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Immunohistochemical detection of epidermal growth factor receptor in radiation-induced lung tumors in Beagle dogs

Abstract

Increased levels of epidermal growth factor receptor have been reported in a variety of tumors, including pulmonary squamous cell carcinomas in man. The purpose of this study was to determine if increased levels of epidermal growth factor (EGFR) were present in lung tumors from Beagle dogs that had been exposed to {sup 239}PuO{sub 2}- Using immunohistochemical techniques, sections from 17 lung tumors were examined for the presence of EGFR. Seven of the tumors were strongly positive for EGFR; the remainder of the tumors and the normal lung sections were negative. The positive immunostaining could not be correlated with the histologic phenotype of the tumors. Work is in progress to determine the level of EGFR in preneoplastic, proliferative epithelial foci in the Iung. (author)
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 3 refs, 1 tab; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BEAGLES; CARCINOMAS; DETECTION; GROWTH FACTORS; LUNGS; MEN; PHENOTYPE; PLUTONIUM 239; PLUTONIUM DIOXIDE; RECEPTORS
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547815
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1381003645
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 345-347
Announcement Date:

Citation Formats

Gillett, N A, Haley, P J, and Hahn, F F. Immunohistochemical detection of epidermal growth factor receptor in radiation-induced lung tumors in Beagle dogs. IAEA: N. p., 1988. Web.
Gillett, N A, Haley, P J, & Hahn, F F. Immunohistochemical detection of epidermal growth factor receptor in radiation-induced lung tumors in Beagle dogs. IAEA.
Gillett, N A, Haley, P J, and Hahn, F F. 1988. "Immunohistochemical detection of epidermal growth factor receptor in radiation-induced lung tumors in Beagle dogs." IAEA.
@misc{etde_20547815,
title = {Immunohistochemical detection of epidermal growth factor receptor in radiation-induced lung tumors in Beagle dogs}
author = {Gillett, N A, Haley, P J, and Hahn, F F}
abstractNote = {Increased levels of epidermal growth factor receptor have been reported in a variety of tumors, including pulmonary squamous cell carcinomas in man. The purpose of this study was to determine if increased levels of epidermal growth factor (EGFR) were present in lung tumors from Beagle dogs that had been exposed to {sup 239}PuO{sub 2}- Using immunohistochemical techniques, sections from 17 lung tumors were examined for the presence of EGFR. Seven of the tumors were strongly positive for EGFR; the remainder of the tumors and the normal lung sections were negative. The positive immunostaining could not be correlated with the histologic phenotype of the tumors. Work is in progress to determine the level of EGFR in preneoplastic, proliferative epithelial foci in the Iung. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}