Abstract
Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ({sup 99m}Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD. (orig.)
Szobot, Claudia M;
Ketzer, Carla;
Kapczinski, Flavio;
[1]
Cunha, Renato D;
[2]
Parente, Maria A;
[3]
Langleben, Daniel D;
[4]
Acton, Paul D;
[5]
Rohde, Luis A.P.;
[1]
Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)]
- Department of Psychiatry, Federal University of Rio Grande do Sul (Brazil)
- Service of Nuclear Medicine, Hospital de Clinicas de Porto Alegre (Brazil)
- Department of Psychology, Federal University of Rio Grande do Sul (Brazil)
- Department of Psychiatry, University of Pennsylvania (United States)
- Department of Radiology, University of Pennsylvania (United States)
Citation Formats
Szobot, Claudia M, Ketzer, Carla, Kapczinski, Flavio, Cunha, Renato D, Parente, Maria A, Langleben, Daniel D, Acton, Paul D, Rohde, Luis A.P., and Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)].
The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder.
Germany: N. p.,
2003.
Web.
doi:10.1007/s00259-002-1082-0.
Szobot, Claudia M, Ketzer, Carla, Kapczinski, Flavio, Cunha, Renato D, Parente, Maria A, Langleben, Daniel D, Acton, Paul D, Rohde, Luis A.P., & Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)].
The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder.
Germany.
https://doi.org/10.1007/s00259-002-1082-0
Szobot, Claudia M, Ketzer, Carla, Kapczinski, Flavio, Cunha, Renato D, Parente, Maria A, Langleben, Daniel D, Acton, Paul D, Rohde, Luis A.P., and Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)].
2003.
"The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder."
Germany.
https://doi.org/10.1007/s00259-002-1082-0.
@misc{etde_20351681,
title = {The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder}
author = {Szobot, Claudia M, Ketzer, Carla, Kapczinski, Flavio, Cunha, Renato D, Parente, Maria A, Langleben, Daniel D, Acton, Paul D, Rohde, Luis A.P., and Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)]}
abstractNote = {Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ({sup 99m}Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD. (orig.)}
doi = {10.1007/s00259-002-1082-0}
journal = []
issue = {3}
volume = {30}
journal type = {AC}
place = {Germany}
year = {2003}
month = {Mar}
}
title = {The acute effect of methylphenidate on cerebral blood flow in boys with attention-deficit/hyperactivity disorder}
author = {Szobot, Claudia M, Ketzer, Carla, Kapczinski, Flavio, Cunha, Renato D, Parente, Maria A, Langleben, Daniel D, Acton, Paul D, Rohde, Luis A.P., and Servico de Psiquiatria da Infancia e Adolescencia, Hospital de Clinicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, CEP 90035-003, RS Porto Alegre (Brazil)]}
abstractNote = {Methylphenidate (MPH) is the most commonly prescribed treatment for attention-deficit/hyperactivity disorder (ADHD). The therapeutic mechanisms of MPH are not, however, fully understood. We studied the effects of MPH on brain activity in male children and adolescents with ADHD, using the blood flow radiotracer technetium-99m ethyl cysteinate dimer ({sup 99m}Tc-ECD) and single-photon emission tomography (SPET). The study was randomized, double blind, and placebo controlled (MPH group, n=19; placebo group, n=17), Radiotracer was administered during the performance of the Continuous Performance Test and before and after 4 days of MPH treatment. Statistical parametric mapping (SPM99) analysis showed a significant reduction in regional cerebral blood flow in the left parietal region in the MPH group compared with the placebo group (P<0.05, corrected for multiple comparisons). Our findings suggest that the posterior attentional system, which includes the parietal cortex, may have a role in the mediation of the therapeutic effects of MPH in ADHD. (orig.)}
doi = {10.1007/s00259-002-1082-0}
journal = []
issue = {3}
volume = {30}
journal type = {AC}
place = {Germany}
year = {2003}
month = {Mar}
}