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Do children with aggressive behavior have temporal lobe changes?

Journal Article:

Abstract

Aggressive behavior and mood disorders may afflict children. One problem is the lack of objective data to arrive at a specific clinical diagnosis. Abnormalities in neurotransmitters such as serotonin, dopamine, acetylcholine and gamma-aminobutyric acid have been reported to play an important role in the onset of these disorders. We studied 8 patients, 3 girls and 5 boys, ages ranging from 6 to 12, referred to us with the diagnosis of ADHD or autism and reported as having temper problems by their families. These patients were injected with a dose of Tc-99m HMPAO calculated according to patient age and weight and were imaged 1 hour later using a Picker camera with Fan Beam collimators. We analyzed the brain SPECT using 3D as well as the traditional transverse, coronal and sagittal images. With the help of surface rendered 3D images with a cut off of 88% (high) and 60-65% (lower value depending on the patient RCBF value), we observed increased perfusion or activation of either or both right and left temporal lobes in all 8 of the patients. This pattern was not seen in children whose parents did not report temper problems. Increase in perfusion to the temporal lobes may indicate an  More>>
Authors:
Thomas, C T; Mishkin, F; Goldberg, M [1] 
  1. Department of Nuclear Medicine, Harbor-UCLA Medical Center, Torrance, CA (United States)
Publication Date:
Sep 01, 2002
Product Type:
Journal Article
Resource Relation:
Journal Name: World Journal of Nuclear Medicine; Journal Volume: 1; Journal Issue: suppl.2; Conference: 8. Congress of the World Federation of Nuclear Medicine and Biology, Santiago (Chile), 29 Sep - 2 Oct 2002; Other Information: PBD: Sep 2002
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACETYLCHOLINE; BEHAVIOR; BIOELECTRICITY; BRAIN; BUTYRIC ACID; CHILDREN; DOPAMINE; SEROTONIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
OSTI ID:
20347643
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1450-1147; TRN: XA03W0330032147
Submitting Site:
INIS
Size:
page(s) 148
Announcement Date:
Jun 07, 2003

Journal Article:

Citation Formats

Thomas, C T, Mishkin, F, and Goldberg, M. Do children with aggressive behavior have temporal lobe changes?. IAEA: N. p., 2002. Web.
Thomas, C T, Mishkin, F, & Goldberg, M. Do children with aggressive behavior have temporal lobe changes?. IAEA.
Thomas, C T, Mishkin, F, and Goldberg, M. 2002. "Do children with aggressive behavior have temporal lobe changes?" IAEA.
@misc{etde_20347643,
title = {Do children with aggressive behavior have temporal lobe changes?}
author = {Thomas, C T, Mishkin, F, and Goldberg, M}
abstractNote = {Aggressive behavior and mood disorders may afflict children. One problem is the lack of objective data to arrive at a specific clinical diagnosis. Abnormalities in neurotransmitters such as serotonin, dopamine, acetylcholine and gamma-aminobutyric acid have been reported to play an important role in the onset of these disorders. We studied 8 patients, 3 girls and 5 boys, ages ranging from 6 to 12, referred to us with the diagnosis of ADHD or autism and reported as having temper problems by their families. These patients were injected with a dose of Tc-99m HMPAO calculated according to patient age and weight and were imaged 1 hour later using a Picker camera with Fan Beam collimators. We analyzed the brain SPECT using 3D as well as the traditional transverse, coronal and sagittal images. With the help of surface rendered 3D images with a cut off of 88% (high) and 60-65% (lower value depending on the patient RCBF value), we observed increased perfusion or activation of either or both right and left temporal lobes in all 8 of the patients. This pattern was not seen in children whose parents did not report temper problems. Increase in perfusion to the temporal lobes may indicate an association with oppositional or aggressive behavior that may be amenable to treatment. Brain SPECT may be useful not only in early diagnosis, but also in guiding appropriate therapy.}
journal = {World Journal of Nuclear Medicine}
issue = {suppl.2}
volume = {1}
journal type = {AC}
place = {IAEA}
year = {2002}
month = {Sep}
}