This report summarized briefly the research activities and achievements in the Institute for fiscal year 1993 (from April 1993 through March 1994). At the end of this period, the construction of HIMAC has been completed and preparatory experiments of physical and biological studies necessary to the clinical trial have started by use of the heavy ion beams of HIMAC itself. The Institute is covering a wide range of comprehensive radiological sciences from molecular biology to environmental studies and medicine including engineering for heavy ion therapy of cancer. Therefore, the topics collected in the main part have been classified into five categories (physics, chemistry, bio-medical sciences, clinical research and environmental sciences). (J.P.N.).