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Toxicokinetics of beryllium following inhalation of beryllium oxide by Beagle dogs. III

Abstract

Young adult Beagle dogs inhaled radiolabeled beryllium oxide aerosols ({sup 7}BeO) prepared at either 500 deg. or 1000 deg. C to achieve one of two initial lung burdens (ILBs) of BeO. After exposure, animals were monitored by whole body counting for {sup 7}Be, and excreta, clinical, and radiographic data were collected. One group of dogs was assigned for serial sacrifice for quantitation of beryllium clearance from lung, translocation to other organs, and histopathologic analysis of lung and lymph nodes. A second group of dogs was subjected to periodic bronchopulmonary lavage for analysis of lymphocyte responsiveness to beryllium. These latter dogs were subsequently re-exposed to the high ILB level of BeO prepared t 500 deg. C. ILBs following the second exposure were higher than that after the first exposure (74 vs. 42 {mu}g BeO/kg, respectively). Except for one dog that exhibited enhanced beryllium retention after the second exposure, patterns of whole body clearance were similar to those observed after the initial exposures to the 500 deg. C-BeO. Analysis of lymphocyte responsiveness to beryllium in the second group of dogs is continuing. (author)
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 3 refs, 2 figs, 2 tabs; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
60 APPLIED LIFE SCIENCES; ADULTS; AEROSOLS; BEAGLES; BERYLLIUM OXIDES; CLEARANCE; INHALATION; LUNGS; LYMPH NODES; LYMPHOCYTES; PERIODICITY; RETENTION; WHOLE-BODY COUNTING
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547776
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1342003606
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 118-122
Announcement Date:

Citation Formats

Finch, G L, Haley, P J, Hoover, M D, Mewhinney, J A, Bice, D E, and Eidson, A F. Toxicokinetics of beryllium following inhalation of beryllium oxide by Beagle dogs. III. IAEA: N. p., 1988. Web.
Finch, G L, Haley, P J, Hoover, M D, Mewhinney, J A, Bice, D E, & Eidson, A F. Toxicokinetics of beryllium following inhalation of beryllium oxide by Beagle dogs. III. IAEA.
Finch, G L, Haley, P J, Hoover, M D, Mewhinney, J A, Bice, D E, and Eidson, A F. 1988. "Toxicokinetics of beryllium following inhalation of beryllium oxide by Beagle dogs. III." IAEA.
@misc{etde_20547776,
title = {Toxicokinetics of beryllium following inhalation of beryllium oxide by Beagle dogs. III}
author = {Finch, G L, Haley, P J, Hoover, M D, Mewhinney, J A, Bice, D E, and Eidson, A F}
abstractNote = {Young adult Beagle dogs inhaled radiolabeled beryllium oxide aerosols ({sup 7}BeO) prepared at either 500 deg. or 1000 deg. C to achieve one of two initial lung burdens (ILBs) of BeO. After exposure, animals were monitored by whole body counting for {sup 7}Be, and excreta, clinical, and radiographic data were collected. One group of dogs was assigned for serial sacrifice for quantitation of beryllium clearance from lung, translocation to other organs, and histopathologic analysis of lung and lymph nodes. A second group of dogs was subjected to periodic bronchopulmonary lavage for analysis of lymphocyte responsiveness to beryllium. These latter dogs were subsequently re-exposed to the high ILB level of BeO prepared t 500 deg. C. ILBs following the second exposure were higher than that after the first exposure (74 vs. 42 {mu}g BeO/kg, respectively). Except for one dog that exhibited enhanced beryllium retention after the second exposure, patterns of whole body clearance were similar to those observed after the initial exposures to the 500 deg. C-BeO. Analysis of lymphocyte responsiveness to beryllium in the second group of dogs is continuing. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}