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Base of skull and cervical spine chordomas in children treated by high-dose irradiation

Abstract

Purpose: To evaluate the outcome of children with base of skull or cervical spine chordomas treated by high dose irradiation. Methods and Materials: Eighteen children, 4 to 18 years of age, with base of skull or cervical spine chordomas, received fractionated high-dose postoperative radiation using mixed photon and 160 MeV proton beams. The median tumor dose was 69 Cobalt Gray-equivalent (CGE) with a 1.8 CGE daily fraction. Results: The median follow-up was 72 months. The 5-year actuarial survival was 68% and the 5-year disease-free survival (DFS) was 63%. The only significant prognostic factor was the location: patients with cervical spine chordomas had a worse survival than those with base of skull lesions (p = 0.008). The incidence of treatment-related morbidity was acceptable: two patients developed a growth hormone deficit corrected by hormone replacement, one temporal lobe necrosis, and one fibrosis of the temporalis muscle, improved by surgery. Conclusion: Chordomas in children behave similarly to those in adults: children can receive the same high-dose irradiation as adults with acceptable morbidity.
Publication Date:
Feb 01, 1995
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 31; Journal Issue: 3; Other Information: Copyright (c) 1995 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 1 Feb 1995
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHILDREN; FRACTIONATED IRRADIATION; MEV RANGE 100-1000; NEOPLASMS; PHOTON BEAMS; PROTON BEAMS; RADIOTHERAPY; SKELETAL DISEASES; SKULL; SPINAL CORD; SURGERY; SURVIVAL TIME
OSTI ID:
20391060
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US03R1447057407
Submitting Site:
INIS
Size:
page(s) 577-581
Announcement Date:
Nov 20, 2003

Citation Formats

Benk, Veronique, Liebsch, Norbert J, Munzenrider, John E, Efird, John, McManus, Patricia, and Suit, Herman. Base of skull and cervical spine chordomas in children treated by high-dose irradiation. United States: N. p., 1995. Web. doi:10.1016/0360-3016(94)00395-2.
Benk, Veronique, Liebsch, Norbert J, Munzenrider, John E, Efird, John, McManus, Patricia, & Suit, Herman. Base of skull and cervical spine chordomas in children treated by high-dose irradiation. United States. doi:10.1016/0360-3016(94)00395-2.
Benk, Veronique, Liebsch, Norbert J, Munzenrider, John E, Efird, John, McManus, Patricia, and Suit, Herman. 1995. "Base of skull and cervical spine chordomas in children treated by high-dose irradiation." United States. doi:10.1016/0360-3016(94)00395-2. https://www.osti.gov/servlets/purl/10.1016/0360-3016(94)00395-2.
@misc{etde_20391060,
title = {Base of skull and cervical spine chordomas in children treated by high-dose irradiation}
author = {Benk, Veronique, Liebsch, Norbert J, Munzenrider, John E, Efird, John, McManus, Patricia, and Suit, Herman}
abstractNote = {Purpose: To evaluate the outcome of children with base of skull or cervical spine chordomas treated by high dose irradiation. Methods and Materials: Eighteen children, 4 to 18 years of age, with base of skull or cervical spine chordomas, received fractionated high-dose postoperative radiation using mixed photon and 160 MeV proton beams. The median tumor dose was 69 Cobalt Gray-equivalent (CGE) with a 1.8 CGE daily fraction. Results: The median follow-up was 72 months. The 5-year actuarial survival was 68% and the 5-year disease-free survival (DFS) was 63%. The only significant prognostic factor was the location: patients with cervical spine chordomas had a worse survival than those with base of skull lesions (p = 0.008). The incidence of treatment-related morbidity was acceptable: two patients developed a growth hormone deficit corrected by hormone replacement, one temporal lobe necrosis, and one fibrosis of the temporalis muscle, improved by surgery. Conclusion: Chordomas in children behave similarly to those in adults: children can receive the same high-dose irradiation as adults with acceptable morbidity.}
doi = {10.1016/0360-3016(94)00395-2}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {3}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Feb}
}