Abstract
Purpose: To determine the cause of death in children who survive more than 5 years after radiation treatment of a brain tumor. Methods and Material: Nine hundred and twelve consecutive children with a primary brain tumor irradiated at the Princess Margaret Hospital or Toronto-Bayview Regional Cancer Center from 1958 to 1991, were evaluated for long-term outcome. Results: Overall 10- and 20-year survival rates were 44% and 37%. Subsequent survival of 377 5-year survivors was, at an additional 10 and 20 years, 78% and 67%. Most (83%) deaths that occurred more than 5 years from diagnosis were a result of relapse of the original tumor. The 10-year survival rate subsequent to relapse was 9% when the first relapse occurred less than one year from diagnosis, 17% for 1-2 years, and 31% when the time to relapse was 3 years or greater. The cumulative actuarial incidence of, and death from, second malignant tumors at 30 years from diagnosis was 18% and 13%, respectively. Conclusions: Death later than 5 years from diagnosis of a brain tumor in children is common and is usually due to progressive disease in slowly evolving low grade tumors. Death from a second malignant tumor becomes more frequent than
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Citation Formats
Jenkin, Derek, Greenberg, Mark, Hoffman, Harold, Hendrick, Bruce, Humphreys, Robin, and Vatter, Annette.
Brain tumors in children: long-term survival after radiation treatment.
United States: N. p.,
1995.
Web.
doi:10.1016/0360-3016(94)00393-Y.
Jenkin, Derek, Greenberg, Mark, Hoffman, Harold, Hendrick, Bruce, Humphreys, Robin, & Vatter, Annette.
Brain tumors in children: long-term survival after radiation treatment.
United States.
doi:10.1016/0360-3016(94)00393-Y.
Jenkin, Derek, Greenberg, Mark, Hoffman, Harold, Hendrick, Bruce, Humphreys, Robin, and Vatter, Annette.
1995.
"Brain tumors in children: long-term survival after radiation treatment."
United States.
doi:10.1016/0360-3016(94)00393-Y.
https://www.osti.gov/servlets/purl/10.1016/0360-3016(94)00393-Y.
@misc{etde_20391042,
title = {Brain tumors in children: long-term survival after radiation treatment}
author = {Jenkin, Derek, Greenberg, Mark, Hoffman, Harold, Hendrick, Bruce, Humphreys, Robin, and Vatter, Annette}
abstractNote = {Purpose: To determine the cause of death in children who survive more than 5 years after radiation treatment of a brain tumor. Methods and Material: Nine hundred and twelve consecutive children with a primary brain tumor irradiated at the Princess Margaret Hospital or Toronto-Bayview Regional Cancer Center from 1958 to 1991, were evaluated for long-term outcome. Results: Overall 10- and 20-year survival rates were 44% and 37%. Subsequent survival of 377 5-year survivors was, at an additional 10 and 20 years, 78% and 67%. Most (83%) deaths that occurred more than 5 years from diagnosis were a result of relapse of the original tumor. The 10-year survival rate subsequent to relapse was 9% when the first relapse occurred less than one year from diagnosis, 17% for 1-2 years, and 31% when the time to relapse was 3 years or greater. The cumulative actuarial incidence of, and death from, second malignant tumors at 30 years from diagnosis was 18% and 13%, respectively. Conclusions: Death later than 5 years from diagnosis of a brain tumor in children is common and is usually due to progressive disease in slowly evolving low grade tumors. Death from a second malignant tumor becomes more frequent than death from the original tumor after 15 years from diagnosis.}
doi = {10.1016/0360-3016(94)00393-Y}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {3}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Feb}
}
title = {Brain tumors in children: long-term survival after radiation treatment}
author = {Jenkin, Derek, Greenberg, Mark, Hoffman, Harold, Hendrick, Bruce, Humphreys, Robin, and Vatter, Annette}
abstractNote = {Purpose: To determine the cause of death in children who survive more than 5 years after radiation treatment of a brain tumor. Methods and Material: Nine hundred and twelve consecutive children with a primary brain tumor irradiated at the Princess Margaret Hospital or Toronto-Bayview Regional Cancer Center from 1958 to 1991, were evaluated for long-term outcome. Results: Overall 10- and 20-year survival rates were 44% and 37%. Subsequent survival of 377 5-year survivors was, at an additional 10 and 20 years, 78% and 67%. Most (83%) deaths that occurred more than 5 years from diagnosis were a result of relapse of the original tumor. The 10-year survival rate subsequent to relapse was 9% when the first relapse occurred less than one year from diagnosis, 17% for 1-2 years, and 31% when the time to relapse was 3 years or greater. The cumulative actuarial incidence of, and death from, second malignant tumors at 30 years from diagnosis was 18% and 13%, respectively. Conclusions: Death later than 5 years from diagnosis of a brain tumor in children is common and is usually due to progressive disease in slowly evolving low grade tumors. Death from a second malignant tumor becomes more frequent than death from the original tumor after 15 years from diagnosis.}
doi = {10.1016/0360-3016(94)00393-Y}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {3}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Feb}
}