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MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences

Abstract

Objective: To compare the magnetic resonance image contrasts due to ferritin and hemosiderin in the brain tissue among different pulse sequences. Materials and methods: Fourteen patients with cavernous hemangioma in the brain prospectively underwent MR imaging with T2*-weighted gradient-echo (GRE), T2-weighted conventional spin-echo (SE) and fast spin-echo (FSE) sequences. The relative contrast ratios (CRs) of the hypointense part of cavernous hemangioma, globus pallidus and putamen to the deep frontal white matter were measured on each pulse sequence and statistically analyzed using analysis of variance followed by paired t-test. Results: In the hypointense part of cavernous hemangioma, relative CRs were significantly lower on T2*-weighted GRE than on T2-weighted SE images (P=0.0001), and on T2-weighted SE than on T2-weighted FSE images (P=0.0001). In the globus pallidus, relative CRs were significantly lower on T2-weighted SE than on T2*-weighted GRE images (P=0.002), and on T2*-weighted GRE than on T2-weighted FSE images (P=0.0002). In the putamen, relative CRs were significantly lower on T2-weighted SE than on T2*-weighted GRE images (P=0.001), and there was no significant difference between CRs on T2-weighted FSE and T2*-weighted GRE images (P=0.90). Conclusion: Hemosiderin showed best image contrast on T2*-weighted GRE images but ferritin showed more prominent image contrast on T2-weighted  More>>
Publication Date:
Dec 01, 2003
Product Type:
Journal Article
Resource Relation:
Journal Name: European Journal of Radiology; Journal Volume: 48; Journal Issue: 3; Other Information: DOI: 10.1016/S0720-048X(03)00054-8; PII: S0720048X03000548; Copyright (c) 2003 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: Dec 2003
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTRAST MEDIA; IMAGE PROCESSING; NERVOUS SYSTEM DISEASES; NMR IMAGING
OSTI ID:
20438628
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0720-048X; EJRADR; TRN: NL04R0026019136
Submitting Site:
NLN
Size:
page(s) 230-236
Announcement Date:

Citation Formats

Haque, Tabassum Laz, Miki, Yukio, Kanagaki, Mitsunori, Takahashi, Takahiro, Yamamoto, Akira, Konishi, Junya, Nozaki, Kazuhiko, Hashimoto, Nobuo, and Konishi, Junji. MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences. Netherlands: N. p., 2003. Web. doi:10.1016/S0720-048X(03)00054-8.
Haque, Tabassum Laz, Miki, Yukio, Kanagaki, Mitsunori, Takahashi, Takahiro, Yamamoto, Akira, Konishi, Junya, Nozaki, Kazuhiko, Hashimoto, Nobuo, & Konishi, Junji. MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences. Netherlands. doi:10.1016/S0720-048X(03)00054-8.
Haque, Tabassum Laz, Miki, Yukio, Kanagaki, Mitsunori, Takahashi, Takahiro, Yamamoto, Akira, Konishi, Junya, Nozaki, Kazuhiko, Hashimoto, Nobuo, and Konishi, Junji. 2003. "MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences." Netherlands. doi:10.1016/S0720-048X(03)00054-8. https://www.osti.gov/servlets/purl/10.1016/S0720-048X(03)00054-8.
@misc{etde_20438628,
title = {MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences}
author = {Haque, Tabassum Laz, Miki, Yukio, Kanagaki, Mitsunori, Takahashi, Takahiro, Yamamoto, Akira, Konishi, Junya, Nozaki, Kazuhiko, Hashimoto, Nobuo, and Konishi, Junji}
abstractNote = {Objective: To compare the magnetic resonance image contrasts due to ferritin and hemosiderin in the brain tissue among different pulse sequences. Materials and methods: Fourteen patients with cavernous hemangioma in the brain prospectively underwent MR imaging with T2*-weighted gradient-echo (GRE), T2-weighted conventional spin-echo (SE) and fast spin-echo (FSE) sequences. The relative contrast ratios (CRs) of the hypointense part of cavernous hemangioma, globus pallidus and putamen to the deep frontal white matter were measured on each pulse sequence and statistically analyzed using analysis of variance followed by paired t-test. Results: In the hypointense part of cavernous hemangioma, relative CRs were significantly lower on T2*-weighted GRE than on T2-weighted SE images (P=0.0001), and on T2-weighted SE than on T2-weighted FSE images (P=0.0001). In the globus pallidus, relative CRs were significantly lower on T2-weighted SE than on T2*-weighted GRE images (P=0.002), and on T2*-weighted GRE than on T2-weighted FSE images (P=0.0002). In the putamen, relative CRs were significantly lower on T2-weighted SE than on T2*-weighted GRE images (P=0.001), and there was no significant difference between CRs on T2-weighted FSE and T2*-weighted GRE images (P=0.90). Conclusion: Hemosiderin showed best image contrast on T2*-weighted GRE images but ferritin showed more prominent image contrast on T2-weighted SE than on T2*-weighted GRE images, which may help to determine an appropriate pulse sequence in neurological diseases associated with excessive ferritin accumulation.}
doi = {10.1016/S0720-048X(03)00054-8}
journal = {European Journal of Radiology}
issue = {3}
volume = {48}
journal type = {AC}
place = {Netherlands}
year = {2003}
month = {Dec}
}