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Follow-up of cognitive functioning in patients with small cell lung cancer

Abstract

Purpose: Study of the course of possible treatment-related cognitive impairment in patients with small cell lung cancer. Methods and Materials: Thirty-two consecutive patients with small cell lung cancer underwent successive neurologic and neuropsychologic examinations until 5 months after prophylactic cranial irradiation, and in their pretherapeutic condition were compared to matched controls. Patients with brain metastases were excluded from this study. Results: Neurologic examination revealed central nervous system (CNS) abnormalities only in the 14 patients with brain metastases. In the remaining patients, neuropsychologic tests showed clear differences between the pretherapeutic performance of patients and that of matched controls (p < 0.001), but no significant deterioration either during or after therapy (0.1 < p < 0.8). Conclusion: The difference between the pretherapeutic performance of patients and that of matched controls may indicate disease-related cognitive impairment. Within the observation period, no adverse effects of the used therapy were found. Our observations underline the importance of a pretherapeutic assessment in neurotoxicity research.
Publication Date:
Feb 15, 1995
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 31; Journal Issue: 4; Other Information: PII: 0360301694005796; Copyright (c) 1995 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 15 Feb 1995
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; LUNGS; MEDICAL EXAMINATIONS; NEUROLOGY; PATIENTS; RADIOTHERAPY; RESPIRATORY TRACT CELLS
OSTI ID:
20391031
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US03R1481055976
Submitting Site:
INIS
Size:
page(s) 911-914
Announcement Date:

Citation Formats

Oosterhout, Ansel G.M. van, Boon, Peter J, Houx, Peter J, Velde, Guul P.M. ten, and Twijnstra, Albert. Follow-up of cognitive functioning in patients with small cell lung cancer. United States: N. p., 1995. Web. doi:10.1016/0360-3016(94)00579-6.
Oosterhout, Ansel G.M. van, Boon, Peter J, Houx, Peter J, Velde, Guul P.M. ten, & Twijnstra, Albert. Follow-up of cognitive functioning in patients with small cell lung cancer. United States. doi:10.1016/0360-3016(94)00579-6.
Oosterhout, Ansel G.M. van, Boon, Peter J, Houx, Peter J, Velde, Guul P.M. ten, and Twijnstra, Albert. 1995. "Follow-up of cognitive functioning in patients with small cell lung cancer." United States. doi:10.1016/0360-3016(94)00579-6. https://www.osti.gov/servlets/purl/10.1016/0360-3016(94)00579-6.
@misc{etde_20391031,
title = {Follow-up of cognitive functioning in patients with small cell lung cancer}
author = {Oosterhout, Ansel G.M. van, Boon, Peter J, Houx, Peter J, Velde, Guul P.M. ten, and Twijnstra, Albert}
abstractNote = {Purpose: Study of the course of possible treatment-related cognitive impairment in patients with small cell lung cancer. Methods and Materials: Thirty-two consecutive patients with small cell lung cancer underwent successive neurologic and neuropsychologic examinations until 5 months after prophylactic cranial irradiation, and in their pretherapeutic condition were compared to matched controls. Patients with brain metastases were excluded from this study. Results: Neurologic examination revealed central nervous system (CNS) abnormalities only in the 14 patients with brain metastases. In the remaining patients, neuropsychologic tests showed clear differences between the pretherapeutic performance of patients and that of matched controls (p < 0.001), but no significant deterioration either during or after therapy (0.1 < p < 0.8). Conclusion: The difference between the pretherapeutic performance of patients and that of matched controls may indicate disease-related cognitive impairment. Within the observation period, no adverse effects of the used therapy were found. Our observations underline the importance of a pretherapeutic assessment in neurotoxicity research.}
doi = {10.1016/0360-3016(94)00579-6}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {4}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Feb}
}