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Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care

Abstract

Purpose: Analysis of treatment outcome for Stage I-IIA supradiaphragmatic Hodgkin's disease treated solely by irradiation in Australia and New Zealand. Methods and Materials: Patients with supradiaphragmatic Hodgkin's disease only who were treated by irradiation alone with curative intent between 1969 to 1988 were retrospectively reviewed. Ten radiation oncology departments in Australia and New Zealand contributed patient data to the study. Patient, tumor, and treatment variables were recorded. Disease-free interval, survival, and complications were analyzed. Results: Eight hundred and twenty patients were reviewed. The median age was 29 years. There were 437 men and 383 women. The distribution of 310 clinically staged patients was 170 stage IA, 5 IB, and 135 IIA. Five hundred and ten patients received laparotomies, and pathologic staging was as follows: IA 214, IB 13, IIA 283. The 10-year acturial disease-free rate was 69% and overall survival rate was 79%. Increasing age, male sex, higher number of involved sites, the use of involved field irradiation, no staging laparotomy, and earlier year of treatment were significantly associated with an increased risk of relapse and lower survival. Actuarial 10-year survival following recurrence was 48%. Acute complications requiring interruption to treatment occurred in 46 patients (6%), but < 1% had  More>>
Publication Date:
Jan 15, 1995
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 31; Journal Issue: 2; Other Information: Copyright (c) 1995 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 15 Jan 1995
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AGE DEPENDENCE; AUSTRALIA; HODGKINS DISEASE; NEW ZEALAND; PATIENTS; RADIOTHERAPY; SURVIVAL CURVES
OSTI ID:
20390982
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US03R1404054837
Submitting Site:
INIS
Size:
page(s) 227-236
Announcement Date:

Citation Formats

Barton, Michael, Boyages, John, Crennan, Elizabeth, Davis, Sidney, Fisher, Richard J, Hook, Carolyn, Johnson, Neva, Joseph, David, Liew, Kuen H, Morgan, Graeme, O'Brien, Peter, Pendlebury, Sue, Pratt, Gary, Quong, George, Thornton, Deborah, Walker, Quenten, Wallington, Margaret, and Trotter, Grant. Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care. United States: N. p., 1995. Web. doi:10.1016/0360-3016(94)E0261-H.
Barton, Michael, Boyages, John, Crennan, Elizabeth, Davis, Sidney, Fisher, Richard J, Hook, Carolyn, Johnson, Neva, Joseph, David, Liew, Kuen H, Morgan, Graeme, O'Brien, Peter, Pendlebury, Sue, Pratt, Gary, Quong, George, Thornton, Deborah, Walker, Quenten, Wallington, Margaret, & Trotter, Grant. Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care. United States. doi:10.1016/0360-3016(94)E0261-H.
Barton, Michael, Boyages, John, Crennan, Elizabeth, Davis, Sidney, Fisher, Richard J, Hook, Carolyn, Johnson, Neva, Joseph, David, Liew, Kuen H, Morgan, Graeme, O'Brien, Peter, Pendlebury, Sue, Pratt, Gary, Quong, George, Thornton, Deborah, Walker, Quenten, Wallington, Margaret, and Trotter, Grant. 1995. "Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care." United States. doi:10.1016/0360-3016(94)E0261-H. https://www.osti.gov/servlets/purl/10.1016/0360-3016(94)E0261-H.
@misc{etde_20390982,
title = {Radiation therapy for early stage Hodgkin's disease: Australasian patterns of care}
author = {Barton, Michael, Boyages, John, Crennan, Elizabeth, Davis, Sidney, Fisher, Richard J, Hook, Carolyn, Johnson, Neva, Joseph, David, Liew, Kuen H, Morgan, Graeme, O'Brien, Peter, Pendlebury, Sue, Pratt, Gary, Quong, George, Thornton, Deborah, Walker, Quenten, Wallington, Margaret, and Trotter, Grant}
abstractNote = {Purpose: Analysis of treatment outcome for Stage I-IIA supradiaphragmatic Hodgkin's disease treated solely by irradiation in Australia and New Zealand. Methods and Materials: Patients with supradiaphragmatic Hodgkin's disease only who were treated by irradiation alone with curative intent between 1969 to 1988 were retrospectively reviewed. Ten radiation oncology departments in Australia and New Zealand contributed patient data to the study. Patient, tumor, and treatment variables were recorded. Disease-free interval, survival, and complications were analyzed. Results: Eight hundred and twenty patients were reviewed. The median age was 29 years. There were 437 men and 383 women. The distribution of 310 clinically staged patients was 170 stage IA, 5 IB, and 135 IIA. Five hundred and ten patients received laparotomies, and pathologic staging was as follows: IA 214, IB 13, IIA 283. The 10-year acturial disease-free rate was 69% and overall survival rate was 79%. Increasing age, male sex, higher number of involved sites, the use of involved field irradiation, no staging laparotomy, and earlier year of treatment were significantly associated with an increased risk of relapse and lower survival. Actuarial 10-year survival following recurrence was 48%. Acute complications requiring interruption to treatment occurred in 46 patients (6%), but < 1% had their treatment permanently suspended. Actuarial complication rates at 10 years were: cardiac 2%, pulmonary 3% and thyroid 5%. There were 44 second malignancies including 10 non-Hodgkin's lymphomas, 3 leukemias, 7 lung, and 6 breast cancers. Mean delay to the development of a second cancer was 6 years. The 10-year actuarial rate of second malignancy was 5%. Conclusions: The Australasian experience of early stage Hodgkin's disease is consistent with the results in the published literature and confirms that irradiation produces a high cure rate with minimal toxicity.}
doi = {10.1016/0360-3016(94)E0261-H}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {2}
volume = {31}
journal type = {AC}
place = {United States}
year = {1995}
month = {Jan}
}