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FDG F18/Rest Tl 201 SPECT patterns in recent myocardial infarction. Predictive value for regional function recovery

Journal Article:

Abstract

Background: detecting viability is important after recent myocardial infarction (MI). SPECT FDG/Tl flow-metabolism patterns for predicting functional recovery were analyzed in this setting. Method: forty-one patients were studied (56+-12 years; 80% males) with Tl 201 at rest and FDG F 18 SPECT at a mean of 8.9 days post MI (range:1-24). All had baseline and 3 month follow-up echocardiography (Echo) and initial coronary angiography. They were submitted to primary PTCA in 12 cases, late PTCA in 15 and bypass surgery in 10 and thrombolysis was performed in 4 patients as only procedure. A total of 345 culprit artery territory segments were interpreted by 3 nuclear independent observers. Analysis included segments with or without abnormal motion. Results: FDG/Tl 201 on patient basis, had: sensitivity 91%; specificity 56%; positive predictive value 88 %; negative predictive value (NPV) 63% and accuracy 83%. The analysis of segments with abnormal contractility showed values of 67%, 69%, 44%, 85% and 68%, respectively. Reverse mismatch with FDG/Tl appears to predict viability similarly to classical mismatch; severe or moderate match was highly associated with no functional recovery (NPV 85%). Conclusion: flow-perfusion patterns are variable in recent MI. FDG/Tl 201 SPECT has acceptable accuracy for predicting functional recovery and  More>>
Authors:
Massardo, Teresa; [1]  Gonzalez, Patricio; Coll, Claudia; Yovanovich, Jorge; Jofre, M Josefina; Humeres, Pamela; Sierralta, Paulina; Chamorro, Hernan; Ramirez, Alfredo; Kunstmann, Sonia; Lopez, Hector; Aramburu, Ivonne; Bru, Solange; [2]  Clinica Santa Maria, Santiago [3] 
  1. Universidad de Chile, Hospital Clinico. Centro de Medicina Nuclear, Santiago (Chile)
  2. Universidad de Chile, Santiago (Chile). Hospital Clinico. Centros de Medicina Nuclear e Cardiovascular
  3. Chile
Publication Date:
Apr 01, 2003
Product Type:
Journal Article
Resource Relation:
Journal Name: Alasbimn Journal; Journal Volume: 5; Journal Issue: 20; Other Information: 37 refs., 1 fig., 2 tabs; PBD: Apr 2003
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL RECOVERY; BIOMEDICAL RADIOGRAPHY; BLOOD FLOW; CORONARIES; DYNAMIC FUNCTION STUDIES; FLUORINE 18; FLUORODEOXYGLUCOSE; MYOCARDIAL INFARCTION; PATIENTS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SURGERY; THALLIUM 201
OSTI ID:
20412914
Country of Origin:
Chile
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0717-4055; TRN: CL03C0358086563
Availability:
Available as electronic journal from the website: http://www2.alasbimnjournal.cl/alasbimn/CDA/sec_b/0,1206,SCID%253D3888,00.html;INIS
Submitting Site:
INIS
Size:
12 pages
Announcement Date:

Journal Article:

Citation Formats

Massardo, Teresa, Gonzalez, Patricio, Coll, Claudia, Yovanovich, Jorge, Jofre, M Josefina, Humeres, Pamela, Sierralta, Paulina, Chamorro, Hernan, Ramirez, Alfredo, Kunstmann, Sonia, Lopez, Hector, Aramburu, Ivonne, Bru, Solange, and Clinica Santa Maria, Santiago. FDG F18/Rest Tl 201 SPECT patterns in recent myocardial infarction. Predictive value for regional function recovery. Chile: N. p., 2003. Web.
Massardo, Teresa, Gonzalez, Patricio, Coll, Claudia, Yovanovich, Jorge, Jofre, M Josefina, Humeres, Pamela, Sierralta, Paulina, Chamorro, Hernan, Ramirez, Alfredo, Kunstmann, Sonia, Lopez, Hector, Aramburu, Ivonne, Bru, Solange, & Clinica Santa Maria, Santiago. FDG F18/Rest Tl 201 SPECT patterns in recent myocardial infarction. Predictive value for regional function recovery. Chile.
Massardo, Teresa, Gonzalez, Patricio, Coll, Claudia, Yovanovich, Jorge, Jofre, M Josefina, Humeres, Pamela, Sierralta, Paulina, Chamorro, Hernan, Ramirez, Alfredo, Kunstmann, Sonia, Lopez, Hector, Aramburu, Ivonne, Bru, Solange, and Clinica Santa Maria, Santiago. 2003. "FDG F18/Rest Tl 201 SPECT patterns in recent myocardial infarction. Predictive value for regional function recovery." Chile.
@misc{etde_20412914,
title = {FDG F18/Rest Tl 201 SPECT patterns in recent myocardial infarction. Predictive value for regional function recovery}
author = {Massardo, Teresa, Gonzalez, Patricio, Coll, Claudia, Yovanovich, Jorge, Jofre, M Josefina, Humeres, Pamela, Sierralta, Paulina, Chamorro, Hernan, Ramirez, Alfredo, Kunstmann, Sonia, Lopez, Hector, Aramburu, Ivonne, Bru, Solange, and Clinica Santa Maria, Santiago}
abstractNote = {Background: detecting viability is important after recent myocardial infarction (MI). SPECT FDG/Tl flow-metabolism patterns for predicting functional recovery were analyzed in this setting. Method: forty-one patients were studied (56+-12 years; 80% males) with Tl 201 at rest and FDG F 18 SPECT at a mean of 8.9 days post MI (range:1-24). All had baseline and 3 month follow-up echocardiography (Echo) and initial coronary angiography. They were submitted to primary PTCA in 12 cases, late PTCA in 15 and bypass surgery in 10 and thrombolysis was performed in 4 patients as only procedure. A total of 345 culprit artery territory segments were interpreted by 3 nuclear independent observers. Analysis included segments with or without abnormal motion. Results: FDG/Tl 201 on patient basis, had: sensitivity 91%; specificity 56%; positive predictive value 88 %; negative predictive value (NPV) 63% and accuracy 83%. The analysis of segments with abnormal contractility showed values of 67%, 69%, 44%, 85% and 68%, respectively. Reverse mismatch with FDG/Tl appears to predict viability similarly to classical mismatch; severe or moderate match was highly associated with no functional recovery (NPV 85%). Conclusion: flow-perfusion patterns are variable in recent MI. FDG/Tl 201 SPECT has acceptable accuracy for predicting functional recovery and excellent NPV to further exclude viability (author)}
journal = {Alasbimn Journal}
issue = {20}
volume = {5}
journal type = {AC}
place = {Chile}
year = {2003}
month = {Apr}
}