Abstract
Purpose: To evaluate the feasibility and efficacy of a concomitant partial bladder boost schedule in radiotherapy for invasive bladder cancer, coupling a limited boost volume with shortening of the overall treatment time. Methods and materials: Between 1994 and 1999, 50 patients with a T2-T4 N0M0 transitional cell carcinoma of the bladder received radiotherapy delivered in a short overall treatment time with a concomitant boost technique. With this technique a dose of 40 Gy in 2-Gy fractions was administered to the small pelvis with a concomitant boost limited to the bladder tumor area plus margin of 15 Gy in fractions of 0.75 Gy. The total tumor dose was 55 Gy in 20 fractions in 4 weeks. Toxicity was scored according to EORTC/RTOG toxicity criteria. Results: The feasibility of the treatment was good. Severe acute toxicity {>=}G3 was observed in seven patients (14%). Severe late toxicity {>=}G3 was observed in six patients (13%). Thirty-seven patients (74%) showed a complete and five (10 %) a partial remission after treatment. The actuarial 3-year freedom of local progression was 55%. Conclusion: In external radiotherapy for muscle invasive bladder cancer a concomitant boost technique coupling a partial bladder boost with shortening of the overall treatment time
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Citation Formats
Pos, Floris J, Tienhoven, Geertjan van, Hulshof, Maarten C.C.M., Koedooder, Kees, and Gonzalez Gonzalez, Dionisio.
Concomitant boost radiotherapy for muscle invasive bladder cancer.
Ireland: N. p.,
2003.
Web.
doi:10.1016/S0167-8140(03)00019-7.
Pos, Floris J, Tienhoven, Geertjan van, Hulshof, Maarten C.C.M., Koedooder, Kees, & Gonzalez Gonzalez, Dionisio.
Concomitant boost radiotherapy for muscle invasive bladder cancer.
Ireland.
https://doi.org/10.1016/S0167-8140(03)00019-7
Pos, Floris J, Tienhoven, Geertjan van, Hulshof, Maarten C.C.M., Koedooder, Kees, and Gonzalez Gonzalez, Dionisio.
2003.
"Concomitant boost radiotherapy for muscle invasive bladder cancer."
Ireland.
https://doi.org/10.1016/S0167-8140(03)00019-7.
@misc{etde_20444446,
title = {Concomitant boost radiotherapy for muscle invasive bladder cancer}
author = {Pos, Floris J, Tienhoven, Geertjan van, Hulshof, Maarten C.C.M., Koedooder, Kees, and Gonzalez Gonzalez, Dionisio}
abstractNote = {Purpose: To evaluate the feasibility and efficacy of a concomitant partial bladder boost schedule in radiotherapy for invasive bladder cancer, coupling a limited boost volume with shortening of the overall treatment time. Methods and materials: Between 1994 and 1999, 50 patients with a T2-T4 N0M0 transitional cell carcinoma of the bladder received radiotherapy delivered in a short overall treatment time with a concomitant boost technique. With this technique a dose of 40 Gy in 2-Gy fractions was administered to the small pelvis with a concomitant boost limited to the bladder tumor area plus margin of 15 Gy in fractions of 0.75 Gy. The total tumor dose was 55 Gy in 20 fractions in 4 weeks. Toxicity was scored according to EORTC/RTOG toxicity criteria. Results: The feasibility of the treatment was good. Severe acute toxicity {>=}G3 was observed in seven patients (14%). Severe late toxicity {>=}G3 was observed in six patients (13%). Thirty-seven patients (74%) showed a complete and five (10 %) a partial remission after treatment. The actuarial 3-year freedom of local progression was 55%. Conclusion: In external radiotherapy for muscle invasive bladder cancer a concomitant boost technique coupling a partial bladder boost with shortening of the overall treatment time provides a high probability of local control with acceptable toxicity.}
doi = {10.1016/S0167-8140(03)00019-7}
journal = []
issue = {1}
volume = {68}
journal type = {AC}
place = {Ireland}
year = {2003}
month = {Jul}
}
title = {Concomitant boost radiotherapy for muscle invasive bladder cancer}
author = {Pos, Floris J, Tienhoven, Geertjan van, Hulshof, Maarten C.C.M., Koedooder, Kees, and Gonzalez Gonzalez, Dionisio}
abstractNote = {Purpose: To evaluate the feasibility and efficacy of a concomitant partial bladder boost schedule in radiotherapy for invasive bladder cancer, coupling a limited boost volume with shortening of the overall treatment time. Methods and materials: Between 1994 and 1999, 50 patients with a T2-T4 N0M0 transitional cell carcinoma of the bladder received radiotherapy delivered in a short overall treatment time with a concomitant boost technique. With this technique a dose of 40 Gy in 2-Gy fractions was administered to the small pelvis with a concomitant boost limited to the bladder tumor area plus margin of 15 Gy in fractions of 0.75 Gy. The total tumor dose was 55 Gy in 20 fractions in 4 weeks. Toxicity was scored according to EORTC/RTOG toxicity criteria. Results: The feasibility of the treatment was good. Severe acute toxicity {>=}G3 was observed in seven patients (14%). Severe late toxicity {>=}G3 was observed in six patients (13%). Thirty-seven patients (74%) showed a complete and five (10 %) a partial remission after treatment. The actuarial 3-year freedom of local progression was 55%. Conclusion: In external radiotherapy for muscle invasive bladder cancer a concomitant boost technique coupling a partial bladder boost with shortening of the overall treatment time provides a high probability of local control with acceptable toxicity.}
doi = {10.1016/S0167-8140(03)00019-7}
journal = []
issue = {1}
volume = {68}
journal type = {AC}
place = {Ireland}
year = {2003}
month = {Jul}
}