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Inhalation Toxicology Research Institute annual report 1987-1988

Abstract

The mission of the Inhalation Toxicology Research Institute is to investigate the magnitude of human health effects that result from the inhalation of airborne materials at home, in the work place, or in the general environment. Diseases of the respiratory tract are major causes of suffering and death, and many of these diseases are directly related to the materials that people breath. The Institute's research is directed toward obtaining a better understanding of the basic biology of the respiratory tract and the mechanisms by which inhaled materials produce respiratory disease. Special attention is focused on studying the airborne materials released by various energy technologies, as well as those associated with national defense activities. The research uses a wide-ranging, comprehensive array of investigative approaches that are directed toward characterizing the source of the airborne material, following the material through its potential transformation in the air, identifying the mechanisms that govern its inhalation and deposition in the respiratory tract, and determining the fate of these inhaled materials in the body and the health effects they produce. The ultimate objectives are to determine the roles played by inhaled materials in the development of disease processes adn to estimate the risk they pose by  More>>
Authors:
Mauderly, J L; Mewhinney, J A; Bechtold, W E; Sun, J D; Coons, T A [1] 
  1. eds.
Publication Date:
Dec 01, 1988
Product Type:
Technical Report
Report Number:
LMF-121; INIS-XA-N-170
Resource Relation:
Other Information: Refs, figs, tabs; PBD: Dec 1988
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; 54 ENVIRONMENTAL SCIENCES; BIOLOGICAL EFFECTS; BIOLOGICAL LOCALIZATION; EXCRETION; INHALATION; INHALATION TOXICOLOGY RESEARCH INSTITUTE; LEADING ABSTRACT; PHYSIOLOGY; RADIONUCLIDE KINETICS; TOXIC MATERIALS; TOXICITY
Sponsoring Organizations:
Office of Health and Environmental Research, U.S. Department of Energy (United States)
OSTI ID:
20547753
Research Organizations:
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Contract DE-AC04-76EV01013; TRN: XA04N1319003583
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
659 pages
Announcement Date:

Citation Formats

Mauderly, J L, Mewhinney, J A, Bechtold, W E, Sun, J D, and Coons, T A. Inhalation Toxicology Research Institute annual report 1987-1988. IAEA: N. p., 1988. Web.
Mauderly, J L, Mewhinney, J A, Bechtold, W E, Sun, J D, & Coons, T A. Inhalation Toxicology Research Institute annual report 1987-1988. IAEA.
Mauderly, J L, Mewhinney, J A, Bechtold, W E, Sun, J D, and Coons, T A. 1988. "Inhalation Toxicology Research Institute annual report 1987-1988." IAEA.
@misc{etde_20547753,
title = {Inhalation Toxicology Research Institute annual report 1987-1988}
author = {Mauderly, J L, Mewhinney, J A, Bechtold, W E, Sun, J D, and Coons, T A}
abstractNote = {The mission of the Inhalation Toxicology Research Institute is to investigate the magnitude of human health effects that result from the inhalation of airborne materials at home, in the work place, or in the general environment. Diseases of the respiratory tract are major causes of suffering and death, and many of these diseases are directly related to the materials that people breath. The Institute's research is directed toward obtaining a better understanding of the basic biology of the respiratory tract and the mechanisms by which inhaled materials produce respiratory disease. Special attention is focused on studying the airborne materials released by various energy technologies, as well as those associated with national defense activities. The research uses a wide-ranging, comprehensive array of investigative approaches that are directed toward characterizing the source of the airborne material, following the material through its potential transformation in the air, identifying the mechanisms that govern its inhalation and deposition in the respiratory tract, and determining the fate of these inhaled materials in the body and the health effects they produce. The ultimate objectives are to determine the roles played by inhaled materials in the development of disease processes adn to estimate the risk they pose by inhaled materials in the development of disease processes and to estimate the risk they pose to humans who may be exposed to them. This report contains brief research papers that reflect the scope and recent findings of the Institute's research funded by the U.S. Department of Energy, principally through the Office of Health and Environmental Research. The papers are divided into topical sections. The first section, Characterization of Airborne Materials and Generation of Experimental Exposure Atmospheres, reflects the Institute's capabilities for fundamental aerosol research and the application of that expertise to toxicological studies. The second section, Deposition and Fate of Inhaled Toxicants, describes factors influencing the uptake of inhaled materials and their initial interactions in the body. The third and fourth sections, Health Effects of Inhaled Radionuclides and Health Effects of Inhaled Chemical Toxicants, describe recent progress in the fields of radiation and chemical toxicology, respectively. The fifth section, Mechanisms of Carcinogenesis, reflects progress in the understanding of the mechanisms by which radiation and chemicals induce cancer. Similarly, the sixth section, Mechanisms of Non-Carcinogenic Responses to Inhaled Toxicants describes research on the development of diseases other than cancer. The seventh section, The Application of Mathematical Modeling to Health Issues, describes efforts to predict health risks by using computer-based models and limited experimental or epidemiological data. The final section, Studies at the University of Utah, describes progress in studies conducted by University of Utah scientists funded by subcontract through this Institute.}
place = {IAEA}
year = {1988}
month = {Dec}
}