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Treatment of children with Helicobacter pylori infection and malabsorption syndrome with probiotics: Comparison with conventional method

Abstract

Helicobacter pylori infection is one of the most common bacterial infection (82 %) in Senegal where malnutrition is common in children (25 %). Our aims were to definite prevalence of H. pylori, to determine the relationship between Hp infection and undernourishment and to verify the efficiency of treatment with probiotic. In some studies a positive effect of Saccharomyces boulardii has been demonstrated against H. pylori. We have included healthy children 7 to 10 years of age. 108 out of 129 (84%) were H. pylori-positive by breath-test. Two groups were randomised. Group A was treated with ten days' standard triple therapy (Omeprazole 1 mg Kg/day in single day gift, Amoxycillin 50 mg/kg/two times per day and Clarithromycin 250 mg two times per day). Group B received probiotic (250 mg of Saccharomyces boulardii with 5g Inulin three times per day) for 3 months. Evaluation of treatment was done one month after the end of therapy. Seventy one children out of 110 (64.5%) had digestive symptoms in their medical history. The main signs were recurrent abdominal pain in 64 cases. BMI were less than 18.50 in all the children with H. pylori infection without other nutritional abnormaly. Eight children were eradicated after treatment  More>>
Authors:
Ndiaye, M F; Mbengue, M; Mbaye, P S; Diouf, S; [1]  Ghoos, Y; [2]  Brunser, O [3] 
  1. Societe Senegalaise de Gasto-enterologie et d'hepatologie, Dakar (Senegal)
  2. Labo. Digestie Absorptie, Leuven (Belgium)
  3. Institute of Nutrition and Food Technology, Santiago (Chile)
Publication Date:
Jul 01, 2004
Product Type:
Conference
Report Number:
NAHRES-78
Resource Relation:
Conference: Final research co-ordination meeting on use of isotopic techniques to examine the significance of infection and other insults in early childhood to diarrhoea morbidity, mal-assimilation and failure to thrive, Vienna (Austria), 16-20 Jun 2003; Other Information: Tabs; PBD: 2004; Related Information: In: Co-ordinated research project on use of isotopic techniques to examine the significance of infection and other insults in early childhood to diarrhoea morbidity, mal-assimilation and failure to thrive. Report on the final research co-ordination meeting, 149 pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BACTERIA; BACTERIAL DISEASES; CHILDREN; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASE INCIDENCE; INULIN; SACCHAROMYCES; THERAPY
OSTI ID:
20507670
Research Organizations:
International Atomic Energy Agency, Section of Nutritional and Health-Related Environmental Studies, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0403217077122
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 119-132
Announcement Date:

Citation Formats

Ndiaye, M F, Mbengue, M, Mbaye, P S, Diouf, S, Ghoos, Y, and Brunser, O. Treatment of children with Helicobacter pylori infection and malabsorption syndrome with probiotics: Comparison with conventional method. IAEA: N. p., 2004. Web.
Ndiaye, M F, Mbengue, M, Mbaye, P S, Diouf, S, Ghoos, Y, & Brunser, O. Treatment of children with Helicobacter pylori infection and malabsorption syndrome with probiotics: Comparison with conventional method. IAEA.
Ndiaye, M F, Mbengue, M, Mbaye, P S, Diouf, S, Ghoos, Y, and Brunser, O. 2004. "Treatment of children with Helicobacter pylori infection and malabsorption syndrome with probiotics: Comparison with conventional method." IAEA.
@misc{etde_20507670,
title = {Treatment of children with Helicobacter pylori infection and malabsorption syndrome with probiotics: Comparison with conventional method}
author = {Ndiaye, M F, Mbengue, M, Mbaye, P S, Diouf, S, Ghoos, Y, and Brunser, O}
abstractNote = {Helicobacter pylori infection is one of the most common bacterial infection (82 %) in Senegal where malnutrition is common in children (25 %). Our aims were to definite prevalence of H. pylori, to determine the relationship between Hp infection and undernourishment and to verify the efficiency of treatment with probiotic. In some studies a positive effect of Saccharomyces boulardii has been demonstrated against H. pylori. We have included healthy children 7 to 10 years of age. 108 out of 129 (84%) were H. pylori-positive by breath-test. Two groups were randomised. Group A was treated with ten days' standard triple therapy (Omeprazole 1 mg Kg/day in single day gift, Amoxycillin 50 mg/kg/two times per day and Clarithromycin 250 mg two times per day). Group B received probiotic (250 mg of Saccharomyces boulardii with 5g Inulin three times per day) for 3 months. Evaluation of treatment was done one month after the end of therapy. Seventy one children out of 110 (64.5%) had digestive symptoms in their medical history. The main signs were recurrent abdominal pain in 64 cases. BMI were less than 18.50 in all the children with H. pylori infection without other nutritional abnormaly. Eight children were eradicated after treatment seven in the group under conventional treatment (58%) and one in the group under probiotics (6%). We concluded that prevalence of H. pylori infection is very high in young children as of the 7 years' age in urban as in rural environments. Symptoms are not specific. No significant difference in the nutritional state is observed between H. pylori-positive and H. pylori-negative children. Treatment by probiotics does not seem to give efficient results for eradication of H. pylori. (author)}
place = {IAEA}
year = {2004}
month = {Jul}
}