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Evaluation of renal function following administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP) in animals submitted to oral intoxication with uranyl nitrate; Evaluacion de la funcion renal luego de la administracion de etidronato bisodico en animales intoxicados con nitrato de uranilo por via oral

Abstract

Workers involved in the processes of extraction, purification and manufacture of uranium of nuclear plants are occupationally exposed to both natural and enriched uranium. Several chelating agents (TIRON, EDTA, BAI, etc.) have been tested in terms of their capacity to sequester uranium before it reaches its target organs. Our laboratory has studied a first generation biphosphonate, ethane-1-hydroxy-1,1-biphosphonate (EHBP). We have shown that treatment with EHBP induces survival rates of 75% and 100% in adult and suckling rats respectively intoxicated with an intraperitoneal injection of uranyl nitrate. There are no data available to date on the renal function following treatment with EBHP to counteract the toxic effects of an oral lethal dose of uranyl nitrate. The aim of the present study was to assay creatininemia and uremia as end-points to assess renal function. The results obtained reveal that the alterations in renal function induced by oral uranyl nitrate intoxication can be reduced at 48 hours and reverted at 14 days by subcutaneous or oral administration of EHBP. (author)
Authors:
Martinez, A B; Mandalunis, P M; Bozal, C B; Cabrini, Romulo L; Ubios, A M [1] 
  1. Comision Nacional de Energia Atomica, General San Martin (Argentina). Dept. de Radiobiologia
Publication Date:
Jul 01, 2003
Product Type:
Conference
Report Number:
INIS-AR-C-306
Resource Relation:
Conference: AATN 2001: 28. Annual meeting of the Argentine Association of Nuclear Technology, AATN 2001: 28. Reunion anual de la Asociacion Argentina de Tecnologia Nuclear (AATN), Buenos Aires (Argentina), 14-16 Nov 2001; Other Information: PBD: 2003
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; CHRONIC EXPOSURE; TOXIC MATERIALS; TOXICITY; URANIUM; URANYL NITRATES
OSTI ID:
20403326
Country of Origin:
Argentina
Language:
Spanish
Other Identifying Numbers:
TRN: AR03C0050077939
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
2 pages
Announcement Date:

Citation Formats

Martinez, A B, Mandalunis, P M, Bozal, C B, Cabrini, Romulo L, and Ubios, A M. Evaluation of renal function following administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP) in animals submitted to oral intoxication with uranyl nitrate; Evaluacion de la funcion renal luego de la administracion de etidronato bisodico en animales intoxicados con nitrato de uranilo por via oral. Argentina: N. p., 2003. Web.
Martinez, A B, Mandalunis, P M, Bozal, C B, Cabrini, Romulo L, & Ubios, A M. Evaluation of renal function following administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP) in animals submitted to oral intoxication with uranyl nitrate; Evaluacion de la funcion renal luego de la administracion de etidronato bisodico en animales intoxicados con nitrato de uranilo por via oral. Argentina.
Martinez, A B, Mandalunis, P M, Bozal, C B, Cabrini, Romulo L, and Ubios, A M. 2003. "Evaluation of renal function following administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP) in animals submitted to oral intoxication with uranyl nitrate; Evaluacion de la funcion renal luego de la administracion de etidronato bisodico en animales intoxicados con nitrato de uranilo por via oral." Argentina.
@misc{etde_20403326,
title = {Evaluation of renal function following administration of ethane-1-hydroxy-1,1-biphosphonate (EHBP) in animals submitted to oral intoxication with uranyl nitrate; Evaluacion de la funcion renal luego de la administracion de etidronato bisodico en animales intoxicados con nitrato de uranilo por via oral}
author = {Martinez, A B, Mandalunis, P M, Bozal, C B, Cabrini, Romulo L, and Ubios, A M}
abstractNote = {Workers involved in the processes of extraction, purification and manufacture of uranium of nuclear plants are occupationally exposed to both natural and enriched uranium. Several chelating agents (TIRON, EDTA, BAI, etc.) have been tested in terms of their capacity to sequester uranium before it reaches its target organs. Our laboratory has studied a first generation biphosphonate, ethane-1-hydroxy-1,1-biphosphonate (EHBP). We have shown that treatment with EHBP induces survival rates of 75% and 100% in adult and suckling rats respectively intoxicated with an intraperitoneal injection of uranyl nitrate. There are no data available to date on the renal function following treatment with EBHP to counteract the toxic effects of an oral lethal dose of uranyl nitrate. The aim of the present study was to assay creatininemia and uremia as end-points to assess renal function. The results obtained reveal that the alterations in renal function induced by oral uranyl nitrate intoxication can be reduced at 48 hours and reverted at 14 days by subcutaneous or oral administration of EHBP. (author)}
place = {Argentina}
year = {2003}
month = {Jul}
}