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Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes

Abstract

Purpose: To determine the effect of tamoxifen on local control after partial mastectomy with and without adjuvant breast irradiation. Methods and Materials: A retrospective study of 97 node positive patients identified from the records of the London Regional Cancer Center included 44 patients who received tamoxifen and breast irradiation (40 or 50 Gy plus booster dose) after partial mastectomy, and 53 patients who received tamoxifen only after partial mastectomy. Base line characteristics of the two groups were similar. Results: At 39 months actuarial follow-up there was a breast tumor recurrence (BTR) in 5% vs. 21% of patients when radiation was omitted (p = 0.0388), but there was no difference in the cause-specific mortality of the two treatment groups. Cox Regression analysis (on only 10 BTR) showed age and adjuvant radiation as significant predictors of BTR. In patients not receiving radiation, no BTR was seen in 22 patients {>=}70 years of age at diagnosis vs. 8 BTR in 31 patients <70 years (p = 0.0130). All BTR occurred while patients were receiving tamoxifen. Conclusion: Tamoxifen alone with omission of radiation after partial mastectomy provides inferior breast tumor control in node positive patients. This is especially true for patients under 70 years  More>>
Publication Date:
Feb 15, 1995
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 31; Journal Issue: 4; Other Information: PII: 0360301694004994; Copyright (c) 1995 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 15 Feb 1995
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AGE DEPENDENCE; CHEMOTHERAPY; COMBINED THERAPY; MAMMARY GLANDS; NEOPLASMS; RADIOTHERAPY; SURGERY; TAMOXIFEN
OSTI ID:
20391014
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US03R1464055959
Submitting Site:
INIS
Size:
page(s) 777-781
Announcement Date:
Nov 20, 2003

Citation Formats

Cooke, Andrew L, Perera, Francisco, Fisher, Barbara, Opeitum, Abiola, and Yu, Norman. Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes. United States: N. p., 1995. Web. doi:10.1016/0360-3016(94)00499-4.
Cooke, Andrew L, Perera, Francisco, Fisher, Barbara, Opeitum, Abiola, & Yu, Norman. Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes. United States. doi:10.1016/0360-3016(94)00499-4.
Cooke, Andrew L, Perera, Francisco, Fisher, Barbara, Opeitum, Abiola, and Yu, Norman. 1995. "Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes." United States. doi:10.1016/0360-3016(94)00499-4. https://www.osti.gov/servlets/purl/10.1016/0360-3016(94)00499-4.
@misc{etde_20391014,
title = {Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes}
author = {Cooke, Andrew L, Perera, Francisco, Fisher, Barbara, Opeitum, Abiola, and Yu, Norman}
abstractNote = {Purpose: To determine the effect of tamoxifen on local control after partial mastectomy with and without adjuvant breast irradiation. Methods and Materials: A retrospective study of 97 node positive patients identified from the records of the London Regional Cancer Center included 44 patients who received tamoxifen and breast irradiation (40 or 50 Gy plus booster dose) after partial mastectomy, and 53 patients who received tamoxifen only after partial mastectomy. Base line characteristics of the two groups were similar. Results: At 39 months actuarial follow-up there was a breast tumor recurrence (BTR) in 5% vs. 21% of patients when radiation was omitted (p = 0.0388), but there was no difference in the cause-specific mortality of the two treatment groups. Cox Regression analysis (on only 10 BTR) showed age and adjuvant radiation as significant predictors of BTR. In patients not receiving radiation, no BTR was seen in 22 patients {>=}70 years of age at diagnosis vs. 8 BTR in 31 patients <70 years (p = 0.0130). All BTR occurred while patients were receiving tamoxifen. Conclusion: Tamoxifen alone with omission of radiation after partial mastectomy provides inferior breast tumor control in node positive patients. This is especially true for patients under 70 years of age. Patients aged 70 years or older at the time of diagnosis of breast cancer who receive tamoxifen have a low rate of breast tumor recurrence when radiation is omitted. These patients represent a group for whom radiation might not be necessary.}
doi = {10.1016/0360-3016(94)00499-4}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {4}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Feb}
}