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Radioprotective properties of certain nitrogenous compounds heterocyclic on the serum proteins of irradiated mice; Proprietes radioprotectrices de certains heterocycles azotes sur les proteines seriques de souris irradiees

Abstract

The results obtained from this study suggest the following: the concentration of total serum proteins in mice is very little changed during all the treatments carried out, while protein fractions showed significant alterations. The concentrations of various serum proteins remain almost constant under normal conditions. Intraperitoneal administration of imidazole or benzimidazole at the mentioned doses induces rapid quantitative changes in the serum which are recovered in about 3 days Whole-body X-irradiation at 750 roentgens creates slow but progressive and persisting serious changes in a concentration of serum protein fractions which end by death of animals at the 8 - 10. day after irradiation. Whole-body X-irradiation of imidazole or benzimidazole protected animals results in quantitative rapid changes in concentration of serum protein fractions, for about four days after which a slow but steady restoration begins. The concentration approaches the normal levels towards the 10. day after irradiation. Imidazole and benzimidazole were proved to be good radio-protectants against the effects of radiation on serum protein fractions. Benzimidazole seems to surpass imidazole. (authors) [French] L'action radioprotectrice de l'imidazole et du benzimidazole a ete mise en evidence dans des travaux anterieurs. Dans ce travail cette action est etudiee au niveau des proteines seriques de  More>>
Authors:
Pierotti, T; Roushdy, H; Polverelli, M; Mazza, M [1] 
  1. Commissariat a l'Energie Atomique, Grenoble (France). Centre d'Etudes Nucleaires
Publication Date:
Jul 01, 1969
Product Type:
Technical Report
Report Number:
CEA-R-3679
Resource Relation:
Other Information: PBD: 1969
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ALBUMINS; BENZIMIDAZOLES; BIOLOGICAL RADIATION EFFECTS; BLOOD SERUM; GLOBULINS; IMIDAZOLES; RADIOPROTECTIVE SUBSTANCES
OSTI ID:
20528709
Research Organizations:
CEA Grenoble, 38 (France)
Country of Origin:
France
Language:
French
Other Identifying Numbers:
TRN: FR04R3679094975
Availability:
Available from INIS in electronic form
Submitting Site:
FRN
Size:
[26] pages
Announcement Date:

Citation Formats

Pierotti, T, Roushdy, H, Polverelli, M, and Mazza, M. Radioprotective properties of certain nitrogenous compounds heterocyclic on the serum proteins of irradiated mice; Proprietes radioprotectrices de certains heterocycles azotes sur les proteines seriques de souris irradiees. France: N. p., 1969. Web.
Pierotti, T, Roushdy, H, Polverelli, M, & Mazza, M. Radioprotective properties of certain nitrogenous compounds heterocyclic on the serum proteins of irradiated mice; Proprietes radioprotectrices de certains heterocycles azotes sur les proteines seriques de souris irradiees. France.
Pierotti, T, Roushdy, H, Polverelli, M, and Mazza, M. 1969. "Radioprotective properties of certain nitrogenous compounds heterocyclic on the serum proteins of irradiated mice; Proprietes radioprotectrices de certains heterocycles azotes sur les proteines seriques de souris irradiees." France.
@misc{etde_20528709,
title = {Radioprotective properties of certain nitrogenous compounds heterocyclic on the serum proteins of irradiated mice; Proprietes radioprotectrices de certains heterocycles azotes sur les proteines seriques de souris irradiees}
author = {Pierotti, T, Roushdy, H, Polverelli, M, and Mazza, M}
abstractNote = {The results obtained from this study suggest the following: the concentration of total serum proteins in mice is very little changed during all the treatments carried out, while protein fractions showed significant alterations. The concentrations of various serum proteins remain almost constant under normal conditions. Intraperitoneal administration of imidazole or benzimidazole at the mentioned doses induces rapid quantitative changes in the serum which are recovered in about 3 days Whole-body X-irradiation at 750 roentgens creates slow but progressive and persisting serious changes in a concentration of serum protein fractions which end by death of animals at the 8 - 10. day after irradiation. Whole-body X-irradiation of imidazole or benzimidazole protected animals results in quantitative rapid changes in concentration of serum protein fractions, for about four days after which a slow but steady restoration begins. The concentration approaches the normal levels towards the 10. day after irradiation. Imidazole and benzimidazole were proved to be good radio-protectants against the effects of radiation on serum protein fractions. Benzimidazole seems to surpass imidazole. (authors) [French] L'action radioprotectrice de l'imidazole et du benzimidazole a ete mise en evidence dans des travaux anterieurs. Dans ce travail cette action est etudiee au niveau des proteines seriques de souris irradiees. Les resultats obtenus sont les suivants: pas de variation notable de la concentration des proteines totales quel que soit le traitement applique, mais variations importantes de chaque fraction proteinique. Apres injection intraperitoneale des radioprotecteurs on assiste a de brusques variations de la concentration des proteines du serum, variations qui s'estompent trois jours apres l'injection. L'irradiation in toto a 750 roentgens entraine aussi de profonds changements de concentration des proteines du serum que l'on observe du jour de l'irradiation jusqu'a la mort des animaux. Chez les animaux irradies et proteges par les heterocycles azotes, des le quatrieme jour apres l'irradiation la restauration s'amorce et au bout de dix jours, on retrouve les concentrations normales pour chaque fraction proteinique. Le benzimidazole apparait comme un meilleur radioprotecteur que l'imidazole. (auteurs)}
place = {France}
year = {1969}
month = {Jul}
}