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Deposition of cigarette smoke particles in the rat respiratory tract

Abstract

Male and female rats were exposed to mainstream cigarette smoke to determine the fractional deposition. Deposition studies were conducted by placing the rats in plethysmography tubes for respiratory minute volume measurements and exposing them to {sup 14}C-dotriacontane-labeled cigarette smoke at mass concentrations of 202 or 624 mg/m{sup 3} for 25 min. Immediately after the exposure, the rats were sacrificed and the 14{sub C} contents in various tissues and organs were analyzed. Results showed that the GI tract contained 16-31% of the total activity, indicating significant clearance from the large airways and nose to the GI tract during the exposure and during the 10-15 min between cessation of the exposure and the removal of the organs. Total deposition of the inhaled activity was 20.1 {+-} 1.6% for both exposure concentrations. The intrapulmonary deposition fractions (lung lobes plus airways below the lobar bronchi) were 12.4 {+-} 0.9% and 15.9 {+-} 1.4% for high and low concentrations, respectively, suggesting a slight enhancement in upper airway deposition for animals exposed to the higher smoke concentration. (author)
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: 8 refs, 3 figs, 2 tabs; PBD: Dec 1988; Related Information: In: Inhalation Toxicology Research Institute annual report 1987-1988, by Mauderly, J.L.; Mewhinney, J.A.; Bechtold, W.E.; Sun, J.D.; Coons, T.A. (eds.), 659 pages.
Subject:
60 APPLIED LIFE SCIENCES; BRONCHI; CARBON 14; CLEARANCE; DEPOSITION; LUNGS; NOSE; PARTICLES; RATS; TOBACCO SMOKES
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547768
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1334003598
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 72-77
Announcement Date:
Feb 01, 2005

Citation Formats

Chen, B T, Weber, R E, Yeh, H C, Lundgren, D L, Snipes, M B, and Mauderly, J L. Deposition of cigarette smoke particles in the rat respiratory tract. IAEA: N. p., 1988. Web.
Chen, B T, Weber, R E, Yeh, H C, Lundgren, D L, Snipes, M B, & Mauderly, J L. Deposition of cigarette smoke particles in the rat respiratory tract. IAEA.
Chen, B T, Weber, R E, Yeh, H C, Lundgren, D L, Snipes, M B, and Mauderly, J L. 1988. "Deposition of cigarette smoke particles in the rat respiratory tract." IAEA.
@misc{etde_20547768,
title = {Deposition of cigarette smoke particles in the rat respiratory tract}
author = {Chen, B T, Weber, R E, Yeh, H C, Lundgren, D L, Snipes, M B, and Mauderly, J L}
abstractNote = {Male and female rats were exposed to mainstream cigarette smoke to determine the fractional deposition. Deposition studies were conducted by placing the rats in plethysmography tubes for respiratory minute volume measurements and exposing them to {sup 14}C-dotriacontane-labeled cigarette smoke at mass concentrations of 202 or 624 mg/m{sup 3} for 25 min. Immediately after the exposure, the rats were sacrificed and the 14{sub C} contents in various tissues and organs were analyzed. Results showed that the GI tract contained 16-31% of the total activity, indicating significant clearance from the large airways and nose to the GI tract during the exposure and during the 10-15 min between cessation of the exposure and the removal of the organs. Total deposition of the inhaled activity was 20.1 {+-} 1.6% for both exposure concentrations. The intrapulmonary deposition fractions (lung lobes plus airways below the lobar bronchi) were 12.4 {+-} 0.9% and 15.9 {+-} 1.4% for high and low concentrations, respectively, suggesting a slight enhancement in upper airway deposition for animals exposed to the higher smoke concentration. (author)}
place = {IAEA}
year = {1988}
month = {Dec}
}