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Total body fat, proinflammatory cytokines and insulin resistance in Indian subjects

Abstract

We studied cardiovascular risk factors in 30 to 50 year old Indian men in three geographical locations (rural, urban slums and urban middle class) in relation to their body fat. A total of 1,222 subjects, selected by stratified random sampling were screened: 39 reported diabetic or hypertensive. Of the remaining subjects 600 were randomly selected for further testing. This is a report 441 men studied (149 rural, 142 slums, 150 urban middle class). The mean age of these men was 38 y rural, 38 y urban slums, 41 y urban middle class, mean BMI 21.0 kg/m{sup 2}, 22.3 kg/m{sup 2} and 24.3 kg/m{sup 2} respectively, mean body fat percent by bio-impedance 20.4%, 22.5% and 30.4% and by Deuterated water was 19.9%, 21.6% and 27.2% respectively. A 75 g oral glucose tolerance test (WHO 1985) showed no diabetes in rural subjects, while 4% urban slum dwellers and 10 in urban middle class were diabetic; 9% rural men had IGT, compared to 12% in urban slums and 20% in urban middle class. Hypertension (blood pressure {>=} 140/90 mm Bg) was present in 2% rural men, 4% in urban slums and in 10% men in urban middle class. Mean plasma cholesterol concentration was  More>>
Authors:
Yajnik, C S; Lubree, H G; Rege, S S; Bhat, D S; Raut, K N; Panchanadikar, A S; Joglekar, C B; Naik, S S; [1]  Shetty, P; [2]  Yudkin, J; [3]  Kurpad, A V [4] 
  1. Diabetest Unit, KEM Hospital Resarch Centre, Pune (India)
  2. London School of Hygiene and Tropical Medicine, London (United Kingdom)
  3. International Health and Medical Education Centre, UCL, London (United Kingdom)
  4. St. John's Medical College, Bangalore (India)
Publication Date:
Jul 01, 2002
Product Type:
Conference
Report Number:
NAHRES-70
Resource Relation:
Conference: 2. research co-ordination meeting on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-insulin dependent diseases) in ageing, Kingston (Jamaica), 25-29 Jun 2001; Other Information: 5 tabs; PBD: 2002; Related Information: In: Co-ordinated research project on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-Insulin dependent diseases) in ageing. Report on the second research co-ordination meeting, 214 pages.
Subject:
60 APPLIED LIFE SCIENCES; AGED ADULTS; BODY; CHOLESTEROL; FATS; GLUCOSE; HYPERTENSION; INSULIN; ISOTOPE APPLICATIONS; MEN; METABOLIC DISEASES; MULTIVARIATE ANALYSIS; NUTRITION; NUTRITIONAL DEFICIENCY
OSTI ID:
20487946
Research Organizations:
International Atomic Energy Agency, Section of Nutritional and Health-Related Environmental Studies, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0404147061044
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 99-104
Announcement Date:

Citation Formats

Yajnik, C S, Lubree, H G, Rege, S S, Bhat, D S, Raut, K N, Panchanadikar, A S, Joglekar, C B, Naik, S S, Shetty, P, Yudkin, J, and Kurpad, A V. Total body fat, proinflammatory cytokines and insulin resistance in Indian subjects. IAEA: N. p., 2002. Web.
Yajnik, C S, Lubree, H G, Rege, S S, Bhat, D S, Raut, K N, Panchanadikar, A S, Joglekar, C B, Naik, S S, Shetty, P, Yudkin, J, & Kurpad, A V. Total body fat, proinflammatory cytokines and insulin resistance in Indian subjects. IAEA.
Yajnik, C S, Lubree, H G, Rege, S S, Bhat, D S, Raut, K N, Panchanadikar, A S, Joglekar, C B, Naik, S S, Shetty, P, Yudkin, J, and Kurpad, A V. 2002. "Total body fat, proinflammatory cytokines and insulin resistance in Indian subjects." IAEA.
@misc{etde_20487946,
title = {Total body fat, proinflammatory cytokines and insulin resistance in Indian subjects}
author = {Yajnik, C S, Lubree, H G, Rege, S S, Bhat, D S, Raut, K N, Panchanadikar, A S, Joglekar, C B, Naik, S S, Shetty, P, Yudkin, J, and Kurpad, A V}
abstractNote = {We studied cardiovascular risk factors in 30 to 50 year old Indian men in three geographical locations (rural, urban slums and urban middle class) in relation to their body fat. A total of 1,222 subjects, selected by stratified random sampling were screened: 39 reported diabetic or hypertensive. Of the remaining subjects 600 were randomly selected for further testing. This is a report 441 men studied (149 rural, 142 slums, 150 urban middle class). The mean age of these men was 38 y rural, 38 y urban slums, 41 y urban middle class, mean BMI 21.0 kg/m{sup 2}, 22.3 kg/m{sup 2} and 24.3 kg/m{sup 2} respectively, mean body fat percent by bio-impedance 20.4%, 22.5% and 30.4% and by Deuterated water was 19.9%, 21.6% and 27.2% respectively. A 75 g oral glucose tolerance test (WHO 1985) showed no diabetes in rural subjects, while 4% urban slum dwellers and 10 in urban middle class were diabetic; 9% rural men had IGT, compared to 12% in urban slums and 20% in urban middle class. Hypertension (blood pressure {>=} 140/90 mm Bg) was present in 2% rural men, 4% in urban slums and in 10% men in urban middle class. Mean plasma cholesterol concentration was 148 mg% in rural, 53 mg% in urban slums and 64 mg% in urban middle class, mean plasma triglyceride concentrations were 82 mg%, 95 mg% and 108 mg% respectively. All cardiovascular risk factors were strongly related to measures of obesity (body fat % and waist hip ratio). On multivariate analysis 2h plasma glucose (OGTT) concentration and blood pressure were additionally related to geographical location (urban middle class>slums>rural). Our results suggest that urbanisation increases the risk of glucose intolerance and hypertension independent of the body fat percent or its central distribution. This suggests there may he additional environmental factors in the urban environment increasing the risk of diabetes over and above the effect of body fat. (author)}
place = {IAEA}
year = {2002}
month = {Jul}
}