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Inhaled {sup 239}PuO{sub 2} in rats with pulmonary emphysema. II

Abstract

The modifying effects of pre-existing pulmonary emphysema on deposition, distribution, retention, and effects of inhaled {sup 239}PuO{sub 2} in the rat were investigated. The presence of emphysema in the rats tested was indicated by respiratory function measurements and confirmed microscopically. Initial lung burdens of {sup 239}Pu per kg body weight were less in rats with emphysema than in control rats; however, the retention of {sup 239}Pu was similar in emphysematous and control rats. Survival and lung tumor occurrence were similar in emphysematous and control rats exposed to {sup 239}PuO{sub 2}. We concluded that rats with pre-existing pulmonary emphysema were not more sensitive to the effects of inhaled {sup 239}PuO{sub 2} than control rats. (author)
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 4 refs, 2 figs, 4 tabs; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL ACCUMULATION; DEPOSITION; EMPHYSEMA; LUNGS; NEOPLASMS; PLUTONIUM 239; RADIONUCLIDE KINETICS; RATS; RETENTION
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547800
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1366003630
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 262-268
Announcement Date:

Citation Formats

Lundgren, D L, Mauderly, J L, Carlton, W W, and Hahn, F F. Inhaled {sup 239}PuO{sub 2} in rats with pulmonary emphysema. II. IAEA: N. p., 1988. Web.
Lundgren, D L, Mauderly, J L, Carlton, W W, & Hahn, F F. Inhaled {sup 239}PuO{sub 2} in rats with pulmonary emphysema. II. IAEA.
Lundgren, D L, Mauderly, J L, Carlton, W W, and Hahn, F F. 1988. "Inhaled {sup 239}PuO{sub 2} in rats with pulmonary emphysema. II." IAEA.
@misc{etde_20547800,
title = {Inhaled {sup 239}PuO{sub 2} in rats with pulmonary emphysema. II}
author = {Lundgren, D L, Mauderly, J L, Carlton, W W, and Hahn, F F}
abstractNote = {The modifying effects of pre-existing pulmonary emphysema on deposition, distribution, retention, and effects of inhaled {sup 239}PuO{sub 2} in the rat were investigated. The presence of emphysema in the rats tested was indicated by respiratory function measurements and confirmed microscopically. Initial lung burdens of {sup 239}Pu per kg body weight were less in rats with emphysema than in control rats; however, the retention of {sup 239}Pu was similar in emphysematous and control rats. Survival and lung tumor occurrence were similar in emphysematous and control rats exposed to {sup 239}PuO{sub 2}. We concluded that rats with pre-existing pulmonary emphysema were not more sensitive to the effects of inhaled {sup 239}PuO{sub 2} than control rats. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}