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{sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea

Conference:

Abstract

Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate {sup 166}Ho-Hydroxyapatite ({sup 166} Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: {sup 166}Holmiun was produced by irradiation of Ho{sub 2}O{sub 3} at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the {sup 166}Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using {sup 67}Ga citrate before and after {sup 166} Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The {sup 166} Ho-HA distribution and localization was monitored using gamma camera images taken  More>>
Authors:
Chandia, M; Errazu, X; [1]  Mendoza, P; [2]  Troncoso, F; [1]  Jofre, J; Sierralta, P [2] 
  1. Comision Chilena de Energia Nuclear, Santiago (Chile)
  2. Departamento de Medicina Nuclear, Hospital Militar, Santiago (Chile)
Publication Date:
Jan 01, 2003
Product Type:
Conference
Resource Relation:
Conference: 3. Scientific meeting of Chilean Nuclear Energy Commission, III Jornadas cientificas de la Comision Chilena de Energia Nuclear, Santiago (Chile), 13-17 Jan 2003; Other Information: PBD: Jan 2003; Related Information: In: III Scientific meeting of Chilean Nuclear Energy Commission. Abstracts, III Jornadas cientificas de la Comision Chilena de Energia Nuclear. Resumenes, 60 pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHILE; EVALUATION; HOLMIUM 166; LA REINA RECH-1 REACTOR; RHEUMATIC DISEASES; SCINTISCANNING; THERAPEUTIC USES; USES
OSTI ID:
20412934
Research Organizations:
Comision Chilena de Energia Nuclear (CCHEN), Santiago (Chile)
Country of Origin:
Chile
Language:
Spanish
Other Identifying Numbers:
TRN: CL03C0378086583
Availability:
Available from Library of CCHEN
Submitting Site:
INIS
Size:
page(s) 14
Announcement Date:

Conference:

Citation Formats

Chandia, M, Errazu, X, Mendoza, P, Troncoso, F, Jofre, J, and Sierralta, P. {sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea. Chile: N. p., 2003. Web.
Chandia, M, Errazu, X, Mendoza, P, Troncoso, F, Jofre, J, & Sierralta, P. {sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea. Chile.
Chandia, M, Errazu, X, Mendoza, P, Troncoso, F, Jofre, J, and Sierralta, P. 2003. "{sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea." Chile.
@misc{etde_20412934,
title = {{sup 166} Ho-HA Evaluation as therapeutic agent for rheumatoid arthritis treatment; Evaluacion de {sup 166}Ho-Ha como agente terapeutico en el tratamiento de la artritis reumatoidea}
author = {Chandia, M, Errazu, X, Mendoza, P, Troncoso, F, Jofre, J, and Sierralta, P}
abstractNote = {Aim: Rheumatoid arthritis is a limiting disease having, among its pathological features, the inflammation of synovial tissue with progressive and later destruction of the articulation. This lead to joint deformation and loss of its function, generating pain and reducing the mobility of the affected articulation. The aim was to evaluate {sup 166}Ho-Hydroxyapatite ({sup 166} Ho-HA) as potential radiopharmaceutical for the syntomatic treatment of chronic and acute arthritis Materials and Methods: {sup 166}Holmiun was produced by irradiation of Ho{sub 2}O{sub 3} at La Reina Research Reactor, Nuclear Chilean Energy Commission. Hydroxyapatite was in-house synthetized. Its labelling and quality controls follows the internationally accepted procedures. An antigen arthritis was induced to eight New Zealand rabbits with the {sup 166}Ho-HA radiochemical being administred thereafter in two dosage modalities (single and double). The compound therapeutic efficiency was evaluated based upon clinical improvement and images from the inflamated articulation using {sup 67}Ga citrate before and after {sup 166} Ho-HA injection. Results: The radiochemical purity of the innoculated compound was greater than 98% as measured under sterility conditions. Clinically, an inflamation reduction (2 cm), appetite improvement and general well being was observed. The {sup 166} Ho-HA distribution and localization was monitored using gamma camera images taken at 4 and 24 h. There was no evidence of extraarticular leakage. From the {sup 67}Ga citrate imaging, the acute group shows an overall improvement of well being corresponding to a lesser uptake at the inflamated articulation, regarding to the chronic group. The {sup 166}Ho-HA double dosis, compared to the single dosis, suggest a reduced uptake of {sup 67}Ga citrate at the inflamated tissue, meaning an increased therapeutic effect. Conclusions: {sup 166} Ho-HA is usefull as therapeutic agent for the syntomatic treatment of rheumatoideal arthritis as shown by imaging and clinical examination (author)}
place = {Chile}
year = {2003}
month = {Jan}
}