recruitment of antibody-forming cells (AFC) into the treated lung lobe. These data do not support the hypothesis that IL-1 by itself is chemotactic for lymphocytes in vivo, or that inflammation induced by IL-1 alone allows the entry of APC and antibody at the same level as in lung lobes instilled with antigen. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}
title = {The effect of in-vivo interleukin-1 on recruitment of immune cells into the lung}
author = {Bice, D E, King-Herbert, A P, Morris, M J, Hanna, N, and Haley, P J}
abstractNote = {The mechanisms responsible for recruitment of lymphocytes into the lung are not known. Data suggest that interleukin-1 (IL-1) is chemotactic for neutrophils (PMN), macrophages, and lymphocytes. Therefore, the release of IL-1 in the lung in response to antigen exposure might be important in lymphocyte recruitment. The data from this study indicate that the instillation of a low dose of human IL-lb (50 ng) into lung lobes of dogs recruited only PMN with no increase in lymphocytes. A dose of 2000 ng recruited large numbers of PMN, with a slightly increased number of lymphocytes. The instillation of 2000 ny of IL-1 into the lungs of dogs that were immunized with sheep red blood cells did not result in the recruitment of antibody-forming cells (AFC) into the treated lung lobe. These data do not support the hypothesis that IL-1 by itself is chemotactic for lymphocytes in vivo, or that inflammation induced by IL-1 alone allows the entry of APC and antibody at the same level as in lung lobes instilled with antigen. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}