Abstract
Ten radiation-induced and three spontaneous lung tumors were analyzed for aberrant expression of known oncogenes. In 12 of 13 tumors tested, sequences hybridizing to the c-myc oncogene were expressed at levels 1.5 times higher than sequences hybridizing to {beta}-actin. This level of oncogene expression was also observed in 9 of 13 tumors for 1 or more members of the ras family of oncogenes. Seven of thirteen tumors examined express sequences that hybridize with clones of v-ros or c-met. The ros and met clones both code for oncogenes whose normal homologues are transmembrane proteins related to the insulin receptor. (author)
Citation Formats
Kelly, G, Kerkof, P R, and Haley, P J.
Oncogene expression in primary lung tumors in dogs that inhaled {sup 239}PuO{sub 2}.
IAEA: N. p.,
1988.
Web.
Kelly, G, Kerkof, P R, & Haley, P J.
Oncogene expression in primary lung tumors in dogs that inhaled {sup 239}PuO{sub 2}.
IAEA.
Kelly, G, Kerkof, P R, and Haley, P J.
1988.
"Oncogene expression in primary lung tumors in dogs that inhaled {sup 239}PuO{sub 2}."
IAEA.
@misc{etde_20547813,
title = {Oncogene expression in primary lung tumors in dogs that inhaled {sup 239}PuO{sub 2}}
author = {Kelly, G, Kerkof, P R, and Haley, P J}
abstractNote = {Ten radiation-induced and three spontaneous lung tumors were analyzed for aberrant expression of known oncogenes. In 12 of 13 tumors tested, sequences hybridizing to the c-myc oncogene were expressed at levels 1.5 times higher than sequences hybridizing to {beta}-actin. This level of oncogene expression was also observed in 9 of 13 tumors for 1 or more members of the ras family of oncogenes. Seven of thirteen tumors examined express sequences that hybridize with clones of v-ros or c-met. The ros and met clones both code for oncogenes whose normal homologues are transmembrane proteins related to the insulin receptor. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}
title = {Oncogene expression in primary lung tumors in dogs that inhaled {sup 239}PuO{sub 2}}
author = {Kelly, G, Kerkof, P R, and Haley, P J}
abstractNote = {Ten radiation-induced and three spontaneous lung tumors were analyzed for aberrant expression of known oncogenes. In 12 of 13 tumors tested, sequences hybridizing to the c-myc oncogene were expressed at levels 1.5 times higher than sequences hybridizing to {beta}-actin. This level of oncogene expression was also observed in 9 of 13 tumors for 1 or more members of the ras family of oncogenes. Seven of thirteen tumors examined express sequences that hybridize with clones of v-ros or c-met. The ros and met clones both code for oncogenes whose normal homologues are transmembrane proteins related to the insulin receptor. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}