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Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy

Abstract

Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability. Methods and Materials: Seventeen patients with solitary T2-T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week. Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability. Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients  More>>
Publication Date:
Mar 01, 2003
Product Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 55; Journal Issue: 3; Other Information: PII: S0360301602041585; Copyright (c) 2003 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); PBD: 1 Mar 2003
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLADDER; CARCINOMAS; MOTION; QUALITY ASSURANCE; RADIATION DOSES; RADIOTHERAPY; RECTUM
OSTI ID:
20390714
Country of Origin:
United States
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0360-3016; IOBPD3; TRN: US03R0527030551
Submitting Site:
INIS
Size:
page(s) 835-841
Announcement Date:

Citation Formats

Pos, Floris J, Koedooder, Kees, Hulshof, Maarten C.C.M., Tienhoven, Geertjan van, and Gonzalez Gonzalez, Dionisio. Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy. United States: N. p., 2003. Web. doi:10.1016/S0360-3016(02)04158-5.
Pos, Floris J, Koedooder, Kees, Hulshof, Maarten C.C.M., Tienhoven, Geertjan van, & Gonzalez Gonzalez, Dionisio. Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy. United States. doi:10.1016/S0360-3016(02)04158-5.
Pos, Floris J, Koedooder, Kees, Hulshof, Maarten C.C.M., Tienhoven, Geertjan van, and Gonzalez Gonzalez, Dionisio. 2003. "Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy." United States. doi:10.1016/S0360-3016(02)04158-5. https://www.osti.gov/servlets/purl/10.1016/S0360-3016(02)04158-5.
@misc{etde_20390714,
title = {Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy}
author = {Pos, Floris J, Koedooder, Kees, Hulshof, Maarten C.C.M., Tienhoven, Geertjan van, and Gonzalez Gonzalez, Dionisio}
abstractNote = {Purpose: To assess the spatial variability of a bladder tumor relative to the planning target volume boundaries during radical radiotherapy, and furthermore to develop strategies to reduce spatial variability. Methods and Materials: Seventeen patients with solitary T2-T4N0M0 bladder cancer were treated with a technique delivering 40 Gy/2 Gy in 20 fractions to the whole bladder with a concomitant boost to the bladder tumor of 20 Gy in 1 Gy fractions in an overall time of 4 weeks. CT scans were made weekly, immediately after treatment, and matched with the planning CT scan. Spatial variability of the tumor, as well as bladder volume and rectal diameter, were scored for each patient each week. Results: In 65% of patients, a part of the tumor appeared outside the planning target volume boundaries at least one time during the course of radiotherapy. No consistent relation of this variability with time was found. Bladder volumes and rectal diameters showed marked variability during the course of treatment. A large initial bladder volume and rectal diameter predicted a large volume variation and a large tumor spatial variability. Conclusion: In this study, a margin of 1.5 to 2 cm seemed to be inadequate in 65% of the patients with respect to spatial variability. Bladder volume and rectal diameter were found to be predictive for spatial variability of a bladder tumor during concomitant boost radiotherapy.}
doi = {10.1016/S0360-3016(02)04158-5}
journal = {International Journal of Radiation Oncology, Biology and Physics}
issue = {3}
volume = {55}
journal type = {AC}
place = {United States}
year = {2003}
month = {Mar}
}