Abstract
Tumor cell components obtained at 5 min, 1 hr and 3 hr after {sup 18}F-FDG injections were analyzed by radio-thin-layer chromatography (TLC). Major metabolites were {sup 18}F-FDG-phosphate and {sup 18}F-FDM-phosphate. {sup 18}F-FDM and three unidentified compounds were found as minor metabolites. Time course of the composition of metabolites are as follows; {sup 18}F-FDG-phosphate was 88% at 5 mm after injection, but decreased to 53% at 3 hr after. {sup 18}F-FDM-phosphate was increased to 38% at 3 hr after injection. In conclusion, {sup 18}F-FDG is promptly phosphorylated after transportation into cell, and then exists as FDG-phosphate or {sup 18}F-FDM-phosphate. These results support known FDG distribution and metabolism, and it is possible that we use the information accumulated until now employing FDG manufactured by commercial supply system. (author)
Shimmura, Toshiyuki;
Ino, Sento;
Kurami, Miki;
[1]
Nemoto, Masahiro
[2]
- Nihon Medi-physics Co., Ltd., Sodegaura, Chiba (Japan). Research Centre
- Japanese Red Cross Hokkaido Coll. of Nursing, Kitami (Japan)
Citation Formats
Shimmura, Toshiyuki, Ino, Sento, Kurami, Miki, and Nemoto, Masahiro.
Metabolism of {sup 18}F-FDG (2-fluoro-2-deoxy-D-glucose) in tumor cells.
Japan: N. p.,
2003.
Web.
Shimmura, Toshiyuki, Ino, Sento, Kurami, Miki, & Nemoto, Masahiro.
Metabolism of {sup 18}F-FDG (2-fluoro-2-deoxy-D-glucose) in tumor cells.
Japan.
Shimmura, Toshiyuki, Ino, Sento, Kurami, Miki, and Nemoto, Masahiro.
2003.
"Metabolism of {sup 18}F-FDG (2-fluoro-2-deoxy-D-glucose) in tumor cells."
Japan.
@misc{etde_20354682,
title = {Metabolism of {sup 18}F-FDG (2-fluoro-2-deoxy-D-glucose) in tumor cells}
author = {Shimmura, Toshiyuki, Ino, Sento, Kurami, Miki, and Nemoto, Masahiro}
abstractNote = {Tumor cell components obtained at 5 min, 1 hr and 3 hr after {sup 18}F-FDG injections were analyzed by radio-thin-layer chromatography (TLC). Major metabolites were {sup 18}F-FDG-phosphate and {sup 18}F-FDM-phosphate. {sup 18}F-FDM and three unidentified compounds were found as minor metabolites. Time course of the composition of metabolites are as follows; {sup 18}F-FDG-phosphate was 88% at 5 mm after injection, but decreased to 53% at 3 hr after. {sup 18}F-FDM-phosphate was increased to 38% at 3 hr after injection. In conclusion, {sup 18}F-FDG is promptly phosphorylated after transportation into cell, and then exists as FDG-phosphate or {sup 18}F-FDM-phosphate. These results support known FDG distribution and metabolism, and it is possible that we use the information accumulated until now employing FDG manufactured by commercial supply system. (author)}
journal = []
issue = {1}
volume = {40}
journal type = {AC}
place = {Japan}
year = {2003}
month = {Feb}
}
title = {Metabolism of {sup 18}F-FDG (2-fluoro-2-deoxy-D-glucose) in tumor cells}
author = {Shimmura, Toshiyuki, Ino, Sento, Kurami, Miki, and Nemoto, Masahiro}
abstractNote = {Tumor cell components obtained at 5 min, 1 hr and 3 hr after {sup 18}F-FDG injections were analyzed by radio-thin-layer chromatography (TLC). Major metabolites were {sup 18}F-FDG-phosphate and {sup 18}F-FDM-phosphate. {sup 18}F-FDM and three unidentified compounds were found as minor metabolites. Time course of the composition of metabolites are as follows; {sup 18}F-FDG-phosphate was 88% at 5 mm after injection, but decreased to 53% at 3 hr after. {sup 18}F-FDM-phosphate was increased to 38% at 3 hr after injection. In conclusion, {sup 18}F-FDG is promptly phosphorylated after transportation into cell, and then exists as FDG-phosphate or {sup 18}F-FDM-phosphate. These results support known FDG distribution and metabolism, and it is possible that we use the information accumulated until now employing FDG manufactured by commercial supply system. (author)}
journal = []
issue = {1}
volume = {40}
journal type = {AC}
place = {Japan}
year = {2003}
month = {Feb}
}