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Differential diagnosis of radiation injury

Miscellaneous:

Abstract

A single haematological alteration is not sufficient to diagnose whether it is a radiation-induced change or not. For the differential diagnosis of possibly radiation-induced changes in the peripheral blood and blood-forming organs, information on the radiation exposure in terms of time, quality, quantity and localization, and the clinical symptoms have to be taken into account. Ionizing radiation within the dosage range considered here produces cell division delay, mitotic inhibition, chromosomal damage or interphase cell death; it thereby interferes with the steady-state equilibria in the cell-renewal systems of the organism (Bond et al., 1965; Little, 1968). The cause of haematological changes appearing immediately after a short-term, external whole-body radiation exposure has been described and analysed elsewhere in this Manual. The critical cell component is the 'stem cell compartment' which is highly radiosensitive and suffers damage but, because stem cells cannot be identified morphologically, a direct study of stem cell injury is not possible.
Authors:
Publication Date:
Apr 01, 1971
Product Type:
Miscellaneous
Report Number:
STI/DOC-10/123
Resource Relation:
Other Information: PBD: Apr 1971; Related Information: In: Manual on radiation haematology, Technical reports seriesno. 123, 441 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BLOOD CELLS; BLOOD CHEMISTRY; BLOOD FORMATION; BONE MARROW; BONE MARROW CELLS; DIAGNOSIS; HEMATOLOGY; MORPHOLOGICAL CHANGES; RADIATION DOSES; RADIATION INJURIES
OSTI ID:
20386464
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0302315066392
Submitting Site:
INIS
Size:
page(s) 297-301
Announcement Date:

Miscellaneous:

Citation Formats

Wendt, F. Differential diagnosis of radiation injury. IAEA: N. p., 1971. Web.
Wendt, F. Differential diagnosis of radiation injury. IAEA.
Wendt, F. 1971. "Differential diagnosis of radiation injury." IAEA.
@misc{etde_20386464,
title = {Differential diagnosis of radiation injury}
author = {Wendt, F}
abstractNote = {A single haematological alteration is not sufficient to diagnose whether it is a radiation-induced change or not. For the differential diagnosis of possibly radiation-induced changes in the peripheral blood and blood-forming organs, information on the radiation exposure in terms of time, quality, quantity and localization, and the clinical symptoms have to be taken into account. Ionizing radiation within the dosage range considered here produces cell division delay, mitotic inhibition, chromosomal damage or interphase cell death; it thereby interferes with the steady-state equilibria in the cell-renewal systems of the organism (Bond et al., 1965; Little, 1968). The cause of haematological changes appearing immediately after a short-term, external whole-body radiation exposure has been described and analysed elsewhere in this Manual. The critical cell component is the 'stem cell compartment' which is highly radiosensitive and suffers damage but, because stem cells cannot be identified morphologically, a direct study of stem cell injury is not possible.}
place = {IAEA}
year = {1971}
month = {Apr}
}