Abstract
Repeated administration of methamphetamine (MAP) causes behavioral sensitization in animals. We previously reported that the maximum accumulation level of [{sup 11}C]MAP in the MAP-sensitized dog brain was 1.4 times higher than that in the control. In behavioral studies, haloperidol (a dopamine D{sub 2} receptor antagonist) prevents MAP-induced behavioral sensitization, and cocaine (a dopamine reuptake blocker) has the cross-behavioral sensitization with MAP. In the present study, to elucidate the relation between the MAP-induced behavioral sensitization and the pharmacokinetics of MAP, we investigated the effects of haloperidol and cocaine pretreatments on brain regional distribution and kinetics of [{sup 11}C]MAP using positron emission tomography (PET). A significant increase of [{sup 11}C]MAP uptake into the sensitized dog brain was prevented by haloperidol and cocaine pretreatments. These pharmacokinetic changes were not due to the changes in the rate of MAP metabolism. These results suggest haloperidol and cocaine can change the cerebral pharmacokinetic profile of MAP in the behavioral-sensitized dog. The variations of MAP-accumulation may affect the development or expression of MAP-induced behavioral sensitization.
Citation Formats
Nakamura, Hitoshi, Hishinuma, Takanori, Tomioka, Yoshihisa, Ishiwata, Shunji, Ido, Tatsuo, Iwata, Ren, Funaki, Yoshihito, Itoh, Masatoshi, Fujiwara, Takehiko, Yanai, Kazuhiko, Sato, Mitsumoto, Numachi, Yohtaro, Yoshida, Sumiko, and Mizugaki, Michinao.
Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [{sup 11}C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study.
United Kingdom: N. p.,
1997.
Web.
doi:10.1016/S0969-8051(96)00204-1.
Nakamura, Hitoshi, Hishinuma, Takanori, Tomioka, Yoshihisa, Ishiwata, Shunji, Ido, Tatsuo, Iwata, Ren, Funaki, Yoshihito, Itoh, Masatoshi, Fujiwara, Takehiko, Yanai, Kazuhiko, Sato, Mitsumoto, Numachi, Yohtaro, Yoshida, Sumiko, & Mizugaki, Michinao.
Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [{sup 11}C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study.
United Kingdom.
https://doi.org/10.1016/S0969-8051(96)00204-1
Nakamura, Hitoshi, Hishinuma, Takanori, Tomioka, Yoshihisa, Ishiwata, Shunji, Ido, Tatsuo, Iwata, Ren, Funaki, Yoshihito, Itoh, Masatoshi, Fujiwara, Takehiko, Yanai, Kazuhiko, Sato, Mitsumoto, Numachi, Yohtaro, Yoshida, Sumiko, and Mizugaki, Michinao.
1997.
"Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [{sup 11}C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study."
United Kingdom.
https://doi.org/10.1016/S0969-8051(96)00204-1.
@misc{etde_20406128,
title = {Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [{sup 11}C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study}
author = {Nakamura, Hitoshi, Hishinuma, Takanori, Tomioka, Yoshihisa, Ishiwata, Shunji, Ido, Tatsuo, Iwata, Ren, Funaki, Yoshihito, Itoh, Masatoshi, Fujiwara, Takehiko, Yanai, Kazuhiko, Sato, Mitsumoto, Numachi, Yohtaro, Yoshida, Sumiko, and Mizugaki, Michinao}
abstractNote = {Repeated administration of methamphetamine (MAP) causes behavioral sensitization in animals. We previously reported that the maximum accumulation level of [{sup 11}C]MAP in the MAP-sensitized dog brain was 1.4 times higher than that in the control. In behavioral studies, haloperidol (a dopamine D{sub 2} receptor antagonist) prevents MAP-induced behavioral sensitization, and cocaine (a dopamine reuptake blocker) has the cross-behavioral sensitization with MAP. In the present study, to elucidate the relation between the MAP-induced behavioral sensitization and the pharmacokinetics of MAP, we investigated the effects of haloperidol and cocaine pretreatments on brain regional distribution and kinetics of [{sup 11}C]MAP using positron emission tomography (PET). A significant increase of [{sup 11}C]MAP uptake into the sensitized dog brain was prevented by haloperidol and cocaine pretreatments. These pharmacokinetic changes were not due to the changes in the rate of MAP metabolism. These results suggest haloperidol and cocaine can change the cerebral pharmacokinetic profile of MAP in the behavioral-sensitized dog. The variations of MAP-accumulation may affect the development or expression of MAP-induced behavioral sensitization.}
doi = {10.1016/S0969-8051(96)00204-1}
journal = []
issue = {2}
volume = {24}
journal type = {AC}
place = {United Kingdom}
year = {1997}
month = {Feb}
}
title = {Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [{sup 11}C]methamphetamine in methamphetamine sensitized dog: Application of PET to drug pharmacokinetic study}
author = {Nakamura, Hitoshi, Hishinuma, Takanori, Tomioka, Yoshihisa, Ishiwata, Shunji, Ido, Tatsuo, Iwata, Ren, Funaki, Yoshihito, Itoh, Masatoshi, Fujiwara, Takehiko, Yanai, Kazuhiko, Sato, Mitsumoto, Numachi, Yohtaro, Yoshida, Sumiko, and Mizugaki, Michinao}
abstractNote = {Repeated administration of methamphetamine (MAP) causes behavioral sensitization in animals. We previously reported that the maximum accumulation level of [{sup 11}C]MAP in the MAP-sensitized dog brain was 1.4 times higher than that in the control. In behavioral studies, haloperidol (a dopamine D{sub 2} receptor antagonist) prevents MAP-induced behavioral sensitization, and cocaine (a dopamine reuptake blocker) has the cross-behavioral sensitization with MAP. In the present study, to elucidate the relation between the MAP-induced behavioral sensitization and the pharmacokinetics of MAP, we investigated the effects of haloperidol and cocaine pretreatments on brain regional distribution and kinetics of [{sup 11}C]MAP using positron emission tomography (PET). A significant increase of [{sup 11}C]MAP uptake into the sensitized dog brain was prevented by haloperidol and cocaine pretreatments. These pharmacokinetic changes were not due to the changes in the rate of MAP metabolism. These results suggest haloperidol and cocaine can change the cerebral pharmacokinetic profile of MAP in the behavioral-sensitized dog. The variations of MAP-accumulation may affect the development or expression of MAP-induced behavioral sensitization.}
doi = {10.1016/S0969-8051(96)00204-1}
journal = []
issue = {2}
volume = {24}
journal type = {AC}
place = {United Kingdom}
year = {1997}
month = {Feb}
}