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Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit; Effets d'une irradiation gamma globale non letale sur les activites electroencephalograpiques spontanees et evoquees du lapin adulte

Abstract

The whole of the experimental methods described (animal preparation, achievement of a precise physiological technique, dosimetry, biological information processing) allowed us to follow the changes for 15 days in the spontaneous and evoked electroencephalogram activities of rabbits submitted to a non-lethal 400 rads whole-body gamma-irradiation. Behavioural troubles, changes in the arousal state and the spontaneous electrical activity of the neo-cortex and hippocampus were noticed constantly together with an enhanced cortical excitability, and the appearance of elements of the paroxystic series sometimes in contrast with a general decrease in amplitude. After a visual stimulus the general morphology of evoked activities at the level of the primary visual areas and hippocampus was unchanged, but enhanced latencies and delays, less systematic modifications in amplitudes seemed to show out a direct effect of radiations on the nervous system and sensorial activities; these troubles seemed to occur independently from the basic electrical activity. As a whole, the changes observed were usually transitory and varied with each individual. Finally an assumption is made to explain the mechanism of arousal troubles and the general evolution of spontaneous electrical activity in the brain. (author) [French] 'L'ensemble des methodes experimentales decrites (preparation des animaux, mise au point d'une technique  More>>
Authors:
Court, L [1] 
  1. Commissariat a l'Energie Atomique, Fontenay-aux-Roses (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1969
Product Type:
Technical Report
Report Number:
CEA-R-3693
Resource Relation:
Other Information: 226 refs; PBD: 1969
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BRAIN; ELECTROENCEPHALOGRAPHY; GAMMA RADIATION; RABBITS; WHOLE-BODY IRRADIATION
OSTI ID:
20547192
Research Organizations:
CEA Fontenay-aux-Roses, 92 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR04R3693002799
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
[214] pages
Announcement Date:

Citation Formats

Court, L. Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit; Effets d'une irradiation gamma globale non letale sur les activites electroencephalograpiques spontanees et evoquees du lapin adulte. France: N. p., 1969. Web.
Court, L. Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit; Effets d'une irradiation gamma globale non letale sur les activites electroencephalograpiques spontanees et evoquees du lapin adulte. France.
Court, L. 1969. "Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit; Effets d'une irradiation gamma globale non letale sur les activites electroencephalograpiques spontanees et evoquees du lapin adulte." France.
@misc{etde_20547192,
title = {Effect of a non lethal whole-body gamma irradiation on the spontaneous and evoked electroencephalographic activities of the adult rabbit; Effets d'une irradiation gamma globale non letale sur les activites electroencephalograpiques spontanees et evoquees du lapin adulte}
author = {Court, L}
abstractNote = {The whole of the experimental methods described (animal preparation, achievement of a precise physiological technique, dosimetry, biological information processing) allowed us to follow the changes for 15 days in the spontaneous and evoked electroencephalogram activities of rabbits submitted to a non-lethal 400 rads whole-body gamma-irradiation. Behavioural troubles, changes in the arousal state and the spontaneous electrical activity of the neo-cortex and hippocampus were noticed constantly together with an enhanced cortical excitability, and the appearance of elements of the paroxystic series sometimes in contrast with a general decrease in amplitude. After a visual stimulus the general morphology of evoked activities at the level of the primary visual areas and hippocampus was unchanged, but enhanced latencies and delays, less systematic modifications in amplitudes seemed to show out a direct effect of radiations on the nervous system and sensorial activities; these troubles seemed to occur independently from the basic electrical activity. As a whole, the changes observed were usually transitory and varied with each individual. Finally an assumption is made to explain the mechanism of arousal troubles and the general evolution of spontaneous electrical activity in the brain. (author) [French] 'L'ensemble des methodes experimentales decrites (preparation des animaux, mise au point d'une technique physiologique precise, dosimetrie, traitement de l'information biologique) a permis de suivre, pendant 15 jours, chez le lapin soumis a une irradiation gamma globale non letale de 400 rads, les modifications des activites electroencephaliques spontanees et evoquees. De facon constante, on note des troubles du comportement, des modifications de la vigilance et de l'activite electrique spontanee du neo-cortex et de l'hippocampe, ainsi qu'une augmentation de l'excitabilite corticale, l'apparition d'elements de la serie paroxystique contrastant parfois avec une diminution generale de l'amplitude. La morphologie generale des activites evoquees recueillies au niveau des aires visuelles primaires et de l'hippocampe, apres stimulation visuelle n'est pas modifiee, mais l'augmentation des latences et des delais, les modifications moins systematiques des amplitudes paraissent temoigner d'un effet direct des radiations sur le systeme nerveux et les voies sensorielles; ces anomalies paraissent independantes de l'activite electrique de base. L'ensemble des modifications observees est, en general, transitoire et varie selon les animaux. Enfin, est posee l'hypothese expliquant le mecanisme des troubles de la vigilance et l'evolution generale de l'activite electrique cerebrale spontanee. (auteur)}
place = {France}
year = {1969}
month = {Jul}
}